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Medical Scientific Research on Highlanders in Himalayas

Research Project

Project/Area Number 05041107
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionField Research
Research InstitutionChiba University

Principal Investigator

KURIYAMA Takayuki  School of Medicine. Chiba University Professor, 医学部, 教授 (20009723)

Co-Investigator(Kenkyū-buntansha) 肖 和平  チベット結核対策センター, 所長
SHRESTA G.P.  トリバン大学, 医学部, 教授
HAYANO Masashi  School of Medicine. Chiba University Lecturer, 医学部, 助手 (10272329)
ONOZAKI Ikushi  Anti-Tuberculosis Association, 研究員
KOBAYASHI Toshio  Tokyo University of Mercantile Marine Sub-Professor, 助教授 (20251069)
KIMURA Hiroshi  School of Medicine. Chiba University Sub-Professor, 医学部, 講師 (20195374)
TANAKA Michiko  Jyunshin Women College Sub-Professor, 講師 (30249700)
MASUDA Atsuko  School of Medicine. Chiba University Sub-Professor, 医学部, 助手 (70165710)
MASUYAMA Shigeru  School of Medicine. Chiba University Lecture, 医学部, 助手 (00219354)
FUKUDA Yasuichirou  School of Medicine. Chiba University Professor, 医学部, 教授 (10009649)
KOHNO Toshihiko  Kokusai Budo University Professor, 教授 (50092052)
SAKAKIBARA Yoshikazu  Kanazawa Institute Technology Professor, 教授 (50092060)
NOGAWA Kouji  School of Medicine. Chiba University Professor, 医学部, 教授 (40019584)
MIKATA Atsuo  School of Medicine. Chiba University Professor, 医学部, 教授 (40051289)
G.P Shresta  Tribuban University Hospital Professor
XIAO He-Ping  Tibet Tuberculosis Control Center Director
ACHARYA G.P  トリバン大学, 医学部, 教授
巽 浩一郎  千葉大学, 医学部, 助手 (10207061)
本田 良行  千葉大学, 医学部, 名誉教授 (30019525)
ACHARYA G.P.  トリバン大学, 医学部, 教授
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 1995: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1994: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1993: ¥5,000,000 (Direct Cost: ¥5,000,000)
KeywordsHypoxia / High Altitude / Adaptation / Tuberculosis / Hodgkin Disease / EB virus / Gastric cancer / Lymphoma / Helicobacter pylori / Highlander / Tuberculosis / Mountain Sickness / Carotid body / Carotid Body / Respiratory Control / Living Environment
Research Abstract

1. Respirato-physiological study in Nepal Himalayan. Study of altitude acclimatization mechanism of respiratory control was carried out in Nepal Khumbu area. Resting ventilation and SpO2s during breath holding test from end-expiratory lung volume and effect of oxygen on these parameters were studied at 1300m, 2827m, 3440m and 4430m. Analysis of relationships between these parameters and hypoxic ventilaotry response revealed that even after acclimatizing period increased hypoxic chemosensitivity was accompanied by hypoxic ventilatory depression which was markedly detected in acute hypobaric hypoxia study at sea level.
2. Pathological study on EB virus related tumors in Nepal. Regional differences have been reported in a histological type of Hodgkin disease (HD) and frequency of EB virus related HD.24 cases of lymphoma and 54 cases of gastric cancer speciemens of the pathological department of Tribuban University Hospital and CMN Patan Hospital in Katmandu were studied immunologically and pathologically. 7 out of 8 HD and 1 out of 16 non-Hodgkin lymphoma cases revealed LMP-1 and EBER-1 ISH positive. In case of gastric cancer, only one out of 54 cases was a positive. Helicobacter Pylori infection was identified in 14 cases out of 38 low differentiated type and one case out of 2 mucous type. No case was positive in 13 high and intermediate differentiated types.
3. Histological study on high-altitude animals. Histological study on alveolar structure of Yak (Bos grunnieens) grown up in Nepal Himalayan region and Tibetan plateau was performed. Optical microscopic study showed that the Yak have wider alveolar space and thinner alveolar wall, though elastic fibers in the wall were more clearly identified than that of human. Electron microscopic study showed fewer type II alveolar endothelial cell and more and larger Kohn's pores than rat. These modified configuration in alveolar structure is considered to be morphological adaptive response to long term hypoxia.

