| Project/Area Number |
04671156
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ODA Shigeru Fac.of Dent., Tokyo Med. & Dent.Univ., Lecturer, 歯学部, 講師 (70160869)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Atsuhiro Fac. of Dent., Tokyo Med. & Dent. Univ., Instructor, 歯学部, 助手 (10242207)
UOSHIMA Mariko Fac.of Dent., Tokyo Med. & Dent.Univ., Instructor, 歯学部, 助手 (50228425)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Biphasic Calcium Phosphate / Hydroxyapatite / beta-tricalcium Phosphate / Macrophage / Rat / Monkey / BCP / HA / β-TCP |
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| Research Abstract |
Various types of graft materials have been used in periodontal therapy to facilitate the regeneration of attachment apparatus sufferd from predominately diseases. We considered that bioresorbable ceramics, biphasic calcium phosphate(BCP) granules, needed to be formatted for clinical use. The BCP is consisted of beta-tricalcium phosphate and hydroxyapatite uniformly in a granule.
The purpose of the first study was to observe histologically the degradation process of the BCP granules and the bone formation process after the implantation into bone defects of rat calvaria. The second study was to evaluate the periodontal regeneration after the BCP implantation into the alveolar bone defects of monkeys.
In the first study, many polynucleated giant cells were observed near some of the BCP granules at one week. Many macrophages which contained small particles of the granules within their vesicles were also observed, The longer the observation period was, the more the BCP granules were collapsed. Some granules were remained within the newly formed bone derived from the bone wall at 32 weeks.
In the second study, three months after the implantation, it was observed that the BCP granules had been phagocytized by macrophages and replaced by new bone, and that calcified new cementum was considerably deposited on the root surfaces.
Consequently, it was suggested that the BCP granules was applicable for periodontal regeneration as a bone substitute since they had biocompatibility and bioresorbability.
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