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Pathophysiological investigation by MRSI of dimentia due to brain vascular disorders and aging

Research Project

Project/Area Number 04836006
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 老化(加齢)
Research InstitutionToyama Medical and Pharmaceutical University

Principal Investigator

NISHIJO Hisao  Toyama Medical and Pharmaceutical University, Department of Physiology, Associate Professor, 医学部, 助教授 (00189284)

Co-Investigator(Kenkyū-buntansha) UWANO Teruko  Toyama Medical and Pharmaceutical University, Department of Physiology, Assistan, 医学部, 助手 (80242486)
FUKUDA Masaji  Toyama Medical and Pharmaceutical University, Department of Behavioral Sciences,, 医学部, 教授 (60126547)
ONO Taketoshi  Toyama Medical and Pharmaceutical University, Department of Physiology, Professo, 医学部, 教授 (50019577)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsIschemia / Dementia / Calcium Blocker / Ischemic Cell Changes / Primate / Hippocampal Formation / Functional MRI / 機能的MRI / 慢性脳虚血 / MRSI
Research Abstract

Mechanisms and pharmacological therapy of memory disorders due to hippocampal(HF)lesions were investigated. First, techniques to produce ischemic neuronal death confined to CA1 subfield of the HF in monkeys was developed. Ischemia for 10 to 15 min by occluding 8 vessels(the bilateral vertebral, common, internal and external carotid arteries)produced cell death limited to the deeper portion of the pyramidal cell layr of the CA1 subfield in the HF.Treatment with (+)-1-(3, 4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl) ethanol dihydrochloride (NC-1100, Nippon Chemiphar Co., Ltd)markedly reduced both ischemic neuronal damage in the CA1 subfield of the HF and memory disorder. It is suggested that post-ischemic treatment with the calcium entry blocker, NC-1100, might protect the brain from the ischemic damage that is produced in patients suffering from trransient ischemia.
Second, rats were also subjected to 15 min brain ischemia to produce same HF lesions as in monkeys. In a spatial navigation task in which rats were required to memorize specific areas in the field, the acquisition performance of ischemic-rats was significantly inferior to that of control-rats. Repeated administrations of (-)R-1-(Benzo[b]thiophen-5-yl)-2-[2(N, N-diethylamino)ehoxy]ethanol hydrochloride (T-588, Toyama Cheminal Co.Ltd.)siginificantly ameliorate impaired performance of ischemic-rats in a spatial navigation task, without causing any behavioral abnormalities. The intracellular recording from HF pyramidal cells indicated that T-588 has a direct excitatory effects on hippocampal CA1 pyramidal cells. The functional MRI detected increment in signal intensity, which reflects increment in blood flow, in various brain areas such as HF, parietal cortex, amygdala, and striatum. T-588 may be, at least in part, attributable to its ability to improve the cognitive dysfunction in patients with senile dementia or other organic brain syndrome.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (53 results)

All Other

All Publications (53 results)

  • [Publications] Tamura R.: "Monkey hippocampal neuron responses to complex sensory stimulation during object discrimination." Hippocampus. 2. 287-306 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H.: "Calcium entry blocker ameliorates ischemic neuronal damage in monkey hippocampus." Brain Res.Bull.29. 519-524 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tabuchi E.: "Hippocampal neuronal damage after transient forebrain ischemia in monkeys." Brain Res.Bull.29. 685-690 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H.: "Food memory:neuronal involvement in food recognition." Asia Pacific J.Clin.Nutr.1. 3-12 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Muramoto K.: "Rat amygdaloid neuron responses during auditory discrimination." Neurosci.52. 621-636 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukuda M.: "Neuronal responses in monkey anterior putamen during operant bar-press behavior." Brain Res.Bull.32. 227-233 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ono T.: "Monkey hippocampal neuron responses related to spatial and non-spatial influence." Neurosci.Lett.159. 75-78 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ono T.: "Monkey hippocampal neurons related to spatial and nonspatial functions." J.Neurophysiol.70. 1516-1529 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H.: "Rat amygdalar neuronal responses to gustatory and multimodal stimulation." Proc.of 26th Jpn.Symp.Taste & Smell. 26. 101-104 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H.: "Localization of dipole by boundary element method in three dimensional reconstructed monkey brain." Brain Res.Bull.33. 225-230 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hayashi N.: "Dipole tracing of monkey somatosensory evoked potentials." Brain Res.Bull.33. 231-235 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H.: "Amygdalar neuronal responses to taste and other sensory stimuli in awake rats." Olfaction and Taste XI,Springer-Verlarg. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 西条寿夫: "ラット扁桃体ニューロンの摂食行動への応答性." 肥満. 12. 97-99 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 林央周: "中心溝近傍脳腫瘍の術前局在診断における双極子追跡法の有用性." CI研究. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 西条寿夫: "大脳辺縁系は記憶の貯蔵庫か?" 遺伝. 47. 44-53 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小野武年: "海馬体の認知・記憶関連ニューロン." 神経研究の進歩. 38. 126-139 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 西条寿夫: "海馬破壊による実験的記憶障害." 神経研究の進歩. 38. 112-125 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ono T.: "Neurophysiological basis of the Kluver-Bucy syndrome:Responses of monkey amygdaloid neurons to biologically significant objects,In The Amygdala:Neurobiological Aspects of Emotion,Memory,and Mental Dysfunction,by Aggleton J.(Ed.)167-190,1992." John Wiley & Sons,New York, 167-190 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ono T.: "Neural Mechanisms of recognition and memory in the limbic system,In Brain Mechanisms of Perception and Memory:From Neuron to Behavior,by Ono T.,Squire L.R.,Raichle M.E.,Perrett D.I.,Fukuda M.(Eds.)" Oxford University Press,New York, 339-357 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H.: "Amygdalar and hippocampal neuron responses related to recognition and memory in monkey,In Progress in Brain Research,by Hicks T.P.,Molotchnikoff S.,and Ono T.(Eds.)Vol.95" Elsevier,Amsterdam, 339-357 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 西条寿夫: "サルの記憶システム.「老化と脳」大村裕,大浦彦吉編" 共立出版, 260-270 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小野武年: "サルの中隔-海馬体系における認知・記憶機能.ブレインサイエンス研究報告集5:40-55,1992." ブレインサイエンス振興財団, 40-55 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小野武年: "認知機能の分子生物学.「分子神経科学の最前線」岡田善雄監修,遠山正彌,塩坂貞夫編" 厚生社(印刷中),

