| Project/Area Number |
04671071
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
WATANABE Ikuo Hamamatsu University School of Medicine, Department of Ophthalmology, Professor, 医学部, 教授 (50107827)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Masaru Hamamatsu University School of Medicine, Department of Ophthalmology, Assistant, 医学部, 講師 (60161121)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Electrooculogram / EOG / recording system / pigmented rabbit / albino rabbit / anesthetics / 家兎眼電図 / 記録条件 / 麻酔薬 / ヨーソ酸ソーダ / 高浸透圧剤 / 網膜色素上皮 / 眼電位図 / 家兎 |
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| Research Abstract |
We investigated to establish an EOG recording system in rabbit. With a rotary-solenoid, rotary movement of the eye could be obtained. Under the frequency of eye movement of less than 90/min, EOG recordings were possible for several hours only with topical anesthesia of the eye. In pigmented rabbits, the EOG L/D ratio was 1.96 (〕SY.+-.〔) 0.42, and in albino rabbits 1.78 (〕SY.+-.〔) 0.48. A positive deflection and a following negative one (fast oscillation) of EOG amplitude just after the initiation of light adaptation were coincident in the time course with the c-wave and the fast oscillation of the DC-ERG.Ethyl carbamate intraperitoneal injection slightly decreased the EOG amplitude but pentobarbital sodium intravenous injection slightly increased EOG amplitude, without statistical significance. Intravenous injection of sodium iodate obscured the fast oscillation and completely suppressed the light rise. After an intravenous injection of D-mannitol, the EOG amplitude decreased 24 (〕SY.+-.〔) 9.8%, compared with the amplitude before the injection. The investigations on the phototoxicity of the rabbit retina are in progress.
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