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Development of Mediator Reaction

Research Project

Project/Area Number 05235102
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionTohoku University

Principal Investigator

OSA Tetsuo  Tohoku University, Emeritus, Professor, 名誉教授 (10010753)

Co-Investigator(Kenkyū-buntansha) MATSUMURA Yoshihiro  Nagasaki University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (60026309)
MATSUE Tomokazu  Tohoku University, Faculty of Engineering, Associate Professor, 工学部, 助教授 (70173797)
TANIGUCHI Isao  Kumamoto University, Faculty of Engineering, Professor, 工学部, 教授 (90112391)
UNEYAMA Kenji  Okayama University, Faculty of Engineering, Professor, 工学部, 教授 (00033150)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥92,300,000 (Direct Cost: ¥92,300,000)
Fiscal Year 1995: ¥21,300,000 (Direct Cost: ¥21,300,000)
Fiscal Year 1994: ¥25,000,000 (Direct Cost: ¥25,000,000)
Fiscal Year 1993: ¥46,000,000 (Direct Cost: ¥46,000,000)
KeywordsMediator reaction / Bioelectrocatalytic reaction / Mediator-modified electrode / Mediator- and enzyme-multimodified electrode / ferredoxin / Fluoroselenation / Oxidative coupling / Scanning electrochemical microscopy / キラルメディエーター修飾電極 / メディエーター酵素複合修飾電極 / フルオロフェニルセレニド / 電極還元活性塩基 / 癌胎児性抗原 / 修飾電極 / エナンチオ選択的反応 / 生物電気化学反応器 / 分光電気化学 / トリフルオロエタノール / 電解フッ素化 / 酵素マイクロパターン / 生物電気化学反応 / マイクロ電極 / 酵素反応
Research Abstract

Investigation of this group extended modiator reactions for electrocatalytic synthesis of organic compounds, together with dynamic and static analysis of electron transfer mechanism and processes.
1.Stereoselective Electroorganic Synthesis on Mediator-modified Electrodes and Mediator-and Enzyme-multimodified Electrodes (OSA) Poly (acrylic acid) -coating graphite felt electrodes immobilizing mediator, enzme and/or co-enzyme have developed enantioselective and electrocatalytic (electroenzymatic) reactions for several types of organic compounds. Actually, the preparative oxidations have not only been achieved on the achiral TEMPO-modified and chiral TEMPO-modified electrodes in the presence of chiral base and achiral base, respectively, but the preparative oxidations and reductions also done on the enzyme-multimodified electrodes in high enantioselectivity, high current efficiency and high conversion.
2.Bioelectrochemical Conversion with Ferredoxin as Mediator (TANIGUCHI) Reduced ferredoxin … More at the functional modified electrodes possessing a cationic surface has been successfuly used as an electron transfer mediator to develop various new bioelectrocatalytic reactions via ferredoxin-NADP+ -reductase as in nature. For example, L-glutamic acid and L-malic acid were effectively produced. Using site-directed mutagenetic techniques, functions of amino acids in ferredoxin have also been studied.
3.Creation of New Mediator systems (UNEYAMA and MATSUMURA) A new electrochemical method for fluoro-functionalization has been developed. Electro-oxidation and reduction of diphenyl diselenide generate benzene seleneny. Ifluoride and benzene selenate which mediate efficiently fluoro-selenation and difluoromethyl-selenation of olefins, respectively (UNEYAMA). A new electrochemical oxidation system and a new mediatory system have been exploited for highly efficient oxidation of hardly oxidizable organic compounds. A reaction system consisting of electrochemically generated base has also been found with iodine molecule, which was suitable to a stereoselective synthesis of C2-symmetric compounds and an asymmetric oxidative coupling (MATSUMURA).
4.Analysis of Mediator Reactions (MATSUE) The kinetic parameters of some redox enzymes have been determined by quantitative analyzes of mediator reactions. A scanning electrochemical microscopy (SECM) has been fabricated for characterization of localized mediator processes. The SECM technique was combined with immunoassay system for trace bioanalysis. Less

Report

(4 results)
  • 1996 Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (125 results)

All Other

All Publications (125 results)

