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Outflow facility : conventional and unconventional flow

Research Project

Project/Area Number 04671076
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionYamaguchi University School of Medicine

Principal Investigator

SUZUKI Ryo  Yamaguchi University School of Medicine Department of Ophthalmology Associate Professor, 医学部, 助教授 (50163027)

Co-Investigator(Kenkyū-buntansha) SUGIHARA Itsuko  Yamaguchi University School of Medicine Assistant Professor, 医学部, 講師 (00162884)
FUKUMOTO Tetsuo  Yamaguchi University School of Medicine Department of Anatomy, 医学部, 教授 (00040171)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsglaucoma / outflow facility / intraocular pressure / animal eye / ciliary muscle / conventional flow / 毛様体 / 隅角 / 房水流出 / 房水 / caffeineカフェイン / ピロカルピン / トーヌス
Research Abstract

To further understand the aqueous outflow mechanism, we examined the action of a variety of several drugs on the outflow facility, contraction of intraocular muscle tissues and cell shape change of bovine trabecular meshwork.
A device capable of perfusing 10 eyes in parallel was made. It consisted of a set of 2ml nerrow-tipped pipetts held horizontally in a wooden frame. Changes in the outflow facility of perfused eyes and in the shape of cells in cultured trabecular meshwork were studied after exposure to several types of drugs including cell cytoskeleton acting drugs and autonomic drugs. Contraction of the isolated intraocular muscle tissues were measured isometrically.
Muscarinic M3 receptor was dominant in the bovine ciliary muscle. Moxisylyte hydrochloride, an 1 -adrenoceptor-blocking agent previously called thymoxamine works by competitive antagonism of norepinephrine. The drug causes miosis without affecting the intraocular pressure or the ciliary muscle-controlled facility of outflow, and we examined the effects. Furthermore, adrenergic 2 receptor activation located at the nerve terminals of bovine ciliary muscle inhibited the contraction of the cholinergically innervated muscle. M3 receptor and pre-synaptic 2 receptor play an important role in the ciliary muscle. The efficacy of our laser traabeculostimulation was compared with that of conventional laser trabeculectomy. Although our laser trabeculostimulation was less effective(60%) than lasertrabeculoplasty, the trial may lead to the development of another useful treatment modality.
Although further discussion must await additionl data, these results suggest that the changes in outflow facility and the accompanying ciliary muscle response and cell shape cahnge may be closely related to each other.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Suzuki R Yoshino H,Kurimoto S: "Laser trabeculostimulation in open-angle glaucoma:a new trial" Ophthalmol. 205. 1-6 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki R Sugihara I Kurimoto S: "Effects of moxisylyte hydrochloride on the retinal circulation of patients with diabetes mellitus" Ophthalmic Research. 24. 274-279 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki R: "A temperature dependent action of fluoride on aqueous outflow facility of the eye." Current Eye Research. 12. 1-7 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki R Yoshino H: "Effects of phosphodiesterase inhibitors on outflow facility" J Ocular Pharmacol. 8. 99-105 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 鈴木亮: "隅角.水晶体.角膜の手術眼科手術図譜" Atlas of Ophthalmic Surgery Heilman and Paton の訳書. 単行本. 1-245 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki R, Yoshino H, Kurimoto S: "Laser trabeculostimulation in open-angle glaucoma a new trial" Ophthalmol. 205. 1-6 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshino H, Suzuki R: "Effect of phosphodiesterase inhibitors on bovine ciliary muscle and outflow facility" J Ocular Pharmacol. 8. 99-105 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki R, Sugihara I, Kurimoto S: "Effects of moxisylyte hydrochloride on the rotinal circulation of parents with diabetes mellitus" Ophthalm Research. 24. 274-279 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki R: "A temperature dependent action of fluoride on aqueous outflow facility of the calf eye" Curr Eye Res. 12. 1-7 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki R, Kurimoto S, Fujiwara N: "Astigmatism after phacoemulsification and aspiration procedures" BENT versus standard incisions. Ophthalmol. 205. 131-137 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kubo C, Suzuki R: "Ivolvement of prejunctional alphaz-adrenoceptor in bovine ciliary muscle movement" J Ocular Phamacol. 8. 225-231 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki R, Sugihara I: "Retinal circulation in primary open-angle glaucoma tested by videodensitometric image analysis" Annals Ophthalmol. 24. 273-277 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki R, Nakayama M, Yoshino H: "Comparison of laser trabeculostimulation with laser trabeculoplasty in open angle glaucoma" Annals Ophthalmol. 24. 245-250 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki R: "A temperature dependent action of fluoride on aqueous outflow facility of the calf eye." Current Eye Research. 12. 1-7 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Suzuki R,Yoshino H: "Effects of phosphodiesterase inhibitors on outflow facility." J Ocular Pharmacol. 8. 99-105 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 鈴木亮: "眼科手術図譜、隅角(全9章)他。Atlas of Ophthalmic Surgery Heilman and Paton Dの訳書" 眼科手術図譜(Heilman & Paton)Thieme社. 単行本. 1-245 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Suzuki R. Yoshino H,Kunimoto,S: "Laser tabeculostimulation in open-angle glaucomg:a new tial." Ophthalmol. 205. 1-6 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshino H Suzuki R: "Effect of phosphodiesterare inhibitors on bovine ciliary muscle and ontflow facility." J Owlar pharmacol. 8. 99-105 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Suzuki R Sugihara I,Kunimoto,S: "Effects of moxisylyte hydrochloride on the natinal circulation of patiento with dialetes mellitus." Ophtlialm Research. 24. 274-279 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 相良 健,鈴木 亮,盧 奈津江,栗本 晋二: "内眼筋と房水流出率に及ぼす硝子体の効果について" 日本眼科紀要. 43. 382-385 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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