Studies of concentric sclerosis (Balo) in the Philippines

Research Project

Project/Area Number	05044194
Research Category	Grant-in-Aid for international Scientific Research
Allocation Type	Single-year Grants
Section	Joint Research
Research Institution	National Institute of Neuroscience
Principal Investigator	TABIRA Takeshi National Institute of Neuroscience, 神経研究所, 部長 (80112332)
Co-Investigator(Kenkyū-buntansha)	コンデベルナルド・ジョサントトマス大学, 医学部, 助教授バナロホセ・C. サントトマス大学, 医学部, 助教授オルディナリオアルテミサントトマス大学, 医学部, 主任教授 YAMAMURA Takashi ibid, 神経センター神経研究所, 室長 (90231670) NAVARRO Jose c. ibid CONDE Bernardo George l. ibid ORDINARIO Artemio t. Faculty of Medicine and Surgery, University of Santo Tomas ベルナルド.ジョージ.L コンテサントトマス大学, 医学部・神経内科, 助教授ホセ.C ナバロサントトマス大学, 医学部・神経内科, 助教授アルテミオ.T オルディサントトマス大学, 医学部・神経内科, 主任教授
Project Period (FY)	1993 – 1994
Project Status	Completed (Fiscal Year 1994)
Budget Amount *help	¥6,500,000 (Direct Cost: ¥6,500,000) Fiscal Year 1994: ¥3,500,000 (Direct Cost: ¥3,500,000) Fiscal Year 1993: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywords	Concentric Sclerosis / Multiple Sclerosis / Demyelination / HLA / 脱髄疾患 / 急性散在性脳脊髄炎 / 髄鞘 / 脳炎
Research Abstract	We investigated the patients with Balo's concentric sclerosis in the Philippines. A total of 34 cases was collected in 2 years. Mean age of onset was 26.5 years and male to female ratio was 1 : 1.6. Patients developed acute onset of behavioral change, muteness, quadi- or hemiplegia with double incontinence, and responded to steroids. CSF was not remarkable except for slightly elevated white blood cell count and IgG,and MRI showed multifocal or diffuse confluent lesions in the cerebral white matter. The clinical course was monophasic except for one who showed one relapse. We found 2 familial cases. HLA-DRB11502 was found in 74% of Balo's patients, which was significantly higher than controls (36%) . Moreover, homozygote of DRB11502 was found in 44% of Balo's patients, which was significantly higher than MS (0%) and controls (5.6%) . No significant immune response to myelin basic protein and proteolipid protein was found, and none of virus antibodies were significant.