| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1992: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Research Abstract |
Diabetic prone (DP)-BB tats rejected MHC-compatible and mH-incompatible DR pancreases within a MST of 24(〕SY.+-.〔)4.2 days. DR-BB recipients when treated with anti ICAM-1/LFA-A mABs. The recurrence of IDDM was consistently observed in DP-BB recipients transplanted with WFu pancreases. Diabetic DP rats had a feature of lymphocytopenia and T cell hyporesponsiveness against mitogens or alloantigens. In peripheral lymphoid tissues, DP rats also had no RT6^+T cells , which regulate immune responses and correlate with T cell dysfunction an doccurrence of IDDM.This type of T cell dysfunction was mot observed in WFu or DR rats, In the case of IDDM recurrence of WFu to DP combination, the DP recipients still had a feature of T lymphocyopenia and T cell dysfunction without the appearance of RT6^+T cells. The DP recipients, whichrejected DR pancreatic graft, also showed T dell dysfunction with T hymphocytopenia, In this mechanism of rejection, humaral immune responses were enhanced tather than cellular rsponses. As an interesting result of fact, however, DP rats which accepted DR pancreatic grafts with anti-adhesion molecule mAbs demonstrated the increased number of T cells, the restoration of T cell function and the appearanceof RT6^+T cells, which sechanisms are unclear, may be responsible for the restoration of T cell dysfunction and the protection of IDDM recurrence.
Rat pancreas transplantation
IDDM
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