| Co-Investigator(Kenkyū-buntansha) |
IKEDA Toshiyuki Keio University, Assistant, 医学部, 助手 (80222892)
MASUZAWA Toshihede Keio University, Assistant, 医学部, 助手 (80229369)
MAKITA Kazuya Keio University, Assistant, 医学部, 助手 (80219302)
SUDA Yoshio Keio University, Assistant, 医学部, 助手 (00216475)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1992: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Research Abstract |
Enodocinological dynamics, bone metabolism and bone mineral density (BMD) were and analyzed to study whether or not there aer pathological differences in osteoporosis following menopause and that following oophorectomy. Subjects in whom a mean period of 3 years had passed since menopause or oophorectomy, a time when effects on vone metabolism should be evident, were studied, Levels of androstenedione and e_1, considered to have a fanorable effect on bone matabolism, were significantly higher in menopausal subjects compared with subjects undergoing oopherectomy. Howeever, steroid dominance in the menopausal subjects was not reflected in bone metabolism. Nosignificant dirrerence in BMD was detected between the two subject groups by any determination method (MD, QCT, DPA, DXA) or for any site measured (peripheral bone/axial bone, travecular bone/cortical bone). Therefore, osteoporesis associated with oophorectomy, causing drastic changes in bone, ws clinically considered to be comparable to osteoporosis associated with the physiological phenomenon if menopause. However, clinical heterogeneity in junan subjects may mask fine individual differences in the response of bone to menopause and oophorectomy. Invitro research is therefore necessary, Although only preliminary results are available, we have noted quantitative and qualitative differnces in the response of bone marrow cells to oophorectomy. These findings will be followed up by future reseatch.
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