Mass spectrometric analysis of crosslinker of aging proteins formed by Maillard reaction
| Project/Area Number |
04836009
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
老化(加齢)
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| Research Institution | Nagoya University |
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Principal Investigator |
NIWA Toshimitsu Nagoya University, School of Medicine, Associate Professor, 医学部, 助教授 (20208268)
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| Co-Investigator(Kenkyū-buntansha) |
NIWA Toshimitsu Nagoya University, School of Medicine, Associate Professor (20208268)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Maillard reaction / 3-deoxyglucosone / gas chromatography / mass spectrometry / diabetes mellitus / diabetic nephropathy / タンパク質 / 架橋重合 / グルコース / 質量分析法 / 電気泳動 / HPLC |
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| Research Abstract |
3-Deoxyglucosone, a potent protein crosslinking intermediate of the Maillard reaction, was first detected in diabetic serum using gas chromatography/mass spectrometry. Serum concentration of 3-deoxyglucosone was elevated in diabetic patients as compared with healthy subjects. More notably, diabetic patients with nephropathy showed higher serum concentration of 3-deoxyglucosone than those without nephropathy. The increased serum concentration of 3-deoxyglucosone in the diabetic patients suggests that 3-deoxyglucosone may be responsible for the development of diabetic comlications such as diabetic nephropathy by promoting the formation of advanced glycation end products.
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Report
(3 results)
Research Products
(3 results)
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[Publications] Niwa, T., Takeda, N., Yoshizumi, H., Tatematsu, A., Ohara, M., Tomiyama, S., Niimura, K.: "Presence of 3-deoxyglucosone, a potent protein crosslinking intermediate of Maillard Reaction, in diabetic serum" Biochem. Biophys. Res. Commun. 196. 837-843 (1993)
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