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BILE ACID LOAD ON THE OCCURRENCE OF CHOLANGIOCARCINOMA INDUCED BY DIISOPROPANOLNITROSAMINE

Research Project

Project/Area Number 04670810
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKANAZAWA MEDICAL UNIVERSITY

Principal Investigator

KINAMI Yoshio  KANAZAWA MEDICAL UNIVERSITY・MEDICAL RESEARCH INSTITUTE・PROFESSOE, 総合医学研究所, 教授 (00019928)

Co-Investigator(Kenkyū-buntansha) SETO Keitaro  KANAZAWA MEDICAL UNIVERSITY・SCHOOL OF MEDICINE・ASSISTANT, 医学部, 助手 (40216544)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
KeywordsCholangiocarcinoma / Bile Acid Load / Deoxycholic Acid / Diisopropanolnitrosamine / deoxycholic acid.
Research Abstract

This study was performed to clarify the promoting effects of primary or secondary bile acid load on the occurrence of cholangiocarcinoma, using Syrian golden hamsters. These hamsters received subcutaneously diisopropanolnitrosamine (DIPN) once weekly for 10 weeks, and simultaneously were given a standard pellet diet (control group) containing taurocholic acid (TCA group) or deoxycholic acid (DCA group). The rates of cholangiocarcinoma at 20 weeks were 23% in the control group, 60% in the TCA group and 59% in the DCA group. There were significant differences between the control and the TCA or DCA groups (p<0.05). The rates of proliferation of bile ductules or hyperplasia of the bile duct epithelium and the bromodeoxyuridine labeling indices of bile duct epithelial cells were high in both groups treated with bile acids, compared with those in the control group. Regarding the composition of bile acids in the intraductal bile, the TCA and DCA groups revealed a decrease in primary bile acids and an increase in DCA.These results suggest that both TCA and DCA given orally promote the occurrence of DIPN-induced cholangiocarcinoma.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] 木南 義男: "胆管細胞癌の発生増殖と胆管上皮における細胞学的解析-第二報、Diisopropanolnitrosamine誘発細胆管上皮細胞の核DNA量に及ぼす胆汁酸負荷の影響" 金沢医科大学総合医学研究所年報. 5. 204-212 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 木南 義男: "胆管細胞癌の発生増殖と胆管上皮における細胞学的解析-第一報,誘発胆管細胞癌モデルの作成と病理学的変化の検索" 金沢医科大学総合医学研究所年報. 4. 116-121 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshio Kinami: "Promoting effects of bile acid load on the occurrence of cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters." Oncology. 50. 46-51 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 木南 義男: "Diisopropanolnitrosamine誘発胆管細胞癌発生増殖におよぼす胆汁酸負荷の影響" 金沢医科大学総合医学研究所年報. 2. 159-164 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshio Kinami: "The effect of incomplete bile duct obstruction on diisopropanolnitrosamine-induced cholangiocarcinoma" HPB Surgery. 3. 117-127 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 瀬戸 啓太郎: "Diisopropanolnitrosamine誘発胆管細胞癌発生増殖におよぼす胆管閉塞の影響" 消化器癌の発生と進展. 5. 163-167 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kinami Y,et al: "The occurrence of cholangiocarcinoma and cytologic analysis of the bile duct epithelium-the influence of bile acid load on nuclear DNA content of bile ductule cells induced by diisoprapanol-nitrosamine. (in Japanese)" Ann.Rep.Med.Res.Inst.Kanazawa Med.University. 5. 204-212 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kinami Y,et al: "The occurrence of cholangiocarcinoma and cytologic analysis of the bile duct epithelium-a model of cholangiocarcinoma and pathological changes. (in Japanese)" Ann.Rep.Med.Res.Inst.Kanazawa Med.University. 4. 116-121 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kinami Y,et al: "Promoting effects of bile acid load on the occurrence of cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters." Oncology. 50. 46-51 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kinami Y,et al: "The influence of bile acid load on the occurrence of cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters. (in Japanese)" Ann.Rep.Med.Res.Inst.Kanazawa Med.University. 2. 159-164 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kinami Y,et al: "The effect of incomplete bile duct obstruction on diisopropanolnitrosamine -induced cholangiocarcinoma." HBS Surgery. 3. 117-127 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Seto K,et al: "The influence of incomplete bile duct obstruction on the occurrence of cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters. (in Japanese)" J.Japanese Res.Soc.Gastroent.Carcinogenesis. 5. 163-167 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 木南,義男: "胆管細胞癌の発生増殖と胆管上皮における細胞学的解析-第二報、Diisopropanolnitrosamine誘発細胆管上皮細胞の核DNA量に及ぼす胆汁酸負荷の影響" 金沢医科大学総合医学研究所年報. 5. 204-212 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 木南,義男: "胆管細胞癌の発生増殖と胆管上皮における細胞学的解析-第一報、誘発胆管細胞癌モデルの作成と病理学的変化の検索" 金沢医科大学総合医学研究所年報. 4. 116-121 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshio Kinami: "Promoting effects of bile acid load on the occurrence of cholangiocarcinoma induced by diisopropanolnitrosamine in hamsteres." Oncology. 50. 46-51 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 木南,義男: "Diisopropanolnitrosamine誘発胆管細胞癌発生増殖におよぼす胆汁酸負荷の影響" 金沢医科大学総合医学研究所年報. 2. 159-164 (1992)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshio Kinami: "The effect of incomplete bile obstruction on diisopropanolnitrosamineinduced cholangiocarcinoma" HPB Surgery. 3. 117-127 (1991)

    • Related Report
      1994 Annual Research Report
  • [Publications] 瀬戸啓太郎: "Diisopropanolnitrosamine誘発胆管細胞癌発生増殖におよぼす胆管閉塞の影響" 消化器癌の発生と進展. 5. 163-167 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshio Kinami: "Promoting effects of bile acid load on the occurrence of cho-langiocarcinoma induced by diisopropanolnitrosamine in hamsters." Oncology. 50. 46-51 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 木南,義男: "Diisopropanolnitrosamine誘発胆管細胞癌発生増殖におよぼす胆汁酸負荷の影響" 金沢医科大学総合医学研究所年報. 2. 159-164 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshio Kinami: "The effect of incomplete bile duct obstruction on diisopropanol-nitrosamine-induced cholangiocarcinoma" HPB Surgery. 3. 117-127 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshio Kinami: "Influence of incomplete bile duct obstruction on the occurrence of cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters" Oncology. 47. 170-176 (1990)

    • Related Report
      1993 Annual Research Report
  • [Publications] 木南,義男: "不完全胆管閉塞のdiisopropanolnitrosamine誘発胆管細胞癌発生増殖におよぼす影響" 金沢医科大学総合医学研究所年報. 1. 114-117 (1990)

    • Related Report
      1993 Annual Research Report
  • [Publications] 瀬戸,啓太郎: "Diisopropanolnitrosamine誘発胆管細胞癌発生増殖におよぼす胆管閉塞の影響" 消化器癌の発生と進展. 5. 163-167 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshio Kinami: "Promoting effects of bile acid load on the occurrence of cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters." Oncology. 50. 46-51 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 木南 義男: "Diisopropanolnitrosamine誘発胆管細胞癌発生増殖におよぼす胆汁酸負荷の影響" 金沢医科大学総合医学研究所年報. 2. 159-164 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshio Kinami: "The effect of incomplete bile duct obstruction on diisopropanolnitrosamine-induced cholangiocarcinoma." HPB Surgery. 3. 117-127 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshio Kinami: "Influence of incomplete bile duct obstruction on the occurrence of cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters." Oncology. 47. 170-176 (1990)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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