| Project/Area Number |
04670763
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tokyo |
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Principal Investigator |
SANJO Kensho University of Tokyo, Associate Prof, 医学部(病), 助教授 (90114503)
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| Co-Investigator(Kenkyū-buntansha) |
HARIHARA Yasushi Okinaka Memorial Research Institute, research fellow, 中央成人病研究所, 研究員 (10189714)
SAKAMOTO Hirohiko University of Tokyo, clinical fellow, 医学部(病), 医員 (40196100)
橋本 雅司 東京大学, 医学部(病), 助手 (70221497)
國土 典宏 東京大学, 医学部(病), 助手 (00205361)
日下 浩二 東京大学, 医学部(病), 医員
三木 健司 東京大学, 医学部(病), 医員
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Hepatic xenotransplantation, / Cardiac xenotransplantation / Concordant xenotransplatation / 肝移植 / 異種移植 |
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| Research Abstract |
Although orthotopic liver transplantation has been accepted as the treatment for end-stage hepatic diseases, the availability of organ donors remains a serious constraint to its widespread use. Hepatic xenotransplantation is one of the resolutions for this organ shortage. Recently two cases of concordant balloon-to-human liver xenotransplantation and a case of discordant pig-to-human liver xenotransplantation were performed in U.S.A., but they did not produce good results. In this regard experimental research on hepatic xenotransplantation is needed for the successful clinical application of this procedure.
Although concordant hamster-to-rat hepatic xenotransplantation is a suitable model for this research, the difficulty in making model is an obstacle to the research in this field. We introduced three-cuff method, in which suprahepatic vena cava anastomosis is made using a specially designed cuff, and confirmed its usefulness in achieving the good survival rates.
Three-cuff method is a useful technique in making hamster-to-rat orthotopic hepatic xenotransplantation model. We hope experimantal research on hepatic xenotransplantation can be widely performed using this technique.
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