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The role of stress protein-reactive gammadeltaT cells in infection

Research Project

Project/Area Number 05044178
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MATSUZAKI Goro  Dept.Immunol., Med.Inst.Bioreg., Kyushu Univ. Assistant Professor, 生体防御医学研究所, 助手 (30229455)

Co-Investigator(Kenkyū-buntansha) IVANYI Juraj  Medical Research Council, Tuberculosis and Related Infections Unit, Professor, 教授
JURAJ Ivanyi  MRC, 結核および関連疾患部, 教授
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1994: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1993: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsgammadeltaT cells / stress protein / bacterial infection / 自己反応性 / hsp60
Research Abstract

We have reported that gammadeltaT cells reactive to stress protein increase at early stage of Listeriainfection. We also found that stress protein-reactive gammadeltaT cells increase in syngeneic mixed lymphocyte reaction (MLR). From the observations, we estimated that self stress protein/bacterial stress protein-cross reactive gammadeltaT cells increase after bacterial infection. Therefore we analyzed self-reactive gammadeltaT cells to know further characteristics of stress protein-reactive gammadeltaT cells.
We establisher 8 self-reactive gammadeltaT cell hybridomas. Four hybridomas expressed Vdelta5 and four hybridomas expressed Vdelta6. Response of seven out of eight self-reactive gammadeltaT cell hybridomas was blocked by anti stress protein (Hsp60) -monoclonal antibody ML30. Since response of gammadeltaT cell hybridomas with different T cell receptor was blocked with the ML30 antibody, we reasoned that Hsp60 molecule, but not ML30 epitope of Hsp60, participate in antigen recognition by the gammadeltaT cell hybridomas.

Report

(2 results)
  • 1994 Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Ivanyi,I.,Norton,P.,and Matsuzaki,G.: "Stress Proteins in Medicine" (in press), (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ivanyi, J., Norton, P., and Matsuzaki, G.: (in press). Stress Proteins and Medicine, (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Kobayashi,G.Matsuzaki,Y.Yoshikai,R.Seki,J.Ivanyi,K.Nomoto: "Vδ5+T cells of BALB/c mice recognize the murine heat shock protein target specificity" Immunology. 81. 240-246 (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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