| Project/Area Number |
04671531
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
MAEKAWA Taira KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 講師 (80229286)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Akira KYOTO INSTITUTE OF TECHNOLOGY PROFESSOR, 繊維学部, 教授 (60210001)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1992: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | ANTISENSE / LEUKEMIA / MOLECULARLY TARGETTED THERAPY / 遺伝子治療 |
|---|
| Research Abstract |
1. Establishment of large-scale synthesizing and purification methods for antisense oligonucleosides phosphorothioates (1993)
2. Evaluation of cell-membrane permeability of antisense oligonucleotides (1993)
3. Examination of non-specific toxic effects on hematopoietic progenitors by antisense oligonucleotides (1993)
4. Confirmation of clonal suppression on hemopoietic progenitor growth of chronic myeloid leukemia cells by BCR-ABL antisense oligonucleotides(1993, 1994)
5. Evaluation of sequence specificity of BCR-ABL antisense oligonucleoside phosphorothioates on growth suppression of chronic myeloid leukemia cells (1994)
6. BCR-ABL antisense oligonucleotides caused apoptotic cell death of chronic myeloid leukemia cells BV173, and confirmation of reduced production of p210 chimeric protein by these antisense oligomers (1994)
7.Effects of BCR-ABL antisense oligonucleotides on the survival of BV173 leukemic cell transplanted mice are now under investigation (1994)
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