  • [Publications] Yoshitomo Kashiwagi: "The Effects of Chain Length of Ferrocene Moiety on Mediator-and Enzymes-Modified Electrode" Denki Kagaku. 62. 1240-1246 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tetsuo Osa: "Enantioselective,Electrocatalytic Oxidative Couplings of Naphthols,Naphthyl Ether and Phenanthrol on a TEMPO-Modified Graphite Felt Electrode in the Presence of(-)-Sparteine" Journal of Chemical Society,Chemical Communications. 2535-2537 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tomonori Hoshi: "Controlled Deposition of Glucose Oxidase on Platinum Electrode Based on Avidin/Biotin for the Regulation of Output Current of Glucose Sensor" Analytical Chemistry. 67. 770-774 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tomonori Hoshi: "Use of Electrodeposited Avidin Film ffor the Preparation of Lactate and Choline Sensors" Analytical Sciences. 11. 311-312 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshinori Yanagisawa: "Enantioselective,Electrocatalytic Lactonization of Methyl-substituted Diols on a TEMPO modified Graphite Felt Elecctrode in the Presence of(-)-Sparteine" Chemistry Letters. 1043-1044 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshitomo Kashiwagi: "Preparative,Electroenzymatic Reduction of NAD+ to NADH on a Thin Poly(Acrylic Acid)Layer-Coated Graphite Felt Electrode Coimmobilizing Ion-paired Methyl Viologen-Cation-Exchange Polymer and Diaphorase" Chemistry Letters. 1093-1094 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshitomo Kashiwagi: "Enantioselective,Electrocatalytic Oxidation of Racemic Alcohols on TEMPO modified Graphite Felt Elecctrode by Use of Chiral Base(TEMPO=2,2,6,6-trtramethylpiperidin-1-yloxyl)" Chemical Communications. 2745-2746 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshitomo Kashiwagi: "Preparative,Electroenzymatic Reduction of Ketones on an all Components-Immobilized Grafite Felt Electrode" Electrochimica Acta. (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Asai: "A New Entry to Difluoromethylene Compound" Chemistry Letters. 1123-1124 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masafumi.Kobayashi: "Syntheses of Trifluoromethylated 6-Hydroxybenzimidazoles and Spiro Dienone Derivatives" Journal of Organic Chemistry. 60. 6402-6407 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masafumi Kobayashi: "Synthesis of 2-(Perfluoroalkyl)benzimidazoles by Oxidative Intermolecular Cyclization" Journal of Organic Chemistry. 61. 3902-3905 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kenji Uneyama: "Electrchemical Generation of(PhSeF)for Selenation of Alkenes and Alkynes" Electrochimica Acta. (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Isao Taniguchi: "Polypeptide Modified Indium Oxide Electrodes for Direct Electron Transfer of Ferredoxine" Journal of Chemical Society,Chemical Communications. 953-954 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Isao Taniguchi: "Potential-Dependent Rectified Electron-Transfer at a Meldola's Blue Incorporated Decanethiol Modified Electrode as Model of Biological Membrane" Microchemical Journal. 49. 340-354 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 谷口 功: "生体分子の電気化学とその応用" 化学工業. 45. 52-57 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 谷口 功: "金属タンパク質の電子移動制御と電子機能素子の構築" 生物物理. 34. 52-57 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katsuhiko Nishiyama: "Aminosilane Modified Indium Oxide Electrodes for Direct Electron Transfer of Ferrodoxin" Journal of Electroanalytical Chemistry. 373. 255-258 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Isao Taniguchi: "In Situ Circular Dichrosim Spestroelectrochemistry of Spinach Ferredoxin Using a Promoter Modified Indium Oxide Electrode" Denki Kagaku. 62. 985-986 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 谷口 功: "金属タンパク質の直接電子移動制御のための機能分子修飾電極デザイン" 化学と工業. 47. 