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Electron microscopic study on oral manifestations of human immunodeficiency virus infection

Research Project

Project/Area Number 04671234
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionKAGOSHIMA UNIVERSITY

Principal Investigator

SUGIHARA Kazumasa  Kagoshima University first Department of Oral & Maxillofacial Surgery, associate Professor, 歯学部, 助教授 (00117516)

Co-Investigator(Kenkyū-buntansha) KUNIYOSHI Hideharu  Kagoshima University First Department of Oral & Maxillofacial Surgery, Assistant, 歯学部・附属病院, 助手 (50244249)
石神 哲郎  鹿児島大学, 歯学部, 助手 (30232276)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsHIV-infection / Oral manifestation / Oral candidiasis / Oral hairy leukoplkia / Intraoral Kaosi's sarcoma / Electron microscopic study / Epstein-Barr virus / 電子顕微鏡学的研究
Research Abstract

Oral manifestations in HIV infection are numerous and some of these have been acknowledged as bing of great importance in early diagnosis of the disease. Oral manifestations in HIV-infected individuals occurred as mycotic, bacterial or viral infection, neoplasm or unknown etiology. Oral candidiasis occurring as pseudomembranous, hyperplastic and erythematous types should be considered. Oral hairy leukoplakia is characterized by whitish plaques at the lateral border of the tongue which cannot be rubbed off. Light microscopic investigations indicated that the lesion is characterized by parakeratosis, acanthosis, koilocytosis and lack of inflammation in the subepithelial tissue. Using electron microscopy, particles of the herpes virus group(Epstein-Barr virus) were found in the upper two thirds of the epithelium in this lesion.Oral hairy leukoplakia is an early sign of HIV infection and its importance relates to the development of AIDS(mostly Pneumocystis carinii pneumonia) in 83% of the affected patients within 31 months after its diagnosis. Electron microscopic study on intraoral Kaposi's sarcoma showed proliferating endothelial cells protruded into the lumen of the vascular space in the flat lesions. Exophytic lesions consisted of elongated spindle tumor cells and cleft-shaped, vessel-like lumina. Spindle tumor cells were characterized by intercellular junctions and Weibel-Palade bodies.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 杉原一正他5名: "HIV感染症患者にみられた口腔毛状白板症の2例" 日本口腔外科学会雑誌. 40. 170-172 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 杉原一正: "ヒト免疫不全ウィルス感染症患者の口腔病変-とくに口腔毛状白板症と口腔カポジ肉腫について-" 鹿児島大学歯学部紀要. 14. 13-24 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazumasa SUGIHARA, Kenju ARIMURA, Yasushi IWASHIGE, Kiyomi KAWASHIMA, Akiro OHKUBO, Sukehide YAMASHITA: "Two cases of oral hairy leukoplakia in HIV-infected patients" Japanese Journal of Oral and Maxillofacial surgery. 40(1). 170-172 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazumasa SUGIHARA: "Oral manifestations of HIV-infected patients ; With special reference to oral hairy leukoplakia and intraoral Kaposi's sarcoma" The Annals of Kagoshima University Dental School. 14. 13-24 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 杉原一正他5名: "HIV感染症患者にみられた口腔毛状白板症の2例" 日本口腔外科学会雑誌. 40. 170-172 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 杉原一正: "ヒト免疫不全ウィルス感染症患者の口腔病変-とくに口腔毛状白板症と口腔カポジ肉腫について-" 鹿児島大学歯学部紀要. 14. 13-24 (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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