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Studies on development of HFRS vaccine and therapeutics

Research Project

Project/Area Number 05044144
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionHokkaido University

Principal Investigator

ARIKAWA Jiro  Hokkaido University・School of Medicine・Professor, 医学部, 教授 (10142704)

Co-Investigator(Kenkyū-buntansha) AKE Lundkvis  Swedish Institute for Infectious Disease, Associate
BO Niklasson  Swedish Institute for Infectious Disease, Professor
SONG Gan  Chinese Academy of Preventive Medicine・Virus Institute・Professor, 病毒学研究所, 教授
MORIMATSU Kumiko  Hokkaido University・School of Medicine・Assistant Professor, 医学部, 助手 (90220722)
SUGIYAMA Kazuyoshi  National Institute of Japan・Section of Virus・Chief Researcher, ウイルス一部, 室長 (90150185)
HASHIMOTO Nobuo  Hokkaido University・Grduate School of Veterinary Medicine・Professor, 獣医学部, 教授 (60082103)
LUNDKVIST Ake  Swedish Institute for Infectious Disease Control・Associate Professor
NIKLASSON Bo  Swedish Institute for Infectious Disease Control・Professor
NIKLASSON Bo  Swedish Institute for Infectious Disease, Professor
周 桂珍  中国予防医学科学院, 病毒学研究所, 助手
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 1995: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1994: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1993: ¥4,000,000 (Direct Cost: ¥4,000,000)
KeywordsHemorrhagic fever with renal syndrome / HFRS / Hantavirus / Vaccine / Hantavirus
Research Abstract

1.In 1993 and 1995, head investigator (Dr. Arikawa), and Japanese investigators (Drs. Hashimoto, Morimatsu, Kariwa) visited Swedish Institute for Infectious Disease control, and Helsinki University Institute for Virology and made information exchange and discussions along with this research project.
2.In 1993, Chinese investigators (Dr. Song and Hun), in 1995, Swedish investigators (Drs. Niklasson and Lundkvist) visited institutions of Japanese investigator such as Hokkaido University, National Institute Health of Japan and Osaka University to do information exchange and discussions along with this research project.
3.In 1994, Japanese investigator, Dr. Morimatsu, stayd at Swedish Institute for Infectious Disease control for 2 months to accomplish technical exchange concerning to antibody measurements by ELISA with reduced level of nonspecific background reaction and material exchange of monoclonal antibodies.
4.In 1994, Chinese investigator, Dr. Zhou, stayd at Hokkaido University for 6 m … More onths and neutralizing antibody response of vaccinee sera from China was examined. To measure the antibody, ELISA system which established by Swedish investigator and recombinant antigen which produced by Japanese investigator, were effectively applied. The obtained result was important for assess efficacy of Chinese vaccine.
5.In 1994, head investigator (Dr. Arikawa) visited the institute of Chinese investigator (Chinese Academy of Preventive Medicine) for discussing this research project and carried out preliminary field survey for collecting wild rodents.
6.In 1995, Japanese investigators, Drs. Sugiyama and Ami of National Institute of Health Japan, visited the Chinese Academy of Preventive Medicine and carried out field survey at suburbs of Beijing and Xian to collect field rodents. They examined the antigen distribution in the rodents by histochemical observations. Through the investigation, they established the system for collecting wild animals organs under the collaboration of Chinese investigators and examine viruses in the organs. This survey system will contribute for future collaboration study. Less

