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PERCUTANEOUS ABSORPTION OF PEPTIDE DRUGS AND THE APPLICATION FOR MEDICAL TREATMENT

Research Project

Project/Area Number 04671380
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKINKI UNIVERSITY

Principal Investigator

OGISO Taro  KINKI UNIVERSITY, FAC PHARM.SCI., PROFESSOR, 薬学部, 教授 (60082971)

Co-Investigator(Kenkyū-buntansha) TANINO Tadatoshi  KINKI UNIVERSITY, FAC.PHARM.SCI., ASSISTANT, 薬学部, 助手 (90236703)
IWAKI Masahiro  KINKI UNIVERSITY, FAC.PHARM.SCI., LECTURER, 薬学部, 講師 (30140346)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Keywordselcatonin / ebiratide / peptide percutaneous absorption / osteoporosis / absorption enhancement / ウナギカルシトニン / 生理活性ペプチドの経皮吸収 / エルカトニンの経皮吸収 / エビラチドの経皮吸収 / 経皮吸収剤による骨粗鬆症治療
Research Abstract

1. Improvement on Percutaneous Absorption of Elcatonin
When taurocholate and D-limonen were used together as enhancers, the percutaneous absorption of elcatonin (EC) was extensively enhanced and a high bioavailability (8.7%) was obtained.
2. Effectiveness of EC Transdermal System for the Treatment of Osteoporosis
The EC transdermal system and EC plus 1,25(OH)_2D_3 system, applied to the rat abdominal skin 6 time for 48 h, significantly increased the ash weight and calcium content of the tibia in the morbid rats, compared with those of placebo group (p <0.05). Thus, the EC systems were concluded to be an efficient drug delivery system for Paget's disease and osteoporosis.
3. Percutaneous Absorption of Ebiratide
The skin penetration of [^<125>I] ebiratide from gel formulation was the greatest when EDTA, n-octyl-beta-D-thioglucoside (OTG, 1.5%) and taurocholate (1.0%) or OTG and taurocholate were used together. When the transdermal systems were applied to rat abdomen, the plasma levels of radioactivity were much higher than those after control system without enhancers. These results clearly demonstrated that ebiratide was effectively absorbed through rat skin in the persence of enhancers.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 小木曽太郎,岩城正宏,谷野公俊,朴剛: "Effectiveness of the Elcatonin Transdermal System for the Treatment of Osteoporosis and the Effect of the Combination of Elcatonin and" Biological Pharmaceutical Bulletin. 16. 895-898 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小木曽太郎,朴剛,岩城正宏,谷野公俊,西岡志穂: "Percutaneous Absorption of Physiologically Active Peptides in Rats" Biological Pharmaceutical Bulletin. (発表予定).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Taro Ogiso, Masahiro Iwaki, Tadatoshi, Tanino and Tsuyoshi Paku: "Effectiveness of the Elcatonin Transdermal System for the Treatment of Osteoporosis and the Effect of the Combination of Elcatonin and Active vitamin d_3 in Rat" Biol.Pharm.Bull.16 (9). 895-898 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小木曽太郎: "Effectiveness of the Elcatonin Transdermal System for the Treatment of Osteoporosis and the Effect" Bioloqical & Pharmaceutical Bulletin. 16. 895-898 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小木曽太郎: "Percutaneous Absorption of Physiologically Active Peptides" 17,(予定).

    • Related Report
      1993 Annual Research Report
  • [Publications] Taro Ogiso,Masahiro Iwaki,Tadatoshi Tanino: "Effectiveness of Elcatonin Transdermal System for Treatment of Osteoporosis and Effect of Combination of Elcatonin and Active Vitamine D_3" Biochemical & Pharmaceutical Bulletin. 16.

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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