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Study of leukocyte function in urinary tract infection

Research Project

Project/Area Number 04670958
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionGifu University

Principal Investigator

KAWADA Yukimichi  Gifu University, School of Medicine, Professor, 医学部, 教授 (00021428)

Co-Investigator(Kenkyū-buntansha) ISHIHARA Satoshi  Gifu University, School of Medicine, Research Associate, 医学部・附属病院, 助手 (00193342)
KIRIYAMA Manabu  Gifu University, School of Medicine, Assistant Professor, 医学部・附属病院, 講師 (30021439)
伊藤 康久  岐阜大学, 医学部, 助手 (50223194)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥900,000 (Direct Cost: ¥900,000)
KeywordsNeutrophile function / Superoxisude / Urinary tract infection / 多核白血球 / 白血球機能 / スーパーオキサイド / 感染防御能
Research Abstract

1) Using urea and NaCl, the effects of blood neutriphiles to superoxiside production in various osmolarities were studied. Under 600 m0sm/kg and <5 mg/ml of urea concentration, the superoxiside production increased. Therefore, both osmolarity and urea concentration must be controlled for the effect.
2) The effects of superoxiside production of new-quinolones were observed in both blood and urinary neutrophiles. These antimicrobial agents inhibited the blocking activity of the osmolarities.
3) Superoxide production of blood netrophiles increased by treatment of G-CSF with its dose dependency. This effect was not observed in using urinary neutrophiles. This function observed in blood neutrophiles was well preserved in higher osmolarity atomosphier if previouly treated by the G-CSF.Therefore, urinary leukocyte activated and migrated from blood may still have the its function.
4) The superoxide production in the patients with neurogenic bladder dysfunction was studied in terms of the presence of infection or indwelling catheter. The groups of apparent infection and the catheter showed strong superoxide production, suggesting the occurrence of urinary tract infection may be following to the condition of decreased self-defense mechanism. Moreover, chronic stage of infectin such as chronic pyelonephritis cases fond lower production suggest to decrease the leukocyte function.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 伊藤雅康,河田幸道 他: "尿中多型白血球(PMNs)に対するG-CSFの作用" (第80回日本泌尿器科学会総会1992年4月東京)日本泌尿器科学会雑誌. 84. 124-124 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masayasu Ito, Manabu Kuriyama, Yoshihito Ban, Yukimichi Kawada, Ken-ichi Kawano, Masayuki Niwa, Masakatsu Nozaki, Kaito Tsurumi, Masayoshi Yamaha, Koichi Tamura: "The effect of G-CSF to urinary molymorpher neutrophiles." The Japanese Journal of Urology (The 80th Annual Congress of Jpn.Urol.Assoc. April/1992, Tokyo). 84 (1). 124 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 伊藤 雅康,河田 幸道 他: "尿中多型白血球(PMNs)に対するG-CSFの作用" (第80回日本泌尿器科学会総会1992年4月東京)日泌尿会誌. 84. 124-124 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 河田幸道: "好中球機能におよぼす尿中浸透圧惹起因子の影響" 日泌尿会誌. (発表投稿予定).

    • Related Report
      1993 Annual Research Report
  • [Publications] 河田幸道: "好中球機能におよぼすG-CSFの影響" 日泌尿会誌. (発表投稿予定).

    • Related Report
      1993 Annual Research Report
  • [Publications] 河田幸道: "尿路感染症患者の好中球機能に関する検討" 日泌尿会誌. (発表投稿予定).

    • Related Report
      1993 Annual Research Report
  • [Publications] 伊藤 雅康,栗山 学,河田 幸道 他: "尿中多核白血球(PMNs)に対するG-CSFの作用" 第80回 日本泌尿器科学会総会.

    • Related Report
      1992 Annual Research Report
  • [Publications] 伊藤 雅康,栗山 学,河田 幸道 他: "尿中多核白血球(PMNs)に対する新キノロン剤およびG-CSFの作用" 第41回 日本泌尿器科学会中部総会.

    • Related Report
      1992 Annual Research Report
  • [Publications] 伊藤 雅康,栗山 学,河田 幸道 他: "新キノロン薬による好中球活性酸素増強作用" 第39回 日本化学療法学会西日本支部総会.

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Kohno,M.Itoh,M.Kuriyama,Y.Kawada et al: "Effect of DR-3355,a novel quinolone,on response of human polymorphonuclear leucocytes" 17th,International Congress of Chemotherapy.

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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