New gallstone solvent with dissolving action for mucin in the gallstone.
| Project/Area Number |
04807089
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
ISE Hideo School of medicine, Tohoku University assistant professor, 医学部, 講師 (10150260)
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| Co-Investigator(Kenkyū-buntansha) |
MORIYASU Akihito University medical center assistant professor, 医学部・附属病院, 助手 (10241621)
KITAYAMA Osamu University medical center assistant professor, 医学部・附属病院, 助手 (80214823)
臼井 律郎 東北大学, 医学部・附属病院, 助手
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Gallstone / mucin / Acetylcystein / 胆石溶解剤 / 胆石中ムチン / 胆石切片標本 / 酸性ムチン |
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| Research Abstract |
We performed the analysis of the composition of gallstones, and obtained the results that ; (1)there were the nucine-network structures into the gallstones, which carried out the Constructive role of the gallstone, (2)nucin into the gallstones were the sulfated glyeoprotein as a acidic nucin.
In this result, we tried to dissolve the gallstone nucin by ascetylcystein as a nucous solvent.
Acetylcystein disintegrated theall Rind of gallstones in vitro prompthy.
Acelytystein was acidic substunce and neutrized by NaltCO_3 in use.
Disintegrating action of acetylcystein was best under the Condition of pH 7.5-8.0. We examined the toxicity of acetylystein injecting into the bete duct. Gcute and chronic toxicity was not observed in histochemicaly and blood demically.
Conculusion, we think the acetylcystein is a gallstone solvent, by mechanism of the dissolved nucin network in the gallstone.
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Report
(4 results)
Research Products
(7 results)
