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AGE ASSOCIATED CHANGE OF ENDOCRINE SYSTEM AND LONGEVITY OF THE NEWLY DISCOVERED INHERITED GROWTH RETARDED MOUSE

Research Project

Project/Area Number 04836010
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 老化(加齢)
Research InstitutionMIE UNIVERSITY

Principal Investigator

YOSHIDA Takeshi  MIE UNIVERSITY,FACULTY OF MEDICINE,LECTURER, 医学部, 講師 (90106972)

Co-Investigator(Kenkyū-buntansha) SOYA Hideaki  MIE UNIVERSITY,FACULTY OF EDUCATION,ASSOCIATE PROFESSOR, 教育学部, 助教授 (50221346)
TSUMURA Hideki  MIE UNIVERSITY,FACULTY OF ASSISTANT, 医学部, 助手 (20180052)
渥美 伸一郎  三重大学, 医学部, 助手 (60192978)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsGROWTH RETARDED MOUSE / HYPOTHYROID / GROWTH HORMONE / PROLACTIN / LONGEVITY / PITUITARY ENLARGEMENT / AGE ASSOCIATED CHANGE / THYROTROPHS / 甲状腺機能低下症 / 加齢変化 / 脳下垂体 / 甲状腺刺激ホルモン / 成長遅延 / 脳下垂体前葉 / 色素嫌性細胞 / 形質転換(トランスフォーメーション) / オルニチン脱炭酸酵素 / 加齢 / 甲状腺ホルモン / プロラクチン / マウス
Research Abstract

In this study, as in the followings, we determined the characteristics and the age associated change of the endocrine system of the mutant strain of mouse, the "growth retarded" (gr) mouse, which was newly derived from DW/J strain mouse with special attention to the pituitary-thyroid axis and other anterior pituitary hormones.
1) gr mice suffer a severe deficiency in thyroid hormone from neonate due to primary hypothyroidism as in the human cretinism. The character inherits in an autosomal recessive manner and the gene responsible was named as grt.
2) The serum concentration of thyroxine in gr mice slightly increases after three months of age but remains subnormal through their lives.
3) The lack of thyroid hormones results in the extraordinary stimulation of both hormone synthesis and secretion, and finally exhaustion, in the thyrotrophs of gr mice and, on the other hand, in the delayd proliferation and/or maturation of somatotrophs and lactotrophs. The pituitary contents of growth hormo … More ne and prolactin in gr mice increased at a same extent of delay as the growth retardation compared to normal mice and remained subnormal until old ages.
In order to see the effects of such as endocrine status of gr mice on the life span of mice, we attempted to determine the longevity of gr mice under a SPF (specific pathogen free) condition and compare with that of normal mice. The study is still in progress and, however, the days of 50 % survival calculated for a group of 7 male gr mice and a group of 14 normal counterparts with similar birth dates were found to be about 600 and 700 days, respectively. As previously reported, the pituitary glands of gr mice enlarge with age and, in most of the gr mice examined at death, the pituitary glands enlarged so much that they looked as if tumors.
Taking into consideration of these facts, the results of present study indicate that thyroid hormones and growth hormone are essential for the growth and maturation of mice but not for the maintenance of life of adult mice, at least, under a comfortable condition. The analyzes of the age associated changes of certain physiological functions, such as energy metabolism, that should serve a suitable measure of ageing process in gr mice remain as interesting future subjects. Less

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 吉田 豪: "成長遅延症マウスの下垂体プロラクチン含量の加齢変化" 第8回下垂体研究会学術集会予稿集. 3 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshida,T.: "The thyroid gland of the novel "growth retarded" mouse does not respond to TSH" Abstracts for XXX11 Congress of the International Union of Physiological Sciences 1993. 2135-P (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hibasami,H.: "Expression of high activity of ornithine decarboxy-Ease and occurrence of unusual chromcphobic cells in interior pituitary gland of a novel(grewth retarcked strain of mice,grewgron" Biochim.Biophys.Acta. 1226. 110-114 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshida, T.: "A novel hypothyvoid "growth retarded" mouse derived from Smell's dwant mouse" J. Endocr.142. 435-446 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshida T.: "A novel "growth retarded" mouse may be a useful model for the study of the mutuae interactions between pituitary and thyroidgland in growth and development" Abstracts for the 10th Asia-Oceania Congress of Endocrinology. 277 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tomita,K.: "In viro responsiveness of thyroidglands to TSH in normal and novel “growth-retarded" mice :transient elevation in normal mice and impairment in growth-retouded mice" J. Endocr.144. 209-214 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshida T., Yamanaka K., Atsumi S., Tsumura H., Sasaki R., Tomita K., Ishikawa E., Ozawa H., Watanabe K.and Totsuka T.: "A novel hypothyroid 'growth retarded' mouse derived from Snell's dwarf mouse." J.Endocr.142. 435-446 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tomita K., Yoshida T., Morita J., Atsumi S.and Totsuka T.: "In vivo responsiveness of thyroid glands to TSH in normal and novel grouwth-retarded'mice : transient elevation in normal mice and impairment in 'growth-retarded' mice." J.Endocr.144. 209-214 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hibasami H., YoshidaT., Totsuka T., Atsumi S.and Nakashima K.: "Expression of high activity of ornithine decarboxylase and occurrence of unusal chromophobic cells in anterior pituitary gland of a novel growth retarded strain of mice, grmlgrm." B.B.A. 1226. 110-114 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshida T., Tomita, K., Atsumi, S., Tsumura, H., and Totsuka, T.: "The Thyroid galnd fo the novel "growth retarded" mouse does not respond to TSH." Abstracts for XXXII Cougress of the International Union of Pnysiological Sciences. 213-251 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshida T., Hibasami, H., Tsumura H., Atsumi S., Totsuka, T.and Nakashima, K.: "A novel "growth relarted" mouse may be a useful model for the study of the mutual intcractions between pituitary and thyroid gland in growth and development." Abstracts for 10th Asia-Oceania Congress of Endocrinology. 277 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshida T., Tomita K., Ishikawa, E., Ishinaga H., Atsumi, S.and Totsuka, T.: "Age associated change of the functions of pituito-thyroidal axis in mice." Jpn.J.Physiol. 43.SUPPL 2.S298. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hibasami,H.: "Expression of high activity of ornithine decarboxylase and occurence of unusual chromophobic cells in anterior pituitary gland of novel growth" Biochim Biophys.Acta. 1226. 110-114 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 吉田豪: "甲状腺ホルモン投与は成長遅延症マウス下垂体前葉における異常な色素嫌性細胞の発現を抑制する" 下垂体研究会学術集会予稿集. 9. 11- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshida T.: "A novel hypothyroid growth retarded'mouse derived from Snell's dwarf mouse" J.Endocr.142. 435-446 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshida,T.: "A novel "growth retarded" mousemay be a useful model for the study ofthe mutual interactions between pituitary and・・・・." Abstracts for the 10th Asia-Oceania Congress of Endo crinology. 277- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshida,T.: "High activity of ornithine decarboxylase in anterior pituitary gland of "growth retarded" mouse" Jpn.J.Physiol.Suppl.44. 5266- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tomita,K.: "In vivo responsiveness of thyroid glands to TSH in normal and novel 'growth-retarded'mice:transient elevation in normal-・・・" J.Endocr.144. 209-214 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Hibasami,T.Yoshida et al.: "Expression of high activity of ornithine decarboxylase and occurrence of unusual chromophobic cells in anterior pituitary gland of a growth retarded strain of mice,grm/grm." Biochem.Biophys.Acta. (in press).

    • Related Report
      1993 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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