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Detection of HBV and HCV by PCR in Saliva

Research Project

Project/Area Number 04671109
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionNihon University

Principal Investigator

KOMIYAMA Kazuo  Nihon University School of Dentistry, Department of Pathology Associate Professor, 歯学部, 助教授 (00120452)

Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1992: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsHBV / HCV / PCR / Southern hybridization / Saliva / RT-PCR / B型肝炎ウイルス / C型肝炎ウイルス / 唾液
Research Abstract

Both of HBV and HCV are major cosative pathogen for hepatitis. It is well known that these virus were often transmitted by blood. Human saliva occasionally contains various viral agents including hepatitis virus, suggesting a possible source of hepatitis virus infection through saliva. In addition, dental practice led to bleeding during tooth extraction or treatment for periodontitis. During treatment or after remission of hepatitis patients sometimes visit dental clinics for the treatment of oral disease. We have examined the presence of HBV and HCV by PCR in the saliva of patients with various liver condition including chronic hepatitis. Occult blood contained saliva of these patients(75%). HBV was detected in high ratio among healthy carrier(75%), not only for chronic hepatitis patients(42%). HCV was often deteced in chronic hepatitis(35%), liver chirrhosis(73%) and hepatoma(35%) patient. HCV also positive for saliva from dental patient(50%). It is thus clear that HBV and HCV have been detected in the saliva of patient with various liver condition who under treatment for oral disease and dentist shoud aware of the possibility of HBV and HCV infection via saliva contactd during oral treatment.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 松田由紀子: "Polymerase chain Reaction法を用いたB型肝炎ウイルスの検出" 日大歯学. 66. 638-649 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小宮山 一雄: "肝炎ウイルス研究の現況-C型肝炎を中心に-" 東京都歯科医師会雑誌. 41. 245-252 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yumiko Matuda: "Detection of HBV-DNA by Polymerase Chain Reaction" Nihon University Dental Journal. 66. 638-649 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazuo Komiyama: "HCV research up to date" The Journal of the Tokyo Dental Association. 41. 245-252 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 松田由紀子: "Polymerase Chain Reaction法を用いたB型肝炎ウイルスの検出" 日大歯学. 66. 638-649 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小宮山一雄: "肝炎ウイルス研究の現況-C型肝炎を中心に-" 東京歯科医師会誌. 41. 245-252 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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