| Project/Area Number |
04670729
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | MIE UNIVERSITY |
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Principal Investigator |
KITAGAWA Tatsushi MIE UNIVERSITY.UNIVERSITY HOSPITAL.ASSISTANT, 医学部・附属病院, 助手 (20169858)
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| Co-Investigator(Kenkyū-buntansha) |
AZUMA Takaaki MIE UNIVERSITY.FACULTY OF MEDICINE.ASSISTANT, 医学部・附属病院, 助手 (50242938)
寺西 正 三重大学, 医学部, 助手 (60172102)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Hepatic Ischemia / Parenteral Nutrition / Lipid Emulsion / Fatty Acid / Beta-Oxidation / ブドウ糖 / 磁気共鳴スペクトロスコピー |
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| Research Abstract |
Changes of hepatic energy balance caused by ischemia was determined by measuring beta-ATP/Pi (inorganic phosphrus) using magnetic resonance spectroscopy. Ischemia induced a significant reduction of beta-ATP/Pi. The reduced ratio of beta-ATP/Pi returned to the 85% of the basal value 5 hours after restoration of the hepatic blood-flow. Hepatic ischemia induced also the arterial ketone body ratio (acetoacetate/beta-hydroxybutylate) which is representative of hepatic redox state. Influences of infusions of glucose and/or lipid emulsion on hepatic energy balance after ischmemia were investigated. The results suggested that, after cold ischemia, an immediate supply of a large (0.75g/h/rat) amount of glucose inhibited the recovery of energy balance of the liver, while a supply of limited amounts of glucose (0.37g/h/rat) after some delay did not appear to be detrimental to the liver. Concerning fatty acids oxidation, it was demonstrated that the ischemic liver restores the functions for beta-oxidation after the induction of hepatic blood-flow. The timing of this restoration of function is identical to the timing of the return of the arterial ketone body ratio to the normal range (higher than 0.65). In conclusion, after liver surgery complicated with hepatic ischemia, parenteral use of limited amounts of glucose as well as lipid emulsion appear to enhance recovery of hepatic energy balance a far as these nutritional substates are administered are administered when the arterial ketone body ratio returns to the levil of higher than 0.65.
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