| Project/Area Number |
04670990
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Chiba University |
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Principal Investigator |
FUKASAWA Ichio (1993-1994) Chiba University Hospital Medical instructc, 医学部・附属病院, 講師 (00189911)
岩崎 秀昭 (1992) 千葉大学, 医学部, 講師 (60124244)
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| Co-Investigator(Kenkyū-buntansha) |
INABA Noriyuki Chiba University, Faculty of Medicine Sub-professor, 医学部, 助教授 (70114238)
深沢 一雄 千葉大学, 医学部, 助手 (00189911)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Human papillomavirus / In situ hybridization / Uterine cancer / Dysplasia / Cytology / Histology / Immunohistochemistry / Human Papillomarivus / HPV(Human Papillomavinus) / in situ hybridization(核酸ハイブリダイゼーション) / ヒトパピローマウィルス(HPV) / 子宮頚部 / ハイブリダイゼーション |
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| Research Abstract |
We examined the presence of human papillomavirus (HPV) DNA in uterine cervical lesions by using in situ hybridization method. And the clinical course of HPV DNA positive cases was observed. All 4 cases positive for HPV DNA type 6/11 had regression. In 20 cases positive for HPV 16/18, 13 cases (65%) had progression, 5 cases (25%) had no change and 2 cases (10%) had regression. Progression was seen in 25% of HPV 31/33/35 positive cases, in 25% of HPV 51/52 cases and in 29% of HPV 58 cases. It was concluded that from the clinical viewpoint HPV 6/11 positive cases have a low risk for progression, HPV 16/18 cases have a high risk and HPV 31/33/35, 51/52 and 58 cases have a intermediate risk.
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