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A new approach to arterial and portal chemoembolization therapy for unresectable hepatocellular carcinoma

Research Project

Project/Area Number 04670791
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKumamoto university medical school

Principal Investigator

KATAFUCHI Shigeru  Kumamoto university medical school, Department of Surgery II, reserch associate, 医学部, 助手 (50233747)

Co-Investigator(Kenkyū-buntansha) IKEI Satoshi  Kumamoto university medical school, Department of Surgery II, assistant professo, 医学部, 講師 (90136705)
OGAWA Michio  Kumamoto university medical school, Department of Surgery II, professor, 医学部, 教授 (30028691)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
KeywordsPercutaneous transhepatic portal chemoembolization (PTPCE) / Transcatheter arterial chemoembolization (TACE) / Cisplatin suspended in lipiodol(CSL)-fibrin adhesive mixture / Hepatocellular carcinoma (HCC) / Chemoembolization / 原発性肝細胞癌 / 肝動脈塞栓化学療法
Research Abstract

We developed cisplatin suspended in lipiodol (CSL)-fibrin adhesive mixture as a new embolic material in arterial and portal chemoembolization therapy for unresectable hepatocellular carcinoma (HCC).
Experimental study
A rat HCC model was made by intraportal inoculation of AH136B rat ascites hepatoma cell. Percutaneous transhepatic portal chemoembolization (PTPCE) performed 4 days after the cell inoculation, resulted in prolonging the survival time, inhibiting the tumor growth, and suppressing the intrahepatic metastasis in comparison with control animals.
Clinical data
We treated twelve patients with HCC by PTPCE in combination with transcatheter arterial chemoembolization (TACE). PTPCE could be performed safely in all cases. According to response criteria, response rate was 66.7%. The cumulative survival rate at 2 years was 80.0%. In resectable cases after TACE/PTPCE, histological examination revealed necrotic changes of the main tumor and the portal embolus. There were no lethal side effects and complications through the study.
Conclusion
PTPCE in combination with TACE has exellent therapeutic effects not only for main tumor but also for portal or capsular invasion. PTPCE may become a useful tool in the treatment of unresectable HCC.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] TORU BEPPU: "A new chemoembolization therapy for unresectable hepatocellular carcinoma using Aclarubicin microspheres in combination with Cisplatin suspended in lipiodol." REG.CANCER TREAT.1-2. 33-35 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] SATOSHI IKEI: "Changes in IL-6,IL-8,C-reactive protein and Pancreatic secretory trypsin inhibitor after Transcatheter arterial chemo-embolization therapy for hepatocellular carcinoma." CYTOKINE. 4. 581-584 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Beppu, C.Ohara, Y.Yamaguchi, T.Yamanaka, S.Katafuchi, S.Ikei, S.Kudo, Y.Masuda, S.fukushima, M.Nakano, M.Ogawa: "A new chemoembolization therapy for unresectable hepatocellular carcinoma using Aclarubicin microspheres in combination with Cisplatin suspended in lipiodol." Reg.Cance Treat. 1-2. 33-35 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Satoshi Ikei, Michio Ogawa, Toru Beppu, Chitoshi Ohara, Kiyoshi Sakamoto, Hirofumi Sameshima, Hirohumi Arakawa, Yasuo Yamaguchi, Tsuyoshi Yamanaka, Shunsuke Kudou: "Changes in Interleukin 6, Interleukin 8, C-reactive Protein and Pancreatic Secretory Trypsin Inhibitor(PSTI) after Transcatheter Arterial Chemoembolization Therapy (TACE)." CYTOKINE. 4. 581-584 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Satoshi Ikei: "Changes in Interleukin 6,Interleukin 8,C-reactive protein and Panceatic Secretory Trypsin Inhibitor after Transcatheter Arterial Chemoembolization" CYTOKINE. 4. 581-584 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Toru Beppu: "A new chemoembolization therapy for unresectable hepatocellular carcinoma using Aclarubium microspheres in combination with cispktin suspended in lipiodol" Reg.Cancer Treat.1-2. 33-35 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Satoshi Ikei: "Changes in IL-6,IL-8,c-reactive protein and pancreatic secretory trypsin inhibitor after transcatheter arterial chemoembelization for hepato cellvler carcinoma" CYTOKINE. 4. 581-584 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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