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DEVELOPMENT OF METAL COMPLEXES WITH PHYSIOLOGICAL RESPONSE FUNCTION

Research Project

Project/Area Number 05303008
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Synthetic chemistry
Research InstitutionNARA WOMEN'S UNIVERSITY

Principal Investigator

YANO Shigenobu  NARA WOMEN'S UNIVERSITY,CHEMISTRY,PROFESSOR, 理学部, 教授 (60011186)

Co-Investigator(Kenkyū-buntansha) FUJII Yuki  IBARAGI UNIVERSITY,CHEMISTRY,PROFESSOR, 理学部, 教授 (50007564)
NAGANO Tetsuo  UNIVERSITY OF TOKYO MEDICINAL CHEMISTRY,ASSOCIATED PROFESSOR, 薬学部, 助教授 (20111552)
SAKURAI Hiromu  KYOTO PHARMACEUTICAL UNIVERSITY,ANALYTICAL CHEMISTRY AND BIOINORGANIC CHEMISTRY,, 薬学部, 教授 (30065916)
OTSUKA Masami  KYOTO UNIVERSITY,CHEMICAL RESEARCH,ASSOCIATED PROFESSOR, 化学研究所, 助教授 (40126008)
OKURA Ichiro  TOKYO INSTITUTE OF TECHNOLOGY,BIOENGINEERING,PROFESSOR, 生命理工学部, 教授 (90089821)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1994: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1993: ¥3,200,000 (Direct Cost: ¥3,200,000)
KeywordsBioactivity / Antifungal Activity / Hybrid Compound / Molecular Recognition / Intercalation / DNA / Active Oxygen / Photodynamic Therapy / 配糖錯体 / 血糖値の制御 / シッフ塩基 / 有機無機複合体 / 生物機能
Research Abstract

Development of metal complexes with physiological response function is highly desirable in various fields. We have carried out the following investigations during this two years. Nickel(II)complex containing N-glycosides derived from D-glucosamine and ethylenediamine showed effective antifungal activity against pathogenic yeast, Candida Albicans. (YANO and KATO)Hydrogen bonding and metal coordination interactions can be used to force aromatic spacers to stack. (AOYAMA)The cell damage by the irradiation of laser light to zinc phthalocyanine incorporated cells were revealed to be caused by singlet oxygen. (OKURA)Artificial ligands were synthesized and it became becapossible to inhibit the activation or the DNA binding of NF-kB and HIV-EP1, kB site binding proteins. (OTSUKA)Self-assembled and higher ordered metal complexes in aqeous solution and in crystal were constructed by intermolecular stacing interactions. (ODANI) Insulin-like effect in terms of blood glucose normalization was inves … More tigated to find anti-diabetic drugs for insulin-dependent diabetes mellitus by vanadium-or selenium-containing complexes. (SAKURAI)Direct electron-transfer reactions of metalloproteins at functional electrodes and their applications have been discussed. (TANIGUCHI)The measurement of DNA-fiber ESR has revealed the binding structure of Cu(II)complexes of amino acids and peptides. (CHIKIRA)High levels of "catalytic stereocontrol based on molecular recognition" have been achieved in the Eu(III)-catalyzed aldol reactions. (NAKAI)Fe(III)TRAA(TPAA : tris(N-(2-pyridylmethy1)-2-aminoethy1)amine)showed high SOD activity not only in vitro but also in vivo. (NAGANO)The administration of Fe(III)-nta solution to rats produces renal cell carcinoma and induces severe tissue damage. (NISHIDA)Monoclonal antiboies to(1R,2R)-cyclohexanediamine platinum(II)-DNA adduct were obtained and characterized by ELISA method. (HIROSE). New cationic Schiff Base complexes were synthesized and the binding constants and modes with calf thymus DNA were investigated. (FUJII)The structures of zinc and mercury complexes including Cys-Pro-Leu-Cys as ligand were studied. (YAMAMURA) Less

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (61 results)

All Other

All Publications (61 results)

