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Clinical appilication of video infrared fluorescein angiography to improve results of laser photocoagulation for senile disciform macular degeneration

Research Project

Project/Area Number 04671086
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionNihon University

Principal Investigator

YUZAWA Mitsuko  Nihon University, School of Medicine, Lecturer, 医学部, 講師 (60139160)

Co-Investigator(Kenkyū-buntansha) KAWAMURA Akiyuki  Nihon University, School of Medicine, Assistant, 医学部, 助手 (90214692)
HAGITA Katsuhiko  Nihon University, School of Medicine, Assistant, 医学部, 助手 (10189459)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsAge-related Macular Degeneration / Choroidal Neovascularization / Indocyanine Green Angiography / Fluorescein Angiography / Laser Photocoagulation / 黄斑部脈絡膜新生血管 / インドシアニングリーン蛍光眼底造影 / フルオレセイン蛍光眼底造影
Research Abstract

1. We performed fluorescein angiography (FA) and indocyanine green video-angiography (IA) to detect choroidal neovascular membranes (CNVs) associated with senile disciform macular degeneration. we evaluated the clinical reliability of IA as a pretreatment examination for laser photocoagulation. The results were as follows :
(1) IA was especially useful for eyes with extensive subretinal hemorrhage and/or exudative detachements of the retinal pigment epithelium.
(2) Based on the IA findings, some choroidal neovascular membranes were obliterated with laser photocoagulation.
(3) Some well-defined CNV,which were detectable with FA,showed four distinct findings on IA.The first consisted of the typical findings shown on FA.The second was slow filling with hypofluorescence in the early Phase of IA.The third was no leakage, i.e., little or no leakage from the CNV in the later phase of IA.In the fourth type, the CNV could not be demonstrated with IA.
(4) We need careful evaluation on IA findings to improve the successful results when findings in FA and IA differed.
2. Feeder vessel were visible in some areas of subfoveal choroidal neovascularization on indocyanine green video-angiography. We thus attempted feeder vessel treatment on eight eyes in hopes of avoiding foveal photoreceptor destruction. Additional treatments were required in seven eyes, 5 of which developed scar tissue without edema. Even though we observed decreased leakage immediately after treatment in all cases, three eyes required photocoagulation of the entire CNV due to persistent fluorescein leakage from a subfoveal CNV.When feeder vessels are detected, it is advisable to treat the feeder vessels before coagulating the subfoveal CNV.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] Mitsuko,Yuzawa.: "Clinical evaluation of indocyanine green video-angiography in the diagnosis of choroidal neovascular membrane associated with age-related macular degeneration." European Journal of Ophthalmology. 2. 115-121 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 湯沢,美都子: "老人性円板状黄斑変性症の光凝固" 眼科手術. 6. 695-700 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 湯沢,美都子: "老人性円板状黄斑変性症" 現代医療. 26. 535-541 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 川村,昭之: "脈絡膜新生血管板の栄養血管に対する光凝固" 臨床眼科. 48. 565-568 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 湯沢,美都子: "老人性円板状黄斑変性症の臨床的研究" 日本医学雑誌. 53. 381-384 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 湯沢,美都子: "網膜色素上皮剥離のICG螢光眼底造影所見" 臨床眼科. 49. 73-81 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 湯沢,美都子(分担執筆): "眼科診療プラクティス2眼底の描き方(黄斑疾患,インドシニアグリーン螢光造影)" 文光堂, 7(43〜47,212〜213) (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 湯沢,美都子(分担執筆): "眼科学アップデイト(加齢黄斑疾変性症)" 診断と治療社, 7(13〜19) (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 湯沢,美都子(分担執筆): "眼科診療プラクティス6眼底造影写真の読み方(ドル-ゼンと老人性円板状黄斑変性症)" 文光堂, 6(98〜106) (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 川村,昭之(分担執筆): "眼科学アップデイト(ICG螢光造影)" 診断と治療社, 6(83〜88) (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 湯沢,美都子(分担執筆): "眼科学大系5Bレーザー眼科(黄斑下新生血管症)" 中山書店, 13(217〜229) (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mitsuko Yuzawa: "Clinical evaluation of indocyanine green video-angiography in the diagnosis of choroidal nevascular membrane associated with age-related macular degeneration" European Journal of Ophthalmology. 