| Project/Area Number |
04670705
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Oita Medical University |
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Principal Investigator |
NAGAYAMA Haruo Oita Medical University, Department of Neuropsychiatry, Associate Professor, 医学部, 助教授 (70100899)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | SEASONAL AFFECTIVE DISORDER / PHOTOTHERAPY / BIOLOGICAL RHYTHMS |
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| Research Abstract |
(1)Clinical Study : Following a 1-week drug-free period, a three step light therapy was applied to six inpatients and one outpatient with seasonal affective disorder for a total of 30 days which involved exposure to either bright-dim-bright light or dim-bright-dim light. The irradiation occurred between 6 : 00 AM and 8 : 00 AM.The clinical severity of depression was evaluated using the Hamilton Rating Scale for Depression, SAD version (HAMSAD). Prior to treatment, the patients completed questionnaires concerning their expectations for this therapy, and the Maudsley Personality Inventory was administered.
Bright light was associated with significant improvement in HAMSAD scores, whereas dim light had no effect. The degree of patient's expectation for phototherapy before treatment was not different between the effective group and the ineffective group in bright light therapy. The Maudsley Personality Inventory showed no differences between these two groups in any items. The results suggest that the clinical effects of phototherapy may be based on a specific effect of light.
(2)Animal Study : Lithium and imipramine were chronically injected into rats, and rhythms of temperature and activity were measured. Lithium but not imipramine lengthened the period of biological rhythms. Both drugs changed the acrophase of rhythms.
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