| Project/Area Number |
04671044
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kagawa Medical School |
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Principal Investigator |
MIYAGUCHI Mamoru Kagawa Medical School・School Hospital Assistant professor, 医学部・附属病院, 講師 (70166130)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Junji Kagawa Medical School・School Hospital Instructor, 医学部・附属病院, 助手 (40236469)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1992: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Maxillary sinus / Squamous cell carcinoma / Epidermal growth factor receptor / Local recurrence / 完疫組織化学 / 画像解析 / フローサイトメトリー / 放射線感受性 / 上顎洞癌 / 培養細胞 / 免疫組織化学 |
|---|
| Research Abstract |
The expression of epidermal growth factor receptor (EGFR) was determined immunohistochemically in two groups of maxillary sinus squamous cell carcinomas, one with recurrences at the primary site after combination therapy with radiotherapy, chemotherapy and / or surgery and one without local recurrences. Using a four-graded scale(-, +, ++, +++), 9 of the 10 recurrent carcinomas had a staining intensity and proportion of stained cells of ++ or more. A comparable staining intensity was found in 9 of the 18 non-recurrent carcinomas. This difference is statistically significant (Fisher's exact probability test, P<0.05). These results indicate that an increased expression of EGFR may influence the recurrence rate of squamous cell carcinoma of the maxillary sinus after combined therapy.
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