| Project/Area Number |
04680110
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
体育学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ITO Akira University of Tsukuba, Institute of Health and Sport Sciences, Prof., 体育科学系, 教授 (80056639)
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| Co-Investigator(Kenkyū-buntansha) |
MIKAMI Toshio Nippon Medical School, Medical Department, Instructor, 第二生化学, 講師 (60199966)
TAZAKI Yousuke University of Tsukuba, Institute of Health and Sport Sciences, Assistant Prof., 体育科学系, 助教授 (30114101)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Purine metabolism in liver / hadaidin / AMP deamination / IMP reamination / 筋中プリン代謝 / hadacidin / AMPdeamination / IMPreamination / ^<15>N / プリン代謝 / 尿酸 / アデニンヌクレオチド |
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| Research Abstract |
The purpose of this study was to investigate purine metabolism in liver after exercise. The plan of this study was to give ^<15>N-labeled adenine to rats before exhaustive running exercise and then to assay purine metabolism in liver and to trace ^<15>N contents in liver and urinary uric acid after exercise.
A resting control group did not exercise with ^<15>N-labeled adenine.
The results were as follows.
1) ^<15>N contents in liver was significantly decreased under any times.
2) ATP and Total adenine nucleotide(ATP + ADP + AMP) was significantly decreased at 0 min.no significant changes in IMP was observed under any times.
3) ^<15>N contents in urinary uric acid was significantly increased.
These results suggest that adenine nucleotide degradation and uric acid production were increased in liver during exercise.
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