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Mass spectrometric analysis of crosslinker of aging proteins formed by Maillard reaction

Research Project

Project/Area Number 04836009
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 老化(加齢)
Research InstitutionNagoya University

Principal Investigator

NIWA Toshimitsu  Nagoya University, School of Medicine, Associate Professor, 医学部, 助教授 (20208268)

Co-Investigator(Kenkyū-buntansha) NIWA Toshimitsu  Nagoya University, School of Medicine, Associate Professor (20208268)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsMaillard reaction / 3-deoxyglucosone / gas chromatography / mass spectrometry / diabetes mellitus / diabetic nephropathy / タンパク質 / 架橋重合 / グルコース / 質量分析法 / 電気泳動 / HPLC
Research Abstract

3-Deoxyglucosone, a potent protein crosslinking intermediate of the Maillard reaction, was first detected in diabetic serum using gas chromatography/mass spectrometry. Serum concentration of 3-deoxyglucosone was elevated in diabetic patients as compared with healthy subjects. More notably, diabetic patients with nephropathy showed higher serum concentration of 3-deoxyglucosone than those without nephropathy. The increased serum concentration of 3-deoxyglucosone in the diabetic patients suggests that 3-deoxyglucosone may be responsible for the development of diabetic comlications such as diabetic nephropathy by promoting the formation of advanced glycation end products.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Toshimitsu NIWA: "Presence of 3-deoxyglucosone,a potent protein crosslinking intermediate of Maillard Reaction,in diabetic serum." Biochem Biophys Res Commun. 196. 837-843 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Niwa, T., Takeda, N., Yoshizumi, H., Tatematsu, A., Ohara, M., Tomiyama, S., Niimura, K.: "Presence of 3-deoxyglucosone, a potent protein crosslinking intermediate of Maillard Reaction, in diabetic serum" Biochem. Biophys. Res. Commun. 196. 837-843 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Toshimitsu NIWA: "Presence of 3-deoxyglucosone,a potent protein crosslinking intermediate of Maillard Reaction,in diabetic serum." Biochem Biophys Res Commun. 196. 837-843 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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