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Neuropharmacological studies on sex difference in the central effects of serotonin1A agonists

Research Project

Project/Area Number 04671413
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 応用薬理学・医療系薬学
Research InstitutionOsaka University

Principal Investigator

MATSUDA Toshio  Osaka Univ. Faculty of Pharmaceutical Sciences, Associate Prof., 薬学部, 助教授 (00107103)

Co-Investigator(Kenkyū-buntansha) BABA Akemichi  Osaka Univ. Faculty of Pharmaceutical Sciences, Prof., 薬学部, 教授 (70107100)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsSerotonin / Sex difference / CRF / Corticosterone / Adenylate cyclase / カルシウムイオン / マイクロダイアリシス / アストロサイト
Research Abstract

Neuropharmacological studies on the sex differences in the effects of sserotonin _<1A> (5-HT _<1A>) receptor agonists were carried out, in order to clarify the roles of sex hormone in functional relationship between serotonergic system and CRF.
1. CRF stimulated the activity of adenylate cylase in membrane fraction of rat and mouse cerebral cortex and in homogenate of rat pituitary. There is sex difference in the stimulation. Chronic administration of 8-OH-DPAT, a typical 5-HT _<1A> agonist, did not affect CRF-stimulated adenylate cyclase activity in rat pituitary.
2. CRF stimulated tyrosine hydorxylase activity a little in rat brain synaptosomes.
3. Chronic administration of 8-OH-DPAT attenuated the increasing effect of serum corticosterone and the hypothermic effect in mice. The tolerance was observed in female mice faster than in male.
4.Forced swimming stress, which releases CRF, stimulated norepinephrine metabolism, but not 5-HT metabolsim, in hypothalamus of rats.
5.5-HT _<1A> receptor agonists did not affect interacellular Ca ^<2+> level, cAMP level and phosphoinositide metabolism in cultured rat astrocytes,
These findings suggest that the sex difference in the effect of 5-HT _<1A> receptor agonists on hypotalumus-pituitary-adrenal axis is due to that in CRF release. Futher, the sex differences in the postsynaptic effects of 5-HT _<1A> receptor agonists does not appear to be due to those in the receptor and signal transduction systems.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Yoshihide Nakano: "Sex difference for tolerance of 5-HT1A receptor-mediated temperature and corticosterone responses in mice" Eur.J.Pharmacol.219. 339-341 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takashi Yoshikawa: "Sex difference in effects of serotonin1A receptor agonists on hypothalamus-pituitary-adrenal axis" Japan.J.Pharmacol. 61SI. 277P-277P (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 吉川 崇: "新規セロンニン1A受容体作用薬MKC-242の性質" 神経化学. 32. 532-533 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshihide Nakano, Toshio Matsuda, Kazuhiro Takuma, Takashi Yoshikawa and Akemichi Baba: "Sex difference for tolerance of 5-HT _<1A> receptor-mediated gtemperature and corticasterone responses in mice" Eur. J.Pharmacol.219. 339-341 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshihide Nakano, Toshio Matsuda, Kazuhiro Takuma, Makoto Suzuki, Mitsuo Egawa, Akihiro Tobe and Akemichi Baba: "Neurochemical profile of a novel serotonin _<1A> receptor agonist, MKC-242" Bull. Japan. Neurochem. Soc.32. 532-533 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 吉川 崇: "新規セロトニンIA受容体作用薬MKC-242の性質" 神経化学. 32. 532-533 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 吉川 崇: "セロトニンIAアゴニストの視床下部-下垂体-副腎系に対する作用の性差" Japan.J.Pharmacol.61(S1). 277P-277P (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshihide Nakano,Toshio Matsuda,Kazuhiro Takuma,Takashi Yoshikawa and Akemichi Baba: "Sexdifference for tolerance of 5-HT_<1A> receptoir-mediated temperature and corticosterone responses in mice" Eur.J.Pharmacol. 219. 339-341 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takashi Yoshikawa,Toshio Matsuda,Kazuhiro Takuma,Makoto Suzuki and Akemichi Baba: "Sexdifferences in effects of seretonin_<1A> receptor agonists on hypothalamns pituitary-adrenal axis" Japan.J.Pharmacol. 61SI. 277P-277P (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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