| Project/Area Number |
04807086
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | KYORIN UNIV.SCH. |
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Principal Investigator |
YUKIOKA Tetuo Kyorin Univ.Sch.of Med.Assistant Professor, 医学部, 助教授 (00182668)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Shin Kyorin Univ.Sch.of Med.Assistant, 医学部, 助手
YUKIOKA Tetuo Kyorin Univ.Sch.of Med.Assistant Professor, 医学部, 助教授 (00182668)
SHIMAZAKI Shuji Kyorin Univ.Sch.of Med.Professor, 医学部, 教授 (90028689)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Hypoxia / Acute Respiratory Failure / Oxygen Consumption / Oxygen Delivery / Core Temperature / Induced Hypothermia / Optimum Core Temperature / 心機能障害 / 低体温 / 呼気分析による間接的熱量測定 |
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| Research Abstract |
Hypothermia is one of therapeutic options in patients with severe acute respiratory failure. This study was designed to determine the optimum core temperature during hypoxemia by analyzing oxygen delivery (DO_2) and consumption (VO_2). Six dogs were ventilated using a mixed gas of N_2 and air (F_IO_2=0.12) with total muscle relaxation under general anesthesia. Hypoxia (PaO_2 around 35 mmHg) was maintained during the experimental period. The core temperature was reduced progressively from 37ﾟC to 30ﾟC by surface cooling. DO_2 divided by VO_2 was defined as the coefficient of oxygen delivery. In each animal, the coefficient of oxygen delivery was calculated by altering the core temperature by 1ﾟC.The relative value of the coefficient of oxygen delivery in each animal was a third-order polynomial function of core temperature having a maximum value at a core temperature of 32.1 <plus-minus> 0.46ﾟC.At a core temperature of 32ﾟC,the blood lactate level was significantly lower than that at a core temperature of 37ﾟC (6.3 <plus-minus> 1.3mg/dl versus 12.2 <plus-minus> 1.6mg/dl, p<0.05). The relative value of the coefficient of oxygen delivery was highest with limited lactate elevation at a core temperature around 32ﾟC.Under the condition of hypoxia, mild hypothermia around 32ﾟC may be optimal to improve oxygen demand-supply balance.
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