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IMMUNOTHERAPY OF MALIGNANT BRAIN TUMORS USING OK-432-ACTIVATED MONONUCLEAR CELLS COMBINED WITH HUMAN MONOCLONAL ANTIBODY AGAINST CANCER

Research Project

Project/Area Number 04670866
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionSAGA MEDICAL SCHOOL

Principal Investigator

ABE Masamitsu  SAGA MEDICAL SCHOOL, FACLUTY OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 講師 (20136427)

Co-Investigator(Kenkyū-buntansha) KIHARA Shunichi  SAGA MEDICAL SCHOOL, FACLUTY OF MEDICINE, LECTURER, 医学部, 助手 (30253610)
TABUCHI Kazuo  SAGA MEDICAL SCHOOL, FACLUTY OF MEDICINE, PROFESSOR, 医学部, 教授 (50116480)
桃崎 宣明  佐賀医科大学, 医学部, 助手 (30239587)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsGlioma / MHC / Immunotherapy / Monoclonal antibody / Cytokine / glioma / immunotherapy / monoclonal antibody / cytokine / CLN-IgG / OK-432 activated killer cell / MHC class I / ^<51>Cr release assay / Flowcytometry / Immunohistochemical stain
Research Abstract

Local administration of OK-432-activated killer (OK-AK) cells has been effective in most patients with malignant brain tumor. In this therapy natural killer(NK) cells are the main effector cells. Recently the inverse correlation between major histocompatibility (MHC) class I expression and susceptibility of target cells to NK cell-mediated lysis has been reported. We exmained the sensitivity of human glioblastoma cells under MHC class I-expressing and the non-expressing conditions.
Our results showed that OK-AK cells exclusively lysed the human gliobalstoma cells and that the susceptibility of glioblastoma cells to NK lysis was markedly reduced by the expression of MHC class I antigens on their cell surface. Human monoclonal antibody against cancer (CLN-IgG) was bound to malignant gliomans more than to low-grade gliomas. The susceptibility of glioblastoma cells with the expression of MHC class I antigens to NK lysis was improved by the administration of CLN-IgG.
The present results indicate that CLN-IgG may enhance the cytocidal effect of OK-AK cells against malignant gliomas.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] 阿部雅光: "先端巨大症とクッシング病に対する定位的陽子線治療" ホルモンと臨床. 40. 110-113 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Momozaki N.: "Suppression of anchorage-independent growth of human glioblastoma by major histocompatibility complex class I genetransfection." J.Neurosurg. 76. 845-849 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 田渕和雄: "神経膠腫の癌遺伝子と癌抑制遺伝子" 医学のあゆみ. 161. 420 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 田渕和雄: "脳腫瘍の遺伝子診断" 脳と神経. 44. 871-879 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tabuchi K.: "Altered structure and expression of the p53 gene in human neuroepithelial tumors." Neurol.Med.Chir.32. 725-732 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 田渕和雄: "脳腫瘍の分子生物学的特性" 脳神経外科. 21. 677-696 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Abe M,Kjellberg RN: "Stereotactic proton beam therapy for acromegaly and Cushing disease." Horumon to Rinshou (Jpn). 40. 110-113 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Momozaki N., Oh-uchida M., Tabuchi K., Ikezaki K.and Hori K.: "Suppression of anchorage-independent growth of human glioblastoma by major histocompatibility complex class I gene-transfection." J.Neurosurg.76. 845-849 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tabuchi K.: "Oncogene and tumor suppressor gene of gliomas." Igakuno Ayumi(Jpn). 161. 420 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tabuchi K., Fukuyama K., Mineta T.: "Gene therapy of brain tumors." Brain Nerve(Jpn). 44. 871-879 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tabuchi K., Fukuyama K., Mineta T., Ohuchida M.and Hori K.: "Altered structure and expression of the p53 gene in human neuroepithelial tumors." Neurol.Med.Chir.32. 725-732 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tabuchi K., Shiraishi T.: "Molucular biological characteristics of brain tumor." Neurol.Surg.(Jpn). 21. 677-696 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 田渕和雄: "脳腫瘍の分子生物学的特性" 脳神経外科. 21. 677-696 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 白石哲也: "抗Fas抗体による培養グリオーマ細胞のapoptosis誘導" 神経化学. 32. 100-102 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sato, T.: "Frontal lobe tumor associated with late-onset seizure and psychosis." Psychiat.Neurol.47. 541-544 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 廣津 辰美: "OK-432賦活化キラー細胞の脳腫瘍細胞障害活性に及ぼす主要組織適合抗原MHC class Iの影響" 神経免疫研究. 4. 151-154 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Momozaki N.: "Suppression of anchorage-independent growth of human glicblastoma cell by major histocompatibility complex class I gene transfection." J.Neurosurg.76. 845-849 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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