1441-1443 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 谷口 功: "金属タンパク質に対するプローブとしての電気化学的手法" ぶんせき. 860-861 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] F.M.Hawkridge: "The Direct Electron Transfer Reactions Cytochrome c at Electrode Surfaces" Comments on Inorganic Chenistry. 17. 163-187 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Isao Taniguchi: "Electrochemical Behavior of the Enzyme Reaction of Chlorella Ferredoxin-FNR-NADP^+ System" Denki Kagaku. 63. 1191-1192 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Takahashi: "Spectroelectrochemical Study of Some μ_3-Oxo-μ-acetate Trinuclear Rhodium(III)and Iridium(III)Complexes" Z.Naturforsch.50b. 551-557 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Ishiyama: "Novel Disulfonated Tetrazolium Salt That can be Reduced to a Water-soluble Formazan and its Application to the Assay of Lactate Dehydrogenase" Analyst(London). 120. 113-116 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Isao Taniguchi: "Electrochemistry of monoazahemin reconstituted myogrobin at an indium oxide electrode" Journal of Electroanalytical Chemistry. (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Matsumura: "A New Reaction System for Efficient Electrochemical Oxidation of N-methoxycarbonyl-2,2,2-trifluoroethylamines" Tetrahedron Letters. 35. 1271-1274 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Matsumura: "Electrochemical Oxidation of Secondary Alcohols Using Thioanisole as an Organic Mediator in the Presence of 2,2,2-Trifluorroethanol" Tetrahedron. 51. 6411-6418 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Kise: "Enantioselective Synthesis of 2,3-Disubstituted Succinic Acids by Oxidative Homocoupling of Optically Active 3-Acyl-2-Oxazolidones" Journal of Organic Chemistry. 60. 1100-1101 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Matsumura: "Dependence of the Reactivities of Titanium Enolates on How They Area Generated:Diastereoselective Coupling of Phenylacetic Acid Esters Using Tianium Tetrachloride" Journal of Organic Chemistry. 61. 2809-2812 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Matsumura: "Stereoselective Homocoupling of Phenylacetic Acid Derivatives Utilizing Electrochemically Generated Base" Electrochimica Acta. (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Miwa: "Electrocatalytic Oxidation of Alcohol at a Polypyrrole Diaphragm Electrode Coated with Diaphorase and Alcohol Dehydrogenase" Denki Kagaku. 62. 1256-1257 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Shiku: "Microfabrication and Characterization of Diaphrase-Patterned Surfaces by Scanning Electrochemical Microscopy" Analytical Chemistry. 67. 312-317 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Shiku: "Detection of Microsspotted Carcinoembryonic Antigen on a Glass Substrate by Scanning Electrochemical Microscopy" Analytical Chemistry. 68. 312-317 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Kasai: "Multichannel Electrochemical Analyses of Enzyme Reactions" Electroanalysis. 8. 748-752 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Shiku: "Dual Immunoassay of Human Chorionic Gonadotropin and Human Placental Lactogen at a Microfabricated Substrate by Scanning Electrochemical Microscopy" Journal of Electroanalytical Chemistry. (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I.Taniguchi: "Redox Mechanisms and Interfacial Properties of Molecules of Biological" Electrochemical Society Inc., 245 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 戸田不二緒: "シクロデキストリン(5.4シクロデキストリンと電気化学)" 産業図書, 348 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshitomo Kashiwagi: "The Effects of Chain Length of Ferrocene Moiety on Mediator- and Enzymes-Modified Electrode" Denki Kagaku. 62. 1240-1246 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tetsuo Osa: "Enantioselective, Electrocatalytic Oxidative Couplings of Naphthols, Naphthyl Ether and Phenanthrol on a TEMPO-Modified Graphite Felt Electrode in the Presence of (-) -Sparteine" Journal of Chemical Society, Chemical Communications. 1994. 2535-2537

