| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1993: ¥3,200,000 (Direct Cost: ¥3,200,000)
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| Research Abstract |
The northeast area of Thailand where the liver fluke parasite Opisthorchis viverrini (OV) is endemic and economically disadvantaged people eat raw fish harboring parasite metacercariae has a high incidence of cholangiocellular cancer. Previously we have demonstrated that OV infestation significantly enhances development of cholangiocellular carcinoma in hamster livers and that prolonged inflammation and regenerative epithelial hyperplasia may play important roles in development of cholangiocellular carcinomas in OV infested livers. The present investigation was performed to see whether there is any association between development of cholangiocellular carcinomas and infection with Clonorchis sinensis in Korea.
With assistance from Professor Soo Song, Department of Parasitology, College of Medicine Pusan National university, we collected pathological data on over 440 liver tumors surgically removed at Pusan National University and Kosin Medical College and Gospel Hospital in Pusan, Korea. Of these, 432 cases aged more than 20 years old were subjected to analysis. They comprised 337 males (mean age 50.9 years old (27-73 yrs)) and 95 females (mean age 51.2 years old (21-76 yrs)). Forty nine males (14.5%) and 12 females (12.6%) were revealed to be infected with liver flukes by stool examination and/or histopathology of the livers and 88 males and 24 females were negative for both examinations. Hepatocellular carcinomas and cholangiocellular carcinomas were present in 97 cases and 14 cases, respectively among the 112 infection-negative cases, whereas they were found in 32 and 28, respectively, of the 61 infection-positive cases. A significant difference (P<0.001, Fischer exact analysis) in the incidences of each type of carcinoma was evident between the infection-positive and negative groups.
Thus, these results clearly demonstrate that infection with Clonorchis sinensis is also a risk factor for development of cholangiocellular carcinomas.
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