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Prognssis and distant metestasio of gaotric cancer assessed by fion aytometric analysis of DNA content and tumor infiltrating lymphoeytes

Research Project

Project/Area Number 04670812
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKinki University School of Medicine

Principal Investigator

SHINDO Katsuhisha (1994)  Kinki University of Medicine Professor, 医学部, 教授 (80112043)

黒岡 一仁 (1992-1993)  近畿大学, 医学部, 講師 (40195574)

Co-Investigator(Kenkyū-buntansha) FUJI Yohsinori  Kinki University of Medicine assistant, 医学部, 助手 (80228965)
MORIKAWA Eiji  Kinki University of Medicine assistant Professor, 医学部, 講師 (30210149)
進藤 勝久  近畿大学, 医学部, 助教授 (80112043)
松田 泰次  近畿大学, 医学部, 講師 (10122110)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
KeywordsDNA ploidy pattern / lymphocyte sibsets / gastric cancer / tumor intiltrating lymphocyte / surgical stage / リンパ球サブセット / DNA index / PCNA標識率 / TI / TILサブセット
Research Abstract

we analyzed the lymphocyte subsets in the peripheral blood lymphocytes, lymphocytes in regional nodes and tumor infiltrating lymphocytes in gastric cencer, and tried to eveluate the systemic and local immunity of the host. How the lymphocyte subsets were involved in the tumor malignancy such as DNA ploidy pattern and histological stages, and affected the immunity changes was also examined. The CD4/8 ratio in tumor infiltrating lymphocyted tended to decrease with the progress of cancer-stage. From the view point of the DNA ploidy pattern, the CD4/8 ratio in tumor infiltrating lymphocytes decreased with the progress of the stage in DNA diploidy, but did not show any difference among the stages in DNA aneuploidy. Especially, the CD4/8 ratio in stage IV of DNA aneuploidy was significantly higher than that of DNA diploidy (p<0.05). From the point of the histology, the proportion of cytotoxic T cells in the suppressor T cell+cytotoxic T cells was significantly higher in well differentiated adenocarcinoma than in other histological cancers (p<0.005). These findings indicate an increase in the relative amount of cytotoxic T cells and high tumor immunity in highly differentiated cancers.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 今西幸雄: "Flow cytometryによるDNA ploidy patternとDNA indexからみた胃癌遠隔転移様式の検討" 日本消化器外科学会雑誌. 26. 2395-2400 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 今西幸雄: "Flow cytometryによる核DNA量解析およびPCNA labeling indexからみた胃癌遠隔転移様式の検討" 近畿大学医学雑誌. 18. 521-532 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 佐藤卓: "胃癌のDNA ploidy patternと腫瘍浸潤リンパ球のSubpopulationからみた局所免疫反応" 日本消化器外科学会雑誌. 27. 1132 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 佐藤卓: "Flow cytometryによる胃癌悪性度とリンパ球サブセット解析からみた宿主免疫反応" 近畿大学医学雑誌. 20. (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yukio Imanishi: "Study of DNA ploidy Pattern and DNA Index Using Flow Cytometry in Distant Metastasis of Gastric Cancer" The Japanese Journal of Gastroenterelogical Songery. 26. 2395-2400 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yukio Imanishi: "Distant nestastasis of gastric cancer assessed by flow oztonetric analysis of DNA content and PCNA labeling index" Med.J.Kinki Univ. 18. 521-532 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suguru, Sato: "The locoregional immune response from a view of tumor-infiltrating-lymhocyte sabpopulations and DNA ploidy pattern of geotric cancers." The Japanese Journal of Grotroenterd ogical sunzery. 27. 1132 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suguru, Sato: "Host's immune reaction from the viewpoint of nalignanay of gastric cencer and lymphocyte subset analysis by flow aytonetry" Mid J kinki Univ. 20. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 今西 幸雄: "Flow cytometryによるDNA ploidy patternとDNA indexからみた胃癌遠隔転移様式の検討" 日本消化器外科学会雑誌. 26. 2395-2400 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 今西 幸雄: "Flow cytometryによる核DNA量解析およびPCNA labeling indexからみた胃癌遠隔転移様式の検討" 近畿大学医学雑誌. 18. 521-532 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐藤 卓: "胃癌のDNA ploidy patternを腫瘍浸潤リンパ球のSobpopututionからみた局所免疫反応" 日本消化器外科学会雑誌. 27. 1132- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐藤 卓: "Flow cytometryによる胃癌悪性度とリンパ球サブセット解析からみた宿主免疫反応" 近畿大学医学雑誌. 20. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 黒岡 一仁: "フローサイトメトリー入門" 日本サイトメトリー学会, 99 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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