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Search and utilization of novel immunosuppressive components from Basidiomycetes

Research Project

Project/Area Number 04671284
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionChiba University

Principal Investigator

FUJIMOTO Haruhiro  Chiba Univ. Fac. Pharm. Sci., Assoc. Prof, 薬学部, 助教授 (50089603)

Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1992: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsMushroom / Basidiomycete / Immunosuppressant / Lactarius flavidulus / Pisolithus tinctorius / Microporus flabelliformis / Lenzites betulina / Structure-activity relationship / 24-methyllanostane / ergosterol peroxide / キノコ代謝産物 / 免疫抑制物質 / ゲラニルフェノール / flavidulol
Research Abstract

In our screening program on immunosuppressive principles of mushrooms (Basidiomycetes), we fractionated the crude extracts of Lactarius flavidulus, Pisolithus tinctorius, Microporus flabelliformis and Lenzites betulina under moniroting their immunosuppressive actibities against mitogen-induced proliferation ( ; lastogenesis) of mouse spleen lymphocytes, and isolated their immunosupperssive principles. Three immunosuppressive vomponents from L.flavidulus tentatively named LF-1, -2 and -3 were indentified with geranylphenols, flavidulols A, B and C, respectively, which had formerly been isolated from the same mushroom (flavidulol A had formerly been isolated as an anti-microbial pronciple from the mushroom). Five immunosuppressive components from P.tinctorius tentatively named PT-1, -2, -3, -4 and -5 were also characterized as follows. PT-1 and -2 were deduced to be 24-methyllanosta-8, 24(28)-diene-3beta, 22zeta-diol and pisolactone ](22S)-24-methllanosta-8-en-22, 28-epoxy-3beta-ol-28-one], which were formerly isolated from the same nushroom. PT-3 was deduced tove a mixture of two novel isomeric compounds related to pisolactone. PT-4 and -5, which were identical with immunosuppressive components from both M.flabelliformis and L.betulina, were identified with ergosterol peroxide and 9(11)-dehydroergosterol peroxide, respectively. These seven components except for ergosterol perxide were isolated spectively. These seven components except for ergosterol peroxide were isolated this time as immunosuppressive principles for the first time. Structure-activity relatioonship on these eight immunosuppressive components was also investigated.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Haruhiro Fujimoto,Yasuhiro Takano and Mikio Yamazaki: "Isolation,Identification and Pharmacological Studies on Three Toxic Metabolites from a Mushroom,Hebeloma spoliatum" Chem.Pharm.Bull.40. 869-872 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Haruhiro Fujimoto,Yuji Nakayama and Mikio Yamazaki: "Identification of Immunosuppressive Components of a Mushroom,Lactarius flavidulus" Chem.Pharm.Bull.41. 654-658 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Haruhiro Fujimoto,Masako Ikeda,Kazumi Yamamoto and Mikio Yamazaki: "Structure of Fischerin,A New Toxic Metabolite from an Ascomycete,Neosartorya fischeri var.fischeri" J.Nat.Products. 56. 1268-1275 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Haruhiro Fujimoto,Megumi Nakayama,Yuji Nakayama and Mikio Yamazaki: "Isolation and Characterization of Immunosuppressive Components of Three Mushrooms,Pisolithus tinctorius,Microporus flabelliformis and Lenzites betulina" Chem.Pharm.Bull.42. 694-697 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Haruhiro Fujimoto, Yasuhiro Takano and Mikio Yamazaki: "Isolation, Identification and Pharmacological Studies of Three Toxic Metabolites from a Mushroom, Hebeloma spoliatum" Chem. Pharm. Bull.40. 869-872 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Haruhiro Fujimoto, Yuji Nakayama and Mikio Yamazaki: "Identification of Immunosuppressive Components of a Mushroom, Lactarius flavidulus" Chem. Pharm. Bull.41. 654-658 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Haruhiro Fujimoto, Masako Ikeda, kazumi Yamamoto and Mikio Yamazaki: "Structure of Fischerin, A New toxic Mtabolite form an Ascomycete, Neosartorya fischeriver. fischeri" J.Nat. Products. 56. 1268-1275 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Haruhiro Fujimoto, Megumi Nakayama, Yuji Nakayama and Mikio Yamazaki: "Isolation and Characterization of Immunosuppressive Components of Three Mushrooms, Pisolithus tinctorius, Microporus flabelliformis and Lenzites betulina" Chem. Pharm. Bull.42. 694-697 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Fujimoto,Y.Takano,and M.Yamazaki: "Isolation,Identification and Pharmacological Studies on Three Toxic Metabolites from a Mushroom,Hebeloma spoliatum" Chem.Pharm.Bull.40. 869-872 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Fujimoto,Y.Nakayama and M.Yamazaki: "Identification of Immunosuppressive Components of a Mushroom,Lactarius flavidulus" Chem.Pharm.Bull.41. 654-658 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Fujimoto,M.Ikeda,K.Yamamoto and M.Yamazaki: "Structure of Fischerin,A New Toxic Metabolite from an Ascomycete,Neosartorya fischeri var.fischeri" J.Nat.Products. 56. 1268-1275 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Fujimoto,M.Nakayama,Y.Nakayama and M.Yamazaki: "Isolation and Characterization of Immunosuppressive Components of Three Mushrooms,Pisolithus tinctorius,Microporus flabelliformis and Lenzites betulina" Chem.Pharm.Bull.42. 694-697 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Haruhiro Fujimoto,Yuji Nakayama and Mikio Yamazaki: "Identification of Immunosuppressive Components of a Mushroom,Lactarius flavidulus" Chem.Pharm.Bull.41. 654-658 (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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