Experiments in the effect of ischemic-reperfusion injury and regeneration of the mucosa in small bowel transplantation
| Project/Area Number |
04670806
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Jikei Medical Univ. |
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Principal Investigator |
KASIWAZAKI Osamu Jikei Med.Univ.Prof, 医学部, 教授 (20056518)
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| Co-Investigator(Kenkyū-buntansha) |
TABEI Isao Jikei Med.Univ.Resident, 第二外科教室, 助手
TABATA Yasuhiro Jikei Med.Univ.Resident, 第二外科教室, 助手 (20256415)
TSUDA Naoya Jikei Med.Univ.Resident, 第二外科教室, 助手 (50246419)
KOBO Hirotaka Jikei Med.Univ.Ch.Resi, 第二外科教室, 講師 (70119791)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | intestinal mucosa / free radical / ischemia / purine metabolism / xanthine oxidase / キサンチンオキシターゼ / 小腸移植 / 粘膜障害 |
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| Research Abstract |
By observing the purine metabolism of the gastric and small bowel mucosa, the characteristics, pathology, and viability of the mucosa was determined. Measurements of purine metabolites showed no respectable differences between the gastric and ileal mucosa. Whereas the jejunal mucosa showed a respectable difference compared to the other tissues. Because the purine metabolites were higher in jejunal tissue, this may become a risk to the mucosa from being damaged by free radicals caused by Xanthine oxidase, the key enzyme in the purine metabolism. In conclusion the jejumun seems to be vulnerable to ischemia-reperfusion injury compared to other tissues. Further research concerning transplantation mucosal tissue damage will be carried out by my co-leagues for I am retiring this year.
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Report
(3 results)
Research Products
(1 results)