2. 115-121 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mitsuko Yuzawa: "Laser photocoagulation treatment for senile disciform macular degeneration" Japanese Journal of Ophthalmic Surgery. 6. 695-700 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mitsuko Yuzawa: "Senile disciform macular degeneration" Gendai Iryo. 26. 535-541 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Akiyuki Kawamura: "Laser photocoagulation treatment for feeder vessel of choroidal neovascular membrance" Japanese Journal of Clicical Ophthalmology. 48. 565-568 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mitsuko Yuzawa: "Clinical study on senile disciform macular degeneration" The Nihon University Journal of Medicine. 53. 381-384 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mitsuko Yuzawa: "Indocyanine green video-angiography in detachment of retinal pigment epithelium" Japanese Journal of Clinical Ophthalmology. 49. 73-81 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mitsuko Yuzawa: Practial Ophthalmology 2. (Macular diseases, Indocyanine green angiography). Bunkodo, 43-47, 212-213 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mitsuko Yuzawa: Ophthalmology Up Date. (Age-related macular degeneration). Shindan-to-Chiryo Sha, 13-19 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mitsuko Yuzawa: Practical Ophthalmology 6. (Drusen and senile disciform macular degeneration). Bunkodo, 98-106 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Akiyuki Kawamura: Ophthalmology Up Date. (ICG angiography Ophthalmology). Shindan-to-Chiryo Sha, 83-88 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mitsuko Yuzawa: Current Encyclopedia of Ophthalmology 5B.(Submacular neovascular maclopathy). Nkayama-Shoten, 217-229 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 川村,昭之: "脈絡膜新生血管板の栄養血管に対する光凝固" 臨床眼科. 48. 565-568 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 湯沢美都子: "老人性円板状黄斑変性症の臨床的研究" 日大医学雑誌. 53. 381-384 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 湯沢美都子: "網膜色素上皮剥離のICG蛍光眼底造影所見" 臨床眼科. 49. 73-82 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 湯沢美都子(分担執筆): "「眼科学大系5B レーザー眼科」黄斑下新生血管症" 中山書店, 13 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 湯沢美都子: "老人性円板状黄斑変性症の光凝固" 眼科手術. 6. 695-700 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 湯沢美都子: "老人性円板状黄斑変性症" 現代医療(Vp Date 早期診断とその対応). 26. 535-541 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 川久保洋: "中心嵩網膜下新生血管板の光凝固の有用性" 眼科紀要. 44. 1145-1151 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 川久保洋: "老人性円板状黄斑変性症の自然寛解例" 眼科紀要. 44. 894-898 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 湯沢美都子(分担執筆): "文光堂" 眼科診療プラクティス6 眼底造影写真の読み方」ドルーゼンと老人性円板状黄斑変性症. 9 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 湯沢美都子(分担執筆): "診断と治療社" 「眼科学アップデイト」加齢黄斑変性症. 7 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 湯沢 美都子: "老人性円板状黄斑変性症" 医学のあゆみ. 160. 234 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 湯沢 美都子,川村 昭之, 中島 正巳, 正田 美穂, 松井 瑞夫: "ビデオ赤外蛍光造影の臨床応用 老人性円板状黄斑変性症の初回光凝固" 厚生省特定疾患網膜脈絡膜萎縮症調査研究班 平成3年度研究報告書. 152-155 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 湯沢 美都子, 中島 正巳, 川村 昭之, 高橋 信仁, 正田 美穂 ,松井 瑞夫: "脈絡膜新生血管を伴う大型の色素上皮剥離のレーザー光凝固成績" 厚生省特定疾患網膜脈絡膜萎縮症調査研究班 平成3年度 研究報告書. 170-173 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M. Yuzawa, A. Kawamura, M. Matsui: "Clinical evaluation of indocyanine green videoangiography in the diagnosis of choroidal neovascular membrane associated with age-related macular degeneration." European Journal of Ophthalmology. 2. 115-121 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 湯沢 美都子: "黄斑部の加令変化" 日本の眼科. 63. 1317 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 湯沢 美都子: "新生血管黄斑症の発生機序と最近の治療法" 日本の眼科. 63. 55-56 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 湯沢 美都子(分担執筆): "「眼科診療プラクティス 2 眼底の描き方」 黄斑疾患,インドシアニングリーン螢光眼底造影" 文光堂, 212-213 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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