| Project/Area Number |
04807097
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MITSUI Toshio University of Tsukuba, Dept.of Surgery, Professor, 臨床医学系, 教授 (60010170)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Long QT syndrome / signal-averaged ECG / inhomogeneity of sympathetic nerve system / ventricular tachycardia / autonomic agent / RMST / QRSD / beta-adrenergic receptor / 自立神経薬 / 星状神経節 / 交感神経支配不均衡 / 上室性頻拍 / RMS_<40> / 星状神経節ブロック / 交感神経緊張不均衡 / 難治性不整脈 / 局所的興奮性 / 房室伝導時間 / QRS持続時間 |
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| Research Abstract |
It is known that congenital hypofunction of right-sided sympathetic activity is one of the main cause of Long QT Syndrome (LQTS). As the result of this malfunction, left-sided sympathetic activity through left stellate ganglion become relatively larger than normal condition. High frequency component of QRS complex is also affected by catecholamine. Especially, stimulation of beta-adrenergic receptor induces the decrement of high frequency component through the suppression of Na^+ fast channel depolarization and prolongs the QRS duration for that reason. In this study, prolonged QRS duration in high frequency bands was found in both stimulation of left stellate ganglion by electrical spike and injection of isoproterenol. From those results, detection of high frequency component of QRS complex may be useful method for both recognition of LQTS and effectiveness of treatment after surgical resection of left stellate ganglion in patients with LQTS.
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