Multiple alpha-globin genes of crab-eating monkey : Resistance to malarial infection
| Project/Area Number |
05041089
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Field Research |
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| Research Institution | Primate Research Institute, Kyoto University |
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Principal Investigator |
TAKENAKA Osamu Professor, Primate Research Institute, Kyoto Univ., 霊長類研究所, 教授 (00093261)
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| Co-Investigator(Kenkyū-buntansha) |
バラブディ P. チュラロンコン大学, 理学部, 教授
SUZUKI Juri Instructor, Primate Research Institute, Kyoto Univ., 霊長類研究所, 助手 (10175408)
VARAVUDHI Puttipongse Professor, Faculty of Science, Chulalongkorn Univ.
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| Project Period (FY) |
1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1993: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Crab-eating monkey / Macaque / Gene / alpha-globin gene / Malaria-resistant / Morphology / Development / Adaptation |
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| Research Abstract |
Livinig organisms show a variety of adaptation to natural environment through evolution, that changed in nucleotides in their genes. For example, animals living in highland or underground have hemoglobins of high oxygen affinity. Regional disease is also an environmental factor for natural animals. We found that the crab-eating macaques of Malayan penninsula and Sumatra have multiplied alpha-globin genes in high frequency and those monkeys have high hematological values. The present study was undertaken to access the hypothesis that crab-eating monkeys can adapt themselves against malarial infection by gene duplication.
We performed capture-and-release field works of crab-eating macaques in several localities in Thailand. Under anesthetization, morphological data and blood specimens were collected. Thick and thin blood smear was also prepared for microscopic observation of malarial infection. Hemato logical values were measured near from the field and buffy coat was brought back to Japan. The number of alpha-globin gene will be determined by Southern blot analysis.
In the field work, the morphological data were also collected. By combining with the previous data, the crab-eating monkeys in Thailand have big body size and heavy body weight as compared with those of Malaysia, Indonesia and the Philippines. In Thailand, crab-eating monkeys of Songklah, southern part were the biggest followed by those of northeastern part. The smallest was Yala, again, southern part. This results contrasted with the clinal trait of genetic data.
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Report
(1 results)
Research Products
(2 results)
