| Project/Area Number |
04670672
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University |
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Principal Investigator |
MATSUNAGA Naofumi Nagasaki University Department of Radiology, Associate Professor, 医学部, 助教授 (40157334)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Yoji Nagasaki University Department of Radiology, 医学部, 医員
SAKAMOTO Ichiro Nagasaki University Department of Radiology, Instructor, 医学部, 助手 (00225806)
HAYASHI Kuniaki Nagasaki University Department of Radiology, Professor, 医学部, 教授 (80039536)
木下 博史 長崎大学, 医学部, 助教授 (10039878)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | MRI / Myocardial infarction / Contrast media / Gd-DTPA / Spin-echo image |
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| Research Abstract |
PURPOSE : We assessed the effectiveness of gadopentetate dimeglumine injection in enhancing signal-intensity differences between normal and infarcted myocardium on ECG-gated spin-echo T1-weighted images. MATERIALS AND METHODS : The 84 MR examinations of 66 patients 14-350 days after acute myocardial infarction were obtained before and after administration of 0.1mmol/kg of Gd-DTPA (gadopentetate dimeglumine). Image acquisitions were repeated every 5 min with 3 minutes gap for up to 26 min in three sequential scans in 58 patients, and for up to 42 min in five sequential scans in ten patients. Time-dependent changes in signal intensity ratio between infarcted and normal myocardium (infarct/normal ratio) and serial changes of infarct/normal ratio in different stages were measured. RESULTS : Contrast enhancement of the infarcted myocardium was observed in 66 of 84 patients (78.6%). Infarct/normal ratio was increased at the initial acquisition during 5-10 minutes, reached the plateau at 13-18 minutes of acquisition, 21-26 minutes, and 29-34 minutes, and the augmented ratios gradually declined at 37-42 minutes. Contrast enhancement of the infarcted myocardium was observed in 9 of 10 (90.0%) imaged at 1-3 weeks after acute myocardial infarction, in 16 of 19 examinations (84.2%) at 4-6 weeks, in 24 of 29 (82.8%) at 7-9 weeks, in 16 of 21 (76.2%) at 10-32 weeks, and in none of 5 (0%) at 33-50 weeks. CONCLUSION : These results suggest that Gd-DTPA can improve MR visualization and detection of myocardial infarction, and facilitates the process of the repair of the myocardial infarction.
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