| Project/Area Number |
04671476
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内分泌・代謝学
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| Research Institution | Osaka University |
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Principal Investigator |
KUWAJIMA Masamichi Osaka University, Internal Medicine, Assistant Professor, 医学部, 講師 (00205262)
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| Co-Investigator(Kenkyū-buntansha) |
KAWATA Sumio Osaka University, Internal Medicine, Assistant Professor, 医学部, 講師 (90183285)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | carnitine / cardiomegaly / mitochondria / long chain fatty acid / mit DNA / fatty liver / heart failure / carnitine transport activity / 総脂質 / トリアシルグリセロール / 高アンモニア血症 / 高脂血症 / 尿素サイクル |
|---|
| Research Abstract |
To evaluate the role of carnitine on lipid and carbohydrate metabolism, we analyzed the metabolic disorders in congenital systemic carnitine deficient mouse (jvs mouse). Results are as follows ;
1. In an experiment to assay the uptake of carnitine using kidney slice, homozygous mutants showed significantly lower rates of Na-dependent carnitine uptake than controls. This results indicate that the primary defect of jvs mice is most probably related to the system for reabsorption of carnitine in the kidney.
2. Jvs mice show cardiac hypertrophy which is caused by enlargement of the cardiac muscle cell associated with enlargement of mitochondria. Carnitine administration significantly suppresses the cardiac hypertrophy. These results show that carnitine deficiency plays an important role in the development of the cardiac hypertrophy.
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