| Project/Area Number |
05234101
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Research Institution | Kyoto University (1994-1996)
Hokkaido University (1993) |
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Principal Investigator |
HAYASHI Tamio Kyoto University, Graduate School of Science, Professor, 大学院・理学研究科, 教授 (00093295)
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| Co-Investigator(Kenkyū-buntansha) |
HIYAMA Tamejiro Tokyo Institute of Technology, Research Laboratory of Resources Utilization, Pro, 資源化学研究所, 教授 (90026295)
SHIBASAKI Masakatsu University of Tokyo, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (30112767)
KITAMURA Masato Nagoya University, Graduate School of Science, Associate Professor, 大学院・理学研究科, 助教授 (50169885)
KATSUKI Tsutomu Kyushu University, Faculty of Science, Professor, 理学部, 教授 (40037271)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥79,000,000 (Direct Cost: ¥79,000,000)
Fiscal Year 1995: ¥31,000,000 (Direct Cost: ¥31,000,000)
Fiscal Year 1994: ¥26,600,000 (Direct Cost: ¥26,600,000)
Fiscal Year 1993: ¥21,400,000 (Direct Cost: ¥21,400,000)
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| Keywords | Catalytic Asymmetric Synthesis / Transition-Metal Catalyst / Asymmetric Hydrogenation / Asymmetric Oxidation / Asymmetric Hydrosilylation / Asymmetric Aldol Reaction / Asymmetric Coupling |
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| Research Abstract |
Among various types of asymmetric reactions, reaction with a chiral catalyst is obviously the best choice, because the catalytic asymmetric synthesis requires ideally only one molecule of a chiral catalyst in order to produce a large quantity of an optically active substance. During 1993-1995, we developed new chiral transition-metal catalysts and used them successfully for several types of catalytic asymmetric reactions including asymmetric carbon-carbon bond forming reactions. The examples are : 1) Asymmetric hydrosilylation of olefins catalyzed by a palladium complex coordinated with new monodentate phosphine ligand MOP.2) Asymmetric epoxidation of olefins with new salen-manganese catalysts. 3) Asymmetric nitro-aldol reactions catalyzed by hetero-bimetallic systems.
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