  • [Publications] Y.Sugihara: "The Structure of Diethyl(3-pyridyl)borane" J.Chem.Soc.,Chem.Commun.1925-1926 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kobayashi: "The Crystal Structure of a Bisresorcinol Derivative of Anthracene Hydrogen-Bonded Network Formation in Organic Crystals as Effected by Perpendicular and Divergent Hydroxyl Groups" Tetrahedron Lett.34. 7929-7932 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Takeno: "Characterization of Sulfonated Zinc Phthalocyanines as Photosensitizers for Photodynamic Therapy" Lasers in the Life Sciences. 6. 173-179 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Sugiyama: "Transition-Metal Binding Site of Bleomycin.Significance of the β-Aminoalaninamide Appendage in Regulating Oxygen Activation" Heterocycles. 37. 275-282 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Funahashi: "Spectroscopic Evidence for the Redox Reaction between Copper(II)and a Pterin Cofactor Model,6,7-Dimethyl-5,6,7,8-tetrahydropterin" Chem.Lett.385-388 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Goto: "Dependence of Dehydrogenation of Amines towards Coordination Geometry:Oxidation Products of Tricyano[di(2-pyridylmethyl)amine]ferrate(II)from mer and fac Isomers" J.Chem.Soc.,Chem.Commun.2015-2016 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Sakurai: "Unusual generation of hydroxyl radicals in hepatic copper-metallothionein of LEC(Long-Evans Cinnamon)rats in the presence of hydrogen peroxide" Biochem.Biophys.Res.Commun.199. 313-318 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] I.Taniguchi: "Potential-Dependent Rectified Electron Transfer at a Meldola's Blue Incorporated Decanethiol Modified Electrode as a Model of Biological Membrane" Microchem.J.49. 340-354 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Chikira: "Orientations of Copper(II)Complexes of 1,10-Phenanthroline and Its Derivatives on DNA-fibers" Mag.Res.Medicine. 6. 214-215 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Nakai: "[2.3]Wittig Sigmatropic Rearrangement" Organic Reactions. 46. 105-109 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Hayakawa: "Long-Term Administration of L-Arginine Improves Nitric Oxide Release from Kidney in DOCA Salt Hypertensive Rats" Hypertension. 23. 752-756 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Nishida: "Iron Chelates in Biological Systems.Its Relevance to Induction of Pathogenesis of Tissue Damage and Carcinogenesis" Chem.Lett.641-644 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Sato: "Stereospecific Binding of Chemically Modified Salen-type Schiff Base Complexes of Copper(II)with DNA" J.Chem.Soc.,Chem.Commun.625-626 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] J.Hirose: "Characterization of Ascorbate Oxidase from Acremonium sp.HI-25" J.Biochem.115. 811-813 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Yamamura: "Conformation Contorole of Model Peptides by Metal Ions I.Cys-X-Y-Cys and Linear Coordination" Phys.Chem.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Tanase: "Chiral Inversion around the Seven-Coordinated Cobalt Cneter Induced by an Interaction between Sugars and Tetrahedral Oxoanions." Inorg.Chem.33. 5-6 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Sugihara: "The Structure of Diethy(3-pyridy1)borane" J.Chem.Soc., Chem.commun.1925-1926 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kobayashi: "The Crystal Structure of a Bisresorcinol Derivative of Anthracene Hydrogen-Bonded Network Formation in Organic Crystals as Effected by Perpendicular and Divergent Hydroxyl Groups." Tetrahedron Lett.34. 7929-7932 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Takeno: "Characterization of Sulfonated Zinc Phthalocyanine as Photosensitizers for Photodynamic Therapy." Lasers in the Life Sciences. 6. 173-1797 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Sugiyama: "Transition-Metal Binding Site of Bleomycin. Significance of the beta-Aminoalaninamide Appendage in Regulating Oxygen Activation." Heterocycles. 37. 275-282 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Funahashi: "Spectroscopic Evidence for the Redox Reaction between Copper(II)and a Pterin Cofactor Model, 6,7-Dimethy1-5,6,7,8-tetrahydropterin." Chem.Lett.385-388 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Goto: "Dependence of Dehydrogenation of Amines towards Coordination Geometry : Oxidation Products of Tricyano [di(2-pyridylmethyl)amine] ferrate(II)from mer and fac Isomers." J.Chem.Soc.Chem.Commun.2015-2016 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Sakurai: "Unusual generation of hydroxyl radicals in hepatic copper-metallothionein of LEC(Long-Evans Cinnamon)rats in the presence of hydrogen peroxide." Biochem.Biophys.Res.Commun.199. 