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Study on brain functional mechanism of Ca antagonists with consideration of neuron-glia interaction.

Research Project

Project/Area Number 04671419
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 応用薬理学・医療系薬学
Research InstitutionTokyo Medical College

Principal Investigator

WATANABE Yasuo  Tokyo Medical College, School of Medicine, Associate Professor, 医学部, 助教授 (70183720)

Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
Keywordscytosolic Ca^<2+> / Ca antagonists / central acting drugs / glia cells / glutamate / neuron-glia interaction / neuronal damage / cultured cerebellar granule cells / グリアー神経細胞間相互作用 / 中枢薬理作用 / 神経-グリア細胞間相互作用 / glutamic acid / グリア細胞数定量法
Research Abstract

In order to search the significane of neuron-glia interaction on going to discuss about the central effects of Ca antagonists, the inhibitory effects of Ca antagonists on glutamate(Glu) induced-cytosolic Ca^<2+> increase and -neuronal damage were measured using by either glia-poor or glia-rich cultured cerebellar granule cells. Dosages between 0.5 and 10muM of flunarizine, nicardipine, SM6586 and SM12565 reduced the rise in [Ca^<2+>]i induced by 50mM KC1 in a dose-dependent manner, although diltiazem, verapamil and nifedipine showed less effects on such [Ca^<2+>]i increases. SM6586 and SM12565 and flunarizine at dosages below 10muM each reduced the magnitude of the [Ca^<2+>]i increase induced by 25muM Glu, but other examined Ca antagonists were less effective.
In the neuronal damage induced by Glu, the pretreatment of SM6586, SM12565 and flunarizine significantly protected. And these protections were much influenced by the co-existence of glia cells. These results suggest that the neuronal protective action of Ca antagonists have to be examined with consideration of neuron-glia interaction.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Hidenori Hayashi: "Relation between long-lasting amounts of・・・under hypoglycemia" Prog.Neuro-Psychopharmacol & Biol.Psychiat. 17. 463-474 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yasuo Yoshimura: "Inhibitory effects of calcium・・・administration of paraquat" Pharmacology & Toxicology. 72. 229-235 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Xian-Qian Zhang: "Comparative studies on the inhibitory・・・granule cells" Japan J.Pharmacol. 62. 411-414 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hidenori Hayashi et al.: "Relation between long-lasting amounts of excitatory amino acid and its neuronal uptake system in cultured cerebellar granule cells under hypoglycemia." Prog.Neuro-Psychopharmacol & Biol.Psychiat.17. 463-474 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yasuo Yoshimura et al.: "Inhibitory effects of calcium channel antagonists on motor dysfunction induced by intracerebroventricular administration of paraquat." Pharmacology & Toxicology. 72. 229-235 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Xian-Qian Zhang et al.: "Comparative studies on the inhibitory effects of calcium antagonists on cytosolic Ca^<2+> levels increased by high-potassium or glutamate in cultured rat cerebellar granule cells." Japan J.Pharmacol. 62. 411-414 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hidenori Hayashi: "Relation between long-lasting amounts of…under hypog lycemia" Prog.Neuro-Psychopharmacol & Biol.Psychiat. 17. 463-474 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yasuo Yoshimura: "Inhibitory effects of calcium channel…administration of paroguot" Pharmacology & Toxicology. 72. 229-235 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Xian-Qian Zhang: "Comparative studies on the inhibitory…Cerebellar granule cells." Japan J.Pharmacol. 62. 411-414 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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