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小野武年: "記憶における海馬体の役割.「脳とニューラルネット-高次機能の解明へ向けて」甘利俊一,酒田英夫編" 朝倉書店(印刷中),

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 西条寿夫: "学習と記憶.新医科学大系第10巻脳と行動" 中山書店(印刷中),

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tamura R., Ono T., Fukuda M., and Nishijo H.: "Monkey hippocampal neuron responses to complex sensory stimulation during object discrimination." Hippocampus. 2. 287-306 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H., Kuze S., Ono T., Tabuchi E., Endo S., and Kogure K.: "Calcium entry blocker ameliorates ischemic neuronal damage in monkey hippocampus." Brain Res.Bull.29. 519-524 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tabuchi E., Endo S., Ono T., Nishijo H., Kuze S., and Kogure K.: "Hippocampal neuronal damage after transient forebrain ischemia in monkeys." Brain Res.Bull.29. 685-690 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H.and Ono T.: "Food memory : neuronal involvement in food recognition." Asia Pacific J.Clin.Nutr. 1. 3-12 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Muramoto K., Ono T., Nishijo H., and Fukuda M.: "Rat amygdaloid neuron responses during auditory discrimination." Neurosci.52. 621-636 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukuda M., Ono T., Nishijo H., and Tabuchi E.: "Neuronal responses in monkey anterior putamen during operant bar-press behavior." Brain Res.Bull.32. 227-233 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ono T., Eifuku S., Nakamura K., and Nishijo H.: "Monkey hippocampal neuron responses related to spatial and non-spatial influence." Neurosci.Lett.159. 75-78 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ono T., Nakamura K., Nishijo H., and Eifuku S.: "Monkey hippocampal neurons related to spatial and non-spatial functions." J.Neurophysiol.70. 1516-1529 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H., Uwano T., Fukuda M., Yonemori M., and Ono T.: "Rat amygdalar neuronal responses to gustatory and multimodal stimulation." Proc.of 26th Jpn.Symp.Taste & Smell. 101-104 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H., Hayashi N., Fukuda M., Endo S., Musha T., and Ono T.: "Localization of dipole by boundary element method in three dimensional reconstructed monkey brain." Brain Res.Bull.33. 225-230 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hayashi N., Nishijo H., Endo S., Fukuda M., Homma S., and Ono T.: "Dipole tracing of monkey somatosensory evoked potentials." Brain Res.Bull.33. 231-235 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H., Uwano T., Yonemori M., and Ono T.: "Amygdalar neuronal responses to taste and other sensory stimuli in awake rats." Olfaction and Taste XI, Springer-Verlarg. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nishijo H.: "Localization of dipole by boundary element method in three dimensional reconstructed monkey brain." Brain Res.Bull.33. 225-230 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hayashi N.: "Dipole tracing of monkey somatosensory evoked potentials." Brain Res.Bull.33. 231-235 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nishijo H.: "Amygdalar neuronal responses to taste and other sensory stimuli in awake rats." Olfaction and Taste XI,Springer-Verlarg. (in press.).

    • Related Report
      1993 Annual Research Report
  • [Publications] 西条寿夫: "大脳辺縁系は記憶の貯蔵庫か?" 遺伝. 47. 44-53 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小野武年: "海馬体の認知・記憶関連ニューロン." 神経研究の進歩. 38. 126-139 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 西条寿夫: "海馬破壊による実験的記憶障害" 神経研究の進歩. 38. 112-125 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小野武年: 朝倉書店(印刷中),

    • Related Report
      1993 Annual Research Report
  • [Publications] 西条寿夫: "学習と記憶.新医科学大系 第10巻 脳と行動" 中山書店(印刷中),

    • Related Report
      1993 Annual Research Report
  • [Publications] Nishijo,H.: "Calcium entry blocker ameliorates ischemic neuronal damage in monkey hippocampus." Brain Research Bulletin. 29. 519-524 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nishijo,H.: "Food memory:neuronal involvement in food recognition." Asia Pacific J.Clin.Nutrition. 1. 3-12 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nishijo,H.: "Amygdalar and hippocampal neuron responses related to recognition and memory in monkey." Progress in Brain Research,in press.

    • Related Report
      1992 Annual Research Report
  • [Publications] Tabuchi,E.: "Hippocampal neuronal damage after transient forebrain ischemia in monkeys." Brain Research Bulletin. 29. 685-690 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tamura,R.: "Monkey hippocampal neuron responses to complex sensory stimulation during object discrimination." Hippocampus. 2. 287-306 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Muramoto,K.: "Rat amygdaloid neuron responses during auditory discrimination" Neuroscience. 52. 621-636 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ono,T.: "Neurophysiological basis of the kluver-Bucy syndrome:Responses of monkey amygdaloid neurons to biologically significant objects.In:The Amygdala,by J.Aggleton(Ed.)" John Wiley & Sons,New York, 167-190 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 西条 寿夫: "15.サルの記憶システム 老化と脳,大村 裕,大浦 彦吉 編集" 共立出版, 260-270 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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