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Human papillomavirus (HPV) detection and a follow up study of HPV positive cases

Research Project

Project/Area Number 04670990
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionChiba University

Principal Investigator

FUKASAWA Ichio (1993-1994)  Chiba University Hospital Medical instructc, 医学部・附属病院, 講師 (00189911)

岩崎 秀昭 (1992)  千葉大学, 医学部, 講師 (60124244)

Co-Investigator(Kenkyū-buntansha) INABA Noriyuki  Chiba University, Faculty of Medicine Sub-professor, 医学部, 助教授 (70114238)
深沢 一雄  千葉大学, 医学部, 助手 (00189911)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
KeywordsHuman papillomavirus / In situ hybridization / Uterine cancer / Dysplasia / Cytology / Histology / Immunohistochemistry / Human Papillomarivus / HPV(Human Papillomavinus) / in situ hybridization(核酸ハイブリダイゼーション) / ヒトパピローマウィルス(HPV) / 子宮頚部 / ハイブリダイゼーション
Research Abstract

We examined the presence of human papillomavirus (HPV) DNA in uterine cervical lesions by using in situ hybridization method. And the clinical course of HPV DNA positive cases was observed. All 4 cases positive for HPV DNA type 6/11 had regression. In 20 cases positive for HPV 16/18, 13 cases (65%) had progression, 5 cases (25%) had no change and 2 cases (10%) had regression. Progression was seen in 25% of HPV 31/33/35 positive cases, in 25% of HPV 51/52 cases and in 29% of HPV 58 cases. It was concluded that from the clinical viewpoint HPV 6/11 positive cases have a low risk for progression, HPV 16/18 cases have a high risk and HPV 31/33/35, 51/52 and 58 cases have a intermediate risk.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Iwasaki H.: "Detection typing and localization of human papillomariaus by in situ hybridization." J.Clin.Electron Microscopy. 25. 5-6 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 岩崎秀昭: "HPV感染例のprospectiveな検索-Vira Type^<TM>を用いて-" 医学と薬学. 27. 55-60 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 計良恵治: "子宮頚部病変におけるIn situ hybridization法によるHuman prpillomevirus DNA検出例のprospective,retropoctiveな検索" 産婦人科の実際. 41. 839-847 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 岩崎秀昭: "子宮頚癌とHPV" 臨床婦人科産科. 47. 1396-1398 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 岩崎秀昭: "妊娠時感染症チェックの仕方-性器感染ウイルス:ヒトパピローマウイルス(HPV),単純ヘルペスウイルス(HSV)" 産科と婦人科. 60. 489-494 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 計良恵治: "in situ hybridization法によるhuman papillomavirus DNAの検出" 病理と臨床. 12. 231-238 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] IWASAKI,H: "Detection typing and localization of human papillomavirus by in situ hybridization." J Clin Elecron Microscopy. 25. 5-6 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] IWASAKI,H: "A prospective study of HPV positive cases -by using Vira Type ^<TM>-." Medicine and Pharmacy. 27. 55-60 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] KERA,K: "Prospective and retrospective studies of HPV DNA positive cases in uterine cervical lesions by using in situ hybridization method." Obst Gynec Practice. 41. 839-847 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] IWASAKI,H: "Uterine cervical cancer and HPV." Clinical Gynec Obst. 47. 1396-1398 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] IWASAKI,H: "How to check for viral infection during pregnancy -HPV and HSV." Obst Gynec. 60. 489-494 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] KERA,K: "HPV DNA detection by in situ hybridization." Pathol Clinic. 12. 231-238 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Iwasaki H.: "Detectirn-cyping and localization of human papillomarvrus by in situ hybridization." J.Clin.Electron Microscopy. 25. 5-6 (1992)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岩崎秀昭: "HPV感染例のProszectiveな検索 -Vira Type^<TM>を用いて-" 医学と薬学. 27. 55-60 (1992)

    • Related Report
      1994 Annual Research Report
  • [Publications] 計良恵治: "子宮頚部組織におけるIn situ hybridization法によるHuman Papillomarivus DNA 検出例のProszective,retrozectiveな検索" 産婦人科の実際. 41. 839-847 (1992)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岩崎秀昭: "子宮頚癌とHPV" 臨床婦人科産科. 47. 1396-1398 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岩崎秀昭: "妊娠時感染症チェックの仕方-性器感染ウイルス:ヒトパピロースウイルス(HPV).単純ヘルペスウイルス(HSV)" 産科と婦人科. 60. 489-494 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 計良恵治: "in situ hybridization法によるhuman Papillomarivus DNAの検出" 病理と臨床. 12. 231-238 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岩崎 秀昭: "HPV感染例のProspectiveな検査-ring Type TM-を用いて" 医学と薬学. 27. 55-60 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 計良 恵治: "子宮頚部組織に対するISH法・によるHPV DNA検出例のProspective,retrospectiveな検査" 産婦人科の実際. 41. 839-847 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 堀内 文男: "子宮頚部病変におけるHPV-DNA局在と組織学的診断" 日本臨床細胞学会雑誌. 31. 444-449 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岩崎 秀昭: "コルポスコピーの実際" 日本産科婦人科学会雑誌. 44. 165-168 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岩崎 秀昭: "ヒトパピローマウィルス(HPV)と単純ヘルペスウィルス" 産科と婦人科. 61. (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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