| Project/Area Number |
05042007
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Kobe Women's College of Pharmacy |
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Principal Investigator |
KATO Atsushi Professor, Kobe Women's College of Pharmacy, 薬学部, 教授 (50068326)
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| Co-Investigator(Kenkyū-buntansha) |
アルバート R. チンバザサ動植物園, 園長
MATHENGE S.G. Lecture, University of Nairobi Department of Botany, 植物学部, 講師
OGET J.O. Associate professor. University of Nairobi Department of Pharmacy, 薬学部, 助教授
JUMA F.D. Professor, University of Nairobi Department of Medicine, 医学部, 教授
NISHIYAMA Yumi Assistant, Kobe Women's College of Pharmacy, 薬学部, 助手 (30248116)
TACHIBANA Yoko Assistant, Kobe Women's College of Pharmacy, 薬学部, 助手 (20207054)
ALBERT R. Director, Botanical and Zoological Park, Tsimbazaza
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| Project Period (FY) |
1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1993: ¥7,000,000 (Direct Cost: ¥7,000,000)
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| Keywords | Anticancer substance / Mitogenic activity / Rhizophoraceae / Antipromotin on EB-virus activation / Triterpenoid / Meliaceae / African ethnic crude drug / Sulfur containing alkaloid |
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| Research Abstract |
Many naturally occurring anticancer substances have isolated from plants and marine products, and also their chemical modifications tried for further effect and safety as medicine in various institutes. Some these compounds are used as clinical medicines. More study on anticancer substance in natural resources is desired at present. Therefore, in order to find new anticancer substances in the tropical plants, the field researches in East Africa, especially, in Kenya, Tanzania and Madagascar were carried out by us in 1993.
For selection of collecting plants, we have adapted an approach to traditional medicines of tribes and unused medicinal resources.
A total of 110 species of plants was collected during the research. Among these plants, some species have been tried to test physiological activities, and were expected to exhibit anticancer activity from results of first screening tests such as an inhibition test on EB-virus activation, a stimulation index on human peripheral blood lymphocytes and mouse spleen lymphocytes and a growth inhibition of HGC-27 cells.
For the other species, a screening test related to anticancer activity will be done to find useful natural products from the plants.
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