313-318 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] I.Taniguchi: "Potential-Dependent Rectified Electron Transfer at a Meldola's Blue Incorporated Decanethiol Modified Electrode as a Model of Biological Membrane." Microchem.J.49. 340-354 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Chikira: "Orientations of Copper(II)Complexes of 1,10-Phenanthroline and Its Derivatives on DNA-fibers." Mag.Res.Medicine. 6. 214-215 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Nakai: "[2,3] Witig Sigmatropic Rearrangement." Organic Reactions. 23. 105-109 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Hayakawa: "Long-Term Administration of L-Arginine Improves Nitric Oxide Release from Kidney in DOCA Salt Hypertensive Rats." Hypertension. 23. 752-756 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Nishida: "Iron Chelates in Biological Systems. Its Relevance to Induction of Pathogenesis of Tissue Damage and Carcinogenesis." Chem.Lett.641-644 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Sato: "Stereospecific Binding of Chemically Modified Salen-type Schiff Base Complexes of Copper(II)with DNA." J.Chem.Soc., Chem.Commun.625-626 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] J.Hirose: "Characterization of Ascorbate Oxidase from Acremonium sp.HI-25" J.Biochem.115. 811-813 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Yamamura: "Conformation Contorole of Model Peptides by Metal Ions I.Cys-X-Y-Cys and Linear Coordination." Phys.Chem.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Tanase: "Chiral Inversion around the Seven-Coordinated Cobalt Cneter Induced by an Interaction between Sugars and Tetrahedral Oxoanions." Inorg.Chem.33. 5-6 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Sugihara: "The Structure of Diethyl(3-pyridyl)borane" J.Chem.Soc.,Chem.Commun.1925-1926 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Kobayashi: "The Crystal Structure of a Bisresorcinol Derivative of Anthracene Hydrogen-Bonded Network Formation in Orga ic Crystals as Effected by Perpendicular and Divergent Hydroxyl Groups" Tetrahedron Lett.34. 7929-7932 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Takeno: "Characterization of Sulfonated Zinc Phthalocyaninesas Photosensitizers for Photodynamic Therapy" Lasers in the Life Sciences. 6. 173-179 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Sugiyama: "Transition-Metal Binding Site of Bleomycin.Significance of the β-Aminoalaninamide Appendagein Regulating Oxygen Activation" Heterocycles. 37. 275-282 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Funahashi: "Spectroscopic Evidence for the Redox Reaction between Copper(II)and a Pterin Cofactor Model・・・・" Chem.Lett.385-388 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.Goto: "Dependence of Dehydrogenation of Amines towards Coordination Geometry:Oxidation Products of Tricyano〔di(2-pyridylmethyl)amine〕ferrate(II)from mer and fac Isomers" J.Chem.Soc.,Chem.Commun.2015-2016 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Sakurai: "Unusual generation of hydroxyl radicals in hepatic copper-metallothionein of LEC(Long-Evans Cinnamon)rats in the presence of hydrogen peroxide" Biochem.Biophys.Res.Commun.199. 313-318 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] I.Taniguchi: "Potential-Dependent Rectified Electron Transfer at a Meldola's Blue Incorporated Decanethiol Modified Electrodeas a Model of Biological Membrane" Microchem.J.49. 340-354 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.Chikira: "Orientations of Copper(II)Complexes of 1,10-Phenanthroline and Its Derivatives on DNA-fibers" Mag.Res.Medicine. 6. 214-215 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Nakai: "[2.3]Wittig Sigmatropic Rearrangement" Organic Reactions. 46. 105-109 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Hayakawa: "Long-Tem Administration of L-Arginine Improves Nitric Oxide Release from Kidney in DOCA Salt Hypertensive Rats" Hypertension. 23. 752-756 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Nishida: "Iron Chelates in Biological Systems.Its Relevance to Induction of Pathogenesis of Tissue Damage and Carcinogenesis" Chem.Lett.641-644 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Sato: "Stereospecific Binding of Chemically Modified Salen-type Schiff Base Complexes of Copper(II)with DNA" J.Chem.Soc.,Chem.Commun.625-626 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] J.Hirose: "Characterization of Ascorbate Oxidase from Acremoniumsp. HI-25" J.Biochem.115. 811-813 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Yamamura: "Confomation Control of Model Peptides by Metal Ions I.Cys-X-Y-Cys and Linear Coordination" Phys.Chem.

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Tanase: "Chiral Inversion around the Seven-Coordinated Cobalt Cneter Induced by an Interaction between Sugars and Tetrahedral Oxoanions." Inorg.Dhem.33. