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Tunneling Properties of Large Molecules

Research Project

Project/Area Number 05245102
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionTokyo Institute of Technology

Principal Investigator

IKAI Atsushi  Tokyo Inst.of Technology, Biosci., Professor, 生命理工学部, 教授 (50011713)

Co-Investigator(Kenkyū-buntansha) KAWAI Tomoji  Osaka Univ.Inst.Industrial Res., Professor, 産業科学研究所, 教授 (20092546)
HORIUCHI Toshihisa  Kyoto Univ.Fac.Engineering, Assistant, 工学部, 助手 (10238785)
KATSUMATA Shunji  Iwaki Meisei Univ.Sci.& Tech., Professor, 理工学部, 教授 (00002105)
HARA Masahiko  Riken Institute, Team Leader, フロンティア研究部門, 研究員 (50181003)
HATTA Ichiro  Nagoya Univ.Fac.of Engineering, Professor, 工学部, 教授 (70016070)
徳永 史生  大阪大学, 理学部, 教授 (80025452)
Project Period (FY) 1993 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥130,200,000 (Direct Cost: ¥130,200,000)
Fiscal Year 1996: ¥27,800,000 (Direct Cost: ¥27,800,000)
Fiscal Year 1995: ¥29,800,000 (Direct Cost: ¥29,800,000)
Fiscal Year 1994: ¥34,600,000 (Direct Cost: ¥34,600,000)
Fiscal Year 1993: ¥38,000,000 (Direct Cost: ¥38,000,000)
Keywordstunneling property / large molecule / STM / AFM / organic molecules / biomolecules / STM / 脂肪酸 / 脂肪族アルコール / ステアリン酸 / ステアロイルアミド / ステアロイルアニリド / タンパク質 / 生体膜 / 液晶 / 塩基
Research Abstract

This study aimed at the elucidation of tunneling properties of bio/organic molecules and structures which are generally known to be electrically non-conductive.
1 We were successful in imaging organic hydrocarbons with functional groups such as amine, carboxyl, anilide, alcohol, carbonyl, aryl, phenyl, cholestryl groups. The success opened a way to identify individual molecules by their functional groups in their mixed mono-layrs over the metal surface. Theoretical results of molecular orbital calculation of the intramolecular states of the electrons were applied to rationalize experimental identifications of such molecules.
2 Scanning tunneling and atomic force microscopes were used in imaging proteins and nucleic acids. Regular arrays of adsorbed proteins on a metal surface were studied with an aim to cultivate useful methods for the creation of functional monolayr surfaces. The four bases that make up the genomic DNA were identified uder tunneling microscope with the help of calculated electron distribution.
3 Methods of manipulation and engineering biomolecules and functional structures using atomic force microscope were developed. Stretching experiment of individual protein molecules and manipulation of the human genomic DNA in the chromosomes were successfully done.

Report

(5 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] IKAI,Atsushi: "STM and AFM of bio/organic molecules and structures" Surface Science Reports. 26. 261-332 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] MITSUI,Keita: "Mechanical unfolding of alpha-2-macroglobulin molecules with AFM" FEBS Letters. 385. 29-33 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takeuchi,Hideto: "Differentiation of chemically functional groups in stearoyl amide and anilide with STM" Jpn.J.Appl.Phys.35. 3754-3758 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] HARA,Masahiko: "Ordered nucleation of a self assembled monolayer on Au(111)studied by STM" Thin Solid Films. 273. 66-69 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] HIBINO,Masahiro: "STM study on dynamic structural frformation in mixed fatty acid monolayers" Thin Solid Films. 281. 594-597 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] KANETO,Keiichi: "Transport Mechanisms in evaports CO film evaluated by means of field effect" Jpn.J.Appl.Phys.35. 1802-1805 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] IKAI,Atsushi: "STM and AFM of bio/organic molecules and structures" Surface Science Reports. 26. 261-332 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] MITSUI,Keita: "Mechanical unfolding of alpha-2-macroglobulin molecules with AFM" FEBS Letters. 385. 29-33 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] TAKEUCHI,Hideto: "Differentiation of chemically functional groups in stearoyl amide and anilide with STM" Jpn.J.Appl.Phys.35. 3754-3758 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] HARA,Masahiko: "Ordered nucleation of a self assembled monolayr or Au (111) studied by STM" Thin Solid Films. 273. 66-69 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] HIBINO,Masahiro: "STM study on dynamic structural frformation in mixed fatty acid monolayrs" Thin Solid Films. 281. 594-597 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] KANETO,Keiichi: "Transport Mechanisms in evaports CO film evaluated by means of field effect" Jpn.J.Appl.Phys.35. 1802-1805

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ikai,Atsushi: "STM and AFM of biolorganic molecules a structures" Surface Science Reports. 26. 261-332 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mitsui,Keita: "Mechanical Unfolding of α_2-macroglobvlin molecules with AFM" FEBS Letters. 385. 29-33 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takeuchi,Hideo: "Differentiation of Chemically Functional Groups in Stearoyl amide and Anilide with scanning tunneling microscopy" Jan.J.Appl.Phys.35. 3754-3758 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hora,Masahiko: "Crdves nucleation of a seef assembly monolayer on Au(III)studied by Scannins Tunnelins Microscopy" Thin Solid Films. 273. 66-69 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hibino,Masahiro: "Scanning tunneling microscopy study on Dymanic Shuctural fomation in Mired fattyacid monolayers." Thin solid Films. 281. 594-597 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kaneto,Keiichi: "Transported Mechanism in evaporated Cto film evalualed by ment of field effect" Jpn.J.Appl.Phys.35. 1802-1805 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] yoshimura,Arakawa Ikai: "Scanning Tunneling Imaging of Bio-Organic Molecules and their Tunneling Properties" Japanese J. Appl. Phys.34. 3368-3372 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hatta, Nishino Sumi, Hibino: "Ordered Structure Formed by Cholesterol and Biologically Related Molecules by Scanning Tunneling Microscope" Jpn. J. Appl. Phys.34. 3930-3936 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hibino, Sumi, Hatta: "Molecular Arrangement of Fatty Acids Liquid/Graphite Interface Observedby Scanning Tunneling Microscopy" Jpn. J. Appl. Phys.34. 3354-3359 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sigmund,. Bailey, Hara,: "Langmuir-Blodgett Films of 3-Alkylpyrools Studied by Scanning Tunneling Microscopy" hangmuir. 11. 3153-3160 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Iwakabe,Hara: "Anchoring Phase Transition and Bulk Phase Sequence of Liquid Crystals Studied by Scanning Tunneling Microscopy" Mol. Cryst. Hig. Cryst.267. 129-138 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Katsumata,Ide: "Self-Assembly of 2-Thiocytosine Molecules Adsorbed on Au(111)Surface" Jpn. J. Appl. Phys.34. 3360-3362 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshimura,K.,Arakawa,H and Ikai,A: "Scanning Tunneling Imaging of Bio-Organic Molecules" Jpn.J.Appl.Phys.(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Katsumata,S.,and Ide A.: "Scanning Tunneling Microscope Image of Thioguanine Molecules on Au(III)" Jpn.J.Appl.Phys.33. 3723-3725 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Iwakabe,Y.,Kondo.K.,Hara,M.,and Sasabe,H.: "Anchoring Phose of Liquid Crystal Mixture Studied by Scanning Tunneling Microscopy" Langmuir. 10. 3201-3206 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Iwakabe,H.and Hara,M.: "Anchoring Phase Transition and Bulk Phase Sequence of Liquid Crystals studied by Scanning Tunneling Microscopy" Mol.Cryst.Liq.Cryst.(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hibino,Y.,Sumi,A.Hatta,I.: "Atomic Images of Saturated and Unsaturated Fatty Acids at the Liquid Graphite Interface and the Difference of Tunneling Current between them observed bySTM" Jpn.J.Appl.Phys.(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ikai,A.: "Biological nanosystems" Materials Science and Engineering. C1. 59-61 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Imai,K.,Yoshimura,K.,NIshikawa,O.& Ikai,A.: "Scanning Tunneling and Atomic Force Microscopy of T4 Bacteriophage and Tobacco Mosaic Virus" Japanese J.of Applied Physics. 32. 2962-2964 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ikai,A.,Yoshimura,K.,Arisaka,F.& Imai,K.: "Atomic Force Microscopy of Bacteriophage T4 and its Tube-baseplate Complex" FEBS Letters. 326. 39-41 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Umemura,K.,Arakawa,H.,Ikai,A.: "High Resolution Images of Cell Surface Using a Tapping Mode Atomic Force Microscopy" Japanese J.of Applied Physics. 32. L1711-L1714 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ohnisi,S.,Hara,M.,Furuno,T & Sasabe,H.: "Direct Visualization of Polypeptide Shell of Ferritin Molecules by Atomic Force Microscopy" Biophys.J.65. 573-577 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ohnisi,S.,Hara,M.,Furuno,T & Sasabe,H.: "AFM Imaging of Ferritin Molecules Bound to LB Films of Poly-Benzyl-L-Histidine" Mat.Res.Soc.Symp.295. 145 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 猪飼 篤: "STM/AFMによるDNAの構造研究" 日本結晶学会誌. 35. 157-158 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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