Report

(3 results)
  • 1995 Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] 河野俊彦・三方敦男 栗山喬之: "ヤクの肺の組織学的構造に関する所見" 登山医学. 15. 129-134 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Masuyama,T.Kuriyama et.al.: "Preserved vagal tone and fractal property in HR variance in Sherpa" Hypoxia and the Brain. Eds.by R.Sutton. Queen City Printers Inc,Varmont. 330 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Masuyama,T.Kuriyama et.al.: "Camparison of Respiratory and Circrlatary interuction during progrssice hypoxia and acute hypobaric hypoxia" Respiratory and Critical Care Medicine. 153(4). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 三方淳男・増山茂 栗山喬之他: "ネパール王国におけるEBV関連腫瘍" 日本病理学会雑誌. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小林敏生.増山茂: "低地居住者の高所低酸素環境下における呼吸調節機能の適応" 日本衛生学雑誌. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 増山茂 栗山喬之他: "低酸素換気応答は息こらえの決定因子となるか?" 日本胸部疾患学会雑誌. vol 340. 256 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Honda,A Masuda,T.Kobayashi,M.Tanaka,H Kimura,S.Masuyama T.Kuriyama: "Proceedings of the London Conference on Modeiliy and control of ventilation" Plenam Press, (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 増山 茂: "中高年のための登山学" 日本放送出版協会, 159 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Kohono, A.Mikata and T.Kuriyama: "A histological study on the respiratory organ of Yak." Japanese Journal of Mountain Medicine. 15. 129-133 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Masuyama, Y.Honda, T.Kuriyama et al.: "Preserved vagal tone and fractal property in HR variance in Sherpa" "Hypoxia and Brain" eds. By Sutton et al. Queen Printers Inc., Vermont. 330 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Mizoo, S.Masuyama, T.Kuriyama et al.: "Comparison of Respiratory and Circulatory interaction during progressive hypoxia and acute hypobaric hypoxia." Respiratory and Critical Care Medicine. 154 (4). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Mikata, T.Kuriyama, S.Masuyama et al.: "EBV related tumors in Nepal" Japanese Journal of Pathology. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Kobayashi and S.Masuyama: "Altitude acclimatization of respiratory functions in lowlanders" Japanese journal of Hygiene. 51 (1). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Honda, A.Masuda, T.Kobayashi, M.Tanaka, S.Masuyama and T.Kuriyama: "Individual difference in ventilation and HR responses to progressive hypoxia following 100% O2 exposure in humans" Proceeding of the London Conference on modeling and control of ventilation. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 増山 茂: "ネパールクンブ-地域での日本の医学的貢献" 登山医学. 14. 161-166 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 増山 茂: "キルギスタン共和国からの手紙" 登山医学. 14. 173-188 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.K.Prasai,S.Masuyama and T.Kuriyama: "Tuberculosis and other problems in the land of rich and beautiful mountains" Japanese Journal of Mauntain Medicine. 14. 153-160 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 早野真央 他: "ネパールの高地における居住環境" 登山医学. 14. 143-146 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 増田敦子 他: "100%酸素吸入後の低酸素に対する換気と心拍応答の比較研究" 登山医学. 14. 143-146 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 増山 茂: "Annial Review 呼吸器" 中外医学社, 250 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 増山茂・栗山喬之: "呼吸器症候群" 日本臨床社, 1024 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 栗山喬之 他: "各種慢性肺疾患におけるCold Bressoor Testの肺循環動態へ及ぼす影響" 日本胸部疾患学会雑誌. 31. 206-213 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 栗山喬之 他: "初感染結核に対する化学療法" 結核. 68. 21-28 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 増山茂: "高所医学とオキシメーター" 呼吸と循環. 41. 733-740 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] A.Mikata et.al.: "Association of Epstein-Barr Virus with gastric carcinoma with lympoid stroma" Am.J.Pathol.143. 143. 1-8 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 肖和平・増山茂 他: "チベットにおける肺結核症の現状" 結核. 68. 113 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 早野真史・能川浩二 他: "ネパールの高地における居住環境" 日本衛生学雑誌. 49. 258 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 増山茂・栗山喬之: "Annuol Review 呼吸器 1993" 中外医学社, 250 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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