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tomonori Hoshi: "Controlled Deposition of Glucose Oxidase on Platinum Electrode Based on Avidin/Biotin for the Regulation of Output Current of Glucose Sensor" Analytical Chemistry. 67. 770-774 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tomonori Hoshi: "Use of Electrodeposited Avidin Film ffor the Preparation of Lactate and Choline Sensors" Analytical Sciences. 11. 311-312 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshinori Yanagisawa: "Enantioselective, Electrocatalytic Lactonization of Methyl-substituted Diols on a TEMPO modified Graphite Felt Electrode in the Presence of (-) -Sparteine" Chemistry Letters. 1996. 1043-1044

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshitomo Kashiwagi: "Preparative, Electroenzymatic Reduction of NAD^+ to NADH on a Thin Poly (Acrylic Acid) Layr-Coated Graphite Felt Electrode Coimmobilizing Ion-paired Methyl Viologen-Cation-Exchange Polymer and Diaphorase" Chemistry Letters. 1996. 1093-1094

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshitomo Kashiwagi: "Enantioselective, Electrocatalytic Oxidation of Racemic Alcohols on TEMPO modified Graphite Felt Electrode by Use of Chiral Base (TEMPO=2,2,6,6-trtramethylpiperidin-1-yloxyl)" Chemical Communications. 1996. 2745-2746

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshitomo Kashiwagi: "Preparative, Electroenzymatic Reduction of Ketones on an all Components-Immobilized Grafite Felt Electrode" Electrochimica Acta. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Asai: "A New Entry to Difluoromethylene Compound" Chemistry Letters. 1995. 1123-1124

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masafumi Kobayashi: "Syntheses of Trifluoromethylated 6-Hydroxy-benzimidazoles and Spiro Dienone Derivatives" Journal of Organic Chemistry. 60. 6402-6407 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masafumi Kobayashi: "Synthesis of 2- (Perfluoroalkyl) benzimidazoles by Oxidative Interamolecular Cyclization" Journal of Organic Chemistry. 61. 3902-3905 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kenji Uneyama: "Electrchemical Generation of (PhSeF) for Selenation of Alkenes and Alkynes" Electrochimica Acta. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Isao Taniguchi: "Polypeptide Modified Indium Oxide Electrodes for Direct Electron Transfer of Ferredoxine" Journal of Chemical Society, Chemical Communications. 1994. 953-954

