| Project/Area Number |
05278113
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Research Institution | Kyoto University |
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Principal Investigator |
IKENAGA Mitsuo Kyoto University, Radiation Biology Center, Professor, 放射線生物研究センター, 教授 (70025378)
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| Co-Investigator(Kenkyū-buntansha) |
NIWA Ohtsura Kyoto University, Radiation Biology Center, Professor, 放射線生物研究センター, 教授 (80093293)
MORIMOTO Kanehisa Osaka University, Faculty of Medicine, Professor, 医学部, 教授 (20143414)
TAKAHASHI Senmtaro Radiation Medical Center, Comparative Environmental Effects Research Group, Group Leader, 比較環境影響研究グループ, 研究室長 (60163268)
YOSHIKAWA Isao Nagasaki University, Faculty of Environmental Studies, Associate Professor, 環境科学部, 助教授 (80039528)
妹尾 久雄 名古屋大学, 環境医学研究所, 教授 (40135380)
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| Project Period (FY) |
1993 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥88,000,000 (Direct Cost: ¥88,000,000)
Fiscal Year 1997: ¥19,000,000 (Direct Cost: ¥19,000,000)
Fiscal Year 1996: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 1995: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 1994: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 1993: ¥17,000,000 (Direct Cost: ¥17,000,000)
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| Keywords | Advanced Living Environment / Human Health Effects / Underground Air Pollution / Oxidative DNA Damage / Space Environment / In Vitro Transformation / Genomic Instability / Magnetic Field / 染色体異常 / 宇宙環境放射線 / 試験管内発癌 / 磁場の遺伝的影響 / 地下生活環境 / 大気中浮遊微粒子 / 骨萎縮 / 宇宙放射線の影響 / 磁場による突然変異 / 大気汚染 |
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| Research Abstract |
The objective of this research group is to study possible health effects of advanced living conditions in the 21th century, such as living in underground cities or in space environment, by using appropriate model systems. The results revealed that : (i)suspended particulated matters in air of Tokyo subway stations contained more Fe and Cr elements than those of above ground, and were more cytotoxic to cultured macrophages, (ii) asbestos induced oxidative DNA damage and polynuclear human cells, (iii) RBE of heavy ions for induction of transformation showed a maximum value (6.3) at LET of 100 keV/μ, (iv) irradiated sperm caused maternal allele mutations in mouse as well as Drosophila, an evidence of radiation-induced genomic instability, and (v) timevarying magnetic Held induced somatic mutations in Drosophila.
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