| Project/Area Number |
04671180
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
補綴理工系歯学
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
FUJISAWA Seiichiro TOKYO MED.& DENT.UNV.ASSOCIATE PROFESSOR, 歯学部, 助教授 (40014162)
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| Co-Investigator(Kenkyū-buntansha) |
KOMODA Yasuo TOKYO MED.& DENT.UNV.PROFESSOR, 医用器材研究所, 教授 (60012639)
KADOMA Yoshinori TOKYO MED.& DENT.UNV.PROFESSOR10DA02 : 60012639, 医用器材研究所, 助教授 (00092403)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Bentoyl peroxide / Polymenzation of wotheylweloerlate / Induction periode / radical scaverzing / Initial rate of polipenzation / antioxidants / Vitamin E / beta-carotene / BPO / ユ-ジノール / ビタミンA / レジン系歯科材料 / ラジカル連鎖移動 / フェノール誘導体 / レチノール / 誘導期 / メチルメタクリレート / 禁止剤 / フェノール類 / 初期重合率 / アゾビスイソブチロニトリル |
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| Research Abstract |
Benzoyl peroxide (BPO) is widely used as initiator of MMA polymerization of prosthetic devices. Peroxide radicals induced by BPO may cause the damage of oral mucosa due to lipid peroxidation of biological membranes. Antioxidants such as vitamin E,beta-carotene etc. act as radical scavengers. In this experiments, DSC polymerization was carried out in the presence of vitamin E,vitamin A,and beta-carotene which are mixed in MMA at various concentration . When the concentration of vitamin E increased, induction periode (IP) increased, whereas initial rate of poly merization (IRP) decreased. On the other hand, vitamin A did not change in both IP and IRP at high concentration. beta-carotene inhibited the polymerization of MMA at 0.5 mole%.
alpha-tocopherol (chain breaking) and beta-carotene (radical trapping) showed strong radical scavenging effect.
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