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Isao Taniguchi: "Potential-Dependent Rectified Electron-Transfer at a Meldola's Blue Incorporated Decanethiol Modified Electrode as Model of Biological Membrane" Microchemical Journal. 49. 340-354 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katsuhiko Nishiyama: "Aminosilane Modified Indium Oxide Electrodes for Direct Electron Transfer of Ferrodoxin" Journal of Electroanalytical Chemistry. 373. 255-258 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Isao Taniguchi: "In Situ Circular Dichrosim Spestroelectrochemistry of Spinach Ferredoxin Using a Promoter Modified Indium Oxide Electrode" Denki Kagaku. 62. 985-986 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] F.M.Hawkridge: "The Direct Electron Transfer Reactions Cytochrome c af Electrode Surfaces" Comments on Inorganic Chemistry. 17. 163-187 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Isao Taniguchi: "Electrochemical Behavior of the Enzyme Reaction of Chlorella Ferredoxin-FNR-NADP^+ System" Denki Kagaku. 63. 1191-1192 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Takahashi: "Spectroelectrochemical Study of Some mu_3-Oxo-mu-acetate Trinuclear Rhodium (III) and Iridium (III) Complexes" Z.Naturforsch. 50b. 551-557 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Ishiyama: "Novel Disulfonated Tetrazolium Salt That can be Reduced to a Water-soluble Formazan and its Application to the Assay of Lactate Dehydrogenase" Analyst (London). 120. 113-116 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Iso Taniguchi: "Electrochemistry of monoazahemin reconstituted myogrobin at an indium oxide electrode" Journal of Electroanalytical Chemistry. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Matsumura: "A New Reaction System for Efficient Electrochemical Oxidation of N-methoxycarbonyl-2,2,2-trifluoroethylamines" Tetrahedron Letters. 35. 1271-1274 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Matsumura: "Electrochemical Oxidation of Secondary Alcohols Using Thioanisole as an OrganicMediator in the Presence of 2,2,2-Trifluoroethanol" Tetrahedron. 51. 6411-6418 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Kise: "Enantioselective Synthesis of 2,3-Disubstituted Succinic Acids by Oxidative Homocoupling of Optically Active 3-Acyl-2-Oxazolidones" Journal of Organic Chemistry. 60. 1100-1101 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Matsumura: "Dependence of the Reactivities of Titanium Enolates on How They Area Generated : Diastereoselective Coupling of Phenylacetic Acid Esters Using Tianium Tetrachloride" Journal of Organic Chemistry. 61. 2809-2812 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Matsumura: "Stereoselective Homocoupling of Phenylacetic Acid Derivatives Utilizing Electrochemically Generated Base" Electrochimica Acta. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Miwa: "Electrocatalytic Oxidation of Alcohol at a Polypyrrole Diaphragm Electrode Coated with Diaphorase and Alcohol Dehydrogenase" Denki Kagaku. 62. 1256-1257 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Shiku: "Microfabrication and Characterization of Diaphrase-Patterned Surfaces by Scanning Electrochemical Microscopy" Analytical Chemistry. 67. 312-317 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Shiku: "Detection of Microsspotted Carcinoembryonic Antigen on a Glass Substrate by Scanning Electrochemical Microscopy" Analytical Chemistry. 68. 312-317 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Kasai: "Multichannel Electrochemical Analyzes of Enzyme Reactions" Electroanalysis. 8. 748-752 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Shiku: "Dual Immunoassay of Human Chorionic Gonadotropin and Human Placental Lactogen at a Microfabricated Substrate by Scanning Electrochemical Microscopy" Journal of Electroanalytical Chemistry. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tomonori Hoshi: "Controlled Deposition of Glucose Oxidase on Platinum Electrode Based on an Avidin/Biotin for the Regulation of Output Current of Glucose Sensors" Analytical Chemistry. 67. 770-774 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tomonori Hoshi: "Use of Electrodeposited Avidin Film for the Preparation of Lactate and Choline Sensors" Analytical Sciences. 11. 311-312 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kenji Uneyama: "Reaction of Difluoromethyl Phenyl Selenoxide with Acetic Anhydride.A Route to Difluoro(phenylseleno)methylation of Ethers" Journal of Organic Chemistry. 60. 370-375 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yasufumi Dan-oh: "Generation and Reactions of Trifluoroacetimidoyl Radicals" Bulltin of the Chemical Society of Japan. 68. 1497-1507 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takashi Sakai: "Asymmetric Reduction of 2-(N-Arylamino)-3,3,3-trifluoro-propanoic Esters Leading to Chiral 3,3,3-trifluoroalanine and Its Derivatives" Synlett. 753-754 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Masashi Kobayashi: "Intramolecular Cyclization of Nl-(4-Oxo-2,5-cyclohexadine-1-ylidene)-N2-substitued-2,2,2-trifuluoroethanimidamides(p-Benzoqunone Imine Derivative):Syntheses of Trifluoromethylated 6-Hydroxybenzimidazoles and Spirodienone Diazacarbocycles" Journal of Organic Chemistry. 60. 