Report

(3 results)
  • 1995 Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Kumiko Yoshimatsu: "Application of a recombinant baculovirus expressing hantavirus nucleocapsid protein as a diagnostic antigen in IFA test : reactivities among 3 serotypes of hantavirus which causing hemorrhagic fever with renal syndrome (HFRS)." Journal of Veterinary Medical Science. 55. 1047-1050 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Jiro Arikawa: "Epizootiological studies of hantavirus infection among urban rats in Hokkaido,Japan : Evidences : for the persistent infection from the seroepizootiological surveys and antigenic characterizations of hantavirus isolates." Journal of Veterinary Medical Science. 56. 27-32 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroaki Kariwa: "Comparison of nucleotide sequences of M genome segments among Seoul virus strains isolated from Eastem Asia" Virus Research. 33. 27-38 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroaki Kariwa: "Enhancement of infectivity of hantavirus in cell culture by centrifugation" Journal of Virological Methods. 49. 235-244 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroaki Kariwa: "Characterization of the mode of Hantaan virus infection in adult mice using a nested reverse transcriptase polymerase chain reaction : transient virus replication in adult mice" Microbiology and Immunology. 39. 35-41 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumiko Yoshimatsu-Morimatsu: "Production of recombinant Hantavirus nucleocapsid protein expressese in silkworm larvae and its.use.as a diagnostic antigen in detecting antibodies in serum from intectd rats" Laboratory Animal Science. 45. 641-646 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroaki Kariwa: "Evidence for the existence of Puumalarelated virus among Clethrionomys rufocanus in Hokkaido,Japan" American Journal of Tropical Medicine and Hygiene. 53. 222-227 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yung-Choon Yoo: "Effect of MDP-Lys (L18),a derivative of MDP,on enhancing host resistance against Hantaan virus infection in newborn mice" Vaccine. 13. 1300-1305 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumiko Yoshimatsu-Morimatsu: "Western blotting using recombinant Hantaan virus nucleocapsid protein expressed in silkworm as a serological confirmation of Hantavirus infection in human sera" Joumal of Veterinary Medical Science. 58. 71-74 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumiko Yoshimatsu-Morimatsu: "Characterization of the nucleocapsid protein of Hantaan virus strtain 76-118 using monoclonal antibodies" Journal of General Virology. 77. 695-704 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumiko Yoshimatsu: "Application of a recombinant baculovirus expressing hantavirus nucleocapsid protein as a diagnostic antigen in IFA test, : reactivities among 3 serotypes of hantavirus which causing hemorrhagic fever with renal syndrome (HFRS)." Journal of Veterinary Medical Science. 55. 1047-1050 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Jiro Arikawa: "Epizootiological studies of hantavirus infection among urban rats in Hokkaido, Japan : Evidences : for the persistent infection from the sero-epizootiological surveys and antigenic characterizations of hantavirus isolates." Journal of Veterinary Medical Science. 56. 27-32 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroaki Kariwa: "Comparison of nucleotide sequences of M genome segments among Seoul virus strains isolated from Eastern Asia" Virus Research. 33. 27-38 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroaki Kariwa: "Enhancement of infectivity of hantavirus in cell culture by centrifugation" Journal of Virological Methods. 49. 235-244 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroaki Kariwa: "Characterization of the mode of Hantaan virus infection in adult mice using a nested reverse transcriptase polymerase chain reaction : transient virus replication in adult mice" Microbiology and Immunology. 39. 35-41 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumiko Yoshimatsu-Morimatsu: "Production of recombinant Hantavirus nucleocapsid protein expressese in silkworm larvae and its use as a diagnostic antigen in detecting antibodies in serum from infectd rats" Laboratory Animal Science. 45. 641-646 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroaki Kariwa: "Evidence for the existence of Puumala-related virus among Clethrionomys rufocanus in Hokkaido, Japan" American Journal of Tropical Medicine and Hygiene. 53. 222-227 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yung-Choon Yoo: "Effect of MDP-Lys (L18), a derivative of MDP,on enhancing host resistance against Hantaan virus infection in newborn mice" Vaccine. 13. 1300-1305 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumiko Yoshimatsu-Morimatsu: "Journal of Veterinary Medical Science" Western blotting using recombinant Hantaan virus nucleocapsid protein expressed in silk worm as a serological confirmation of Hantavirus infection in human sera. 58. 71-74 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumiko Yoshimatsu-Morimatsu: "Characterization of the nucleocapsid protein of Hantaan virus strtain 76-118 using monoclonal antibodies" Journal of General Virology. 77. 695-704 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kumiko Yoshimatsu: "Application of a recombinant baculovirus expressing hantavirus nucleocapsid protein as a diagnostic antigen in IFA test':reactivities among 3 serotypes of hantavirus which causing hemorrhagic fever with renal shydrome(HFRS)." Journal of Veterinary Medical Science. 55. 1047-1050 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Jiro Arikawa: "Epizootiological studies of hantavirus infection among urban rats in Hokkaido,Japan:Evidences:for the persistent infection from the sero-epizootiological surveys and antigenic characterizations of hantavirus isolates." Journal of Veterinary Medical Science. 56. 27-32 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kumiko YOSHIMATSU: "Application of a recombinant baculovirus expressing hantavirus nucleocapsid protein as a diagnostic antigen in IFA test:reactivities among 3 serotypes of hantavirus which causing hemorrhagic fever with renal syndrome(HFRS)" Journal of Veterinary Medical Science. 55. 1047-1050 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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