| Project/Area Number |
04807022
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Niigata University |
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Principal Investigator |
IWAFUCHI Mitsuya Niigata University, College of Biomedical Technology, Department of Medical Tecnology, Professor(Pathology), 医療技術短期大学部, 教授 (70143766)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Hidenobu Niigata University, School of Medicine, Department of Pathology, Professor(Patho, 医学部, 教授 (70037381)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Carcinoid / Endocrine cell carcinoma / APUDoma / Paraneuroma / Gut hormone / Cell culture / 消化管 / 内分泌細胞腫瘍 / 分子病理 / カルテノイド腫瘍 / 内分泌細胞 / PCNA / P53 / K-ras |
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| Research Abstract |
During the period of past two years of this particular project, endocrine cell tumors of the gastrointestinal tract of Japanese were collected and analyzed.
1. Endocrine cell tumors of the gastrointestinal tract were divided into two groups : carcinoid tumor(CD), low-grade malignacy and endocrine cell carcinoma(ECC). high-grade malignancy. Histological differential diagnosis between these two entities wasestablished.
2. CD was suspected to be mainly derived from immature endocrine cells. ECC were hypothesized to derive from neoplastic endcrine cell in mucosal tubular adenocarcinoma, totipotential stem cell, CD, or immature endocrine cells. The first pathway was suspected to be most frequent, followed by the second.
3. New classification of carcinoid tumors according to different ocurring sites wasestablished. Japanese patients have characteristic and incidence of distribution different from that of Europeans and Americans.
4. Four cell lines were established from human esophageal, gastric and rectal ECC.They showed high levels of CK-BB (4 lines), low levels of aromatic L-amino-acid decarboxylase(2 lines) and NSE (3 lines), no amplification of C-myc, N-myc and L-myc (4lines) and expression of c-myc mRNA (2 lines).
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