6402-6407 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yasufumi Dan-oh: "Electrochemical Hydrotrifluoromethylation of Dialkyl Fumarates" Bulltin of the Chemical Society of Japan. 68. 2993-2996 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 宇根山健治: "フッ素を分子に組み入れる-合成ブロックの活用-ハロゲン化トリフルオロアセトイミドイルの化学" 有機合成化学協会誌. 53. 59-68 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Fred M.Hawkridge: "The Direct Electron Transfer Reactions of Cytochrome C at Electrode Surface" Comments of Inorganic Chemistry. 17. 163-187 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Isao Taniguchi: "Polypeptide-modified Indium Oxide Electrodes for Direct Electron Transfer of Ferredoxin" Journal of the Chemical Society,Chemical Communications. 953-954 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Katsuhiko Nishiyama: "Electrocatalytic Activity of Poly (tetrafluoroaniline)Film-Coated Electrode for Fe^<3+/2+> Redox" Journal of Electroanalytical Chemistry. 373. 255-258 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Isao Taniguchi: "Electrochemical Behavior of the Enzyme Reaction of Chlorella Ferredoxin-FNR-NAOP^+ System" Denki Kagaku. 63. 1191-1192 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hitoshi Shiku: "Microfabrication and Characterization of Diaphorase-Patterned Sueface by Scanning Electrochemical Microscopy" Analytical Chemistry. 43. 312-317 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Naoki Kise: "Enantioselective Synthesis of 2,3-Disubstituted Succinic Acids by Oxidative Homocoupling of Optically Active 3-Acyl-2-oxazolidones" Journal of Organic Chemistry. 60. 1100-1101 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 戸田不二雄: "シクロデキストリン(5・4シクロデキストリンと電気化学)" 産業図書, 348 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshitomo Kashiwagi: "The Effects of Chain Length of Ferrocene Moiety on Mediator-and Enzymes-Modified Electrode" Denki Kagaku. 62. 1240-1246 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tetsuo Osa: "Enantioselective,Electrocatalytic Oxidative Couplings of Naphthols,Naphthyl Ether and Phenanthrol on a TEMPO-Modified Graphite Fell Electrode in the Presence of (-)-Sparteine" Journal of Chemical Society,Chemical Communications. 2535-2537 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Masafumi Kobayasi: "Electrochemical Oxidation of 2-Substituted3-N-(Arylamino)-4,4,4-trifluoro-2-butenate;An Access to 3-Substituted 2-Trifluoromethyl-3H-indoles" Journal of Organic Chemistry. 59. 1909-1911 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kenji Uneyama: "Electrochemical Oxidation of N,N-Disubstituted Trifluoroethanimidamides;An Approach to N-Substituted-2-trifluoromethylbenzimidazoles" Journal of Organic Chemistry. 59. 3003-3014 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kenji Uneyama: "Electrochemical Generation of Trifluoroacetaldehyde from its Hemiacetal and Aldol Reaction with Active Methylene Compounds" Denki Kagaku. 62. 1151-1153 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Katsuhiko Nishiyama: "Aminosilane Modified Indium Oxide Electrodes for Direct Electron Transfer of Ferrodoxin" Journal of Electroanalytical Chemistry. 373. 255-258 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Isao Taniguchi: "In Situ Circular Dichrosim Spestroelectrochemistry of Spinach Ferredoxin Using a Promoter Modified Indium Oxide Electrode" Denki Kagaku. 62. 985-986 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hiroshi Yamada: "Microvoltammetric Characterization of Diaphorase Monolayer at Glass Surfaces" Bioelectrochemistry and Bioenergetcs. 33. 91- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tomokazu Matsue: "Pemselectivity of Voltage-Gated Alamethicin Ion Channel Studied by Microamperometry" Journal of Physical Chemistry. 98. 11001-11003 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yukihiro Miwa: "Electrocatalytic Oxidation of Alcohols a Polypyrrole Diaphragm Electrode Immobilized with Diaphorase and Alcohol Dehydrogenase" Denki Kagaku. 62. 1256-1257 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hitoshi Shiku: "Microfabrication and Characterization of Diaphorase-Patterned Surfaces by Scanning Electrochemical Microscopy" Analytical Chemistry. 67. 312-317 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshihiro Matsumura: "A Convenient Method for Introducing Oxo Group into the β-Position of Cyclic Amines and Its Application to Synthesis of δ-Aminolevulinic Acid" Bulletin of the Chemical Society of Japan. 67. 304-306 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshihiro Matsumura: "First Synthesis of Optically Pure α-Amino Amine as Asymmetric Amino Transfer Reagent and its Use in Asymmetric Mannich Reaction" Tetrahedron Letters. 35. 3737-3740 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshihiro Matsumura: "Selective Bond Cleavage of Borneol and Related Alcohols by Electrochemical Oxidation" Denki Kagaku. 62. 1154-1157 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Naoki Kise: "Diastereoselective Synthesis of Anti-and Syn-3-Amino-2-Hydroxylakanoic Acid Derivatives" Tetrahedron Letters. 36. 909-912 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshitomo Kashiwagi: "Electrocatalytic Oxidative Coupling Reaction of Naphthols and Naphthol Ethers" Chemistry Letters. 81-84 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshitomo Kashiwagi: "Electrocatalytic Oxidative Coupling of Methylquinolines on TEMPO-Modified Graphite Felt Electrode" Chemistry Letters. 257-260 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshitomo Kashiwagi: "Electrocatalytic Oxidation of NADH on Thin Poly(acrylic acid)Film Coated Graphite Felt Electrode Coimmobilizing Ferrocene and Diaphorase" Chemistry Letters. 677-680 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Iwao Suzuki: "Electrochemical Conversion of Alcohols into Aldehydes Mediated by Lipophilic γ-Cyclodextrin Bearing a Ferrocene Moiety" Chemistry Letters. 1719-1722 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 長哲郎: "高分子修飾電極を用いる電解合成" 化学工業. 45. 121-126 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tetsuo Osa: "Electroenzymatic Oxidation of Alcohols on a Poly(acrylic acid)-coated Graphite Felt Electrode Terimmobilizing Ferrocene,Diaphorase and Alcohol Dehydrogenase" Chemistry Letters. 367-370 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Masafumi Kobayasi: "Electrochemical Oxidation of 2-Substituted 3-N-(Arylamino)-4,4,4-trifluoro-2-butenate;An Access to 3-Substituted 2-Trifluoromethyl-3 H-indoles" Journal of Organic Chemistry. 59(印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kenji Uneyama: "Electrochemical Oxidation of N,N′-Disubstituted Trifluoroethanimidamides;An Approach to N-Substituted-2-trifluoromethylbenzimidazoles" Journal of Organic Chemistry. 59(印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Isao Taniguchi: "Direct Electron Transfer of Ferredoxins at Indium Oxide Electrode in the Presence of Poly-L-lysine" Denki Kagaku. 61. 774-775 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Isao Taniguchi: "Electrochemical Evaluation of the Surface Structures of Self-Assembling Promoter-modified Electrode for Protein Electrochemistry" Chemical Sensors Suppl.B.9. 239-242 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Masato Tominaga: "Effect of Suface Hydrophylicity of an Indium Oxide Electrode on Direct Electron Transfer of Myoglobin" Chemistry Letters. 131-138 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Isao Taniguchi: "Polypeptide Modified Indium Oxide Electrodes for Direct Electron Transfer of Ferredoxin" Journal of Chemical Society,Chemical Communications. 1994(印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Isao Taniguchi: "Potential-Dependent Rectified Electron-Transfer at a Meldola's Blue Incorporated Decanethiol" Michrochemical Journal. 49(印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 西山勝彦: "有機薄膜の電気化学" 信学技報. 93. 27-33 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 谷口功: "生体分子の電気化学とその応用" 化学工業. 45. 252-257 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 谷口功: "金属タンパク質の電子移動制御と電子機能素子の構築" 生物物理. 34(印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tomokazu Matsue: "Microring-ring Electrode for Manipulation of a Single Cell" Biochimica et Biophysica Acta. 1157. 332-335 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hiroshi Yamada: "Determination of Active Diaphorase Immobilized at Electrode Surfaces" Bioelectrochemistry and Bioenergetcs. 29. 337-346 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tomokazu Matsue: "Electrochemical Sensors Using Microarray Electrodes" Trends in Analytical Chemistry. 12. 100-108 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Matsuhiko Nishizawa: "Fabrication of pH-Sensitive Microarray Electrode and Applicability to Biosensors" Sensors and Actuators. 13-14. 53-56 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hiroshi Yamada: "Electrn-Transfer at a Planar Lipid Membrane Incorporated with 7,7,8,8-Tetracyanoquinodimethane Studied By AC Impedance Spectroscopy" Journal of Physical Chemistry. 97. 9547-9549 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tomokazu Matsue: "Microamperometric Estimation of Photosynthesis Inhibition in a Single Protoplast" Biochemical and Biophysical Research Communications. 197. 1283-1287 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Matsuhiko Nishizawa: "Surface Pretreatment for Electrochemical Fabrication of Ultrathin Patterned Conducting Polymers" Journal of Electrochemical Society. 140. 1650-1655 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshihiro Matsumura: "A New Reaction System for Efficient Electrochemical Oxidation of N-Methoxycarbonyl-2,2,2-trifluoroethylamines" Tetrahedron. 49. 8503-8512 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshihiro Matsumura: "A Convenient Route to β-Aryl-substituted Cyclic Enamines as Key Synthetic Intermadiates of Sceletium and Amaryllidaceae Alkaloids" Tetrahedron Letters. 35(印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Isao Taniguchi: "Redox Mechanisms and Interfacial Properties of Molecules of Biological Importance" Direct Electron Transfer Reactions of Proteins at Functional Electrodes(The Electrochemical Society,Inc.,Pennigton,U.S.A.), 12 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] B.C.King: "Redox Mechanisms and Interfacial Properties of Molecules of Biological Importance" Myoglobin Electron Transfer and Ligand Binding Reactions(The Electrochemical Society,Inc.,Pennigton,U.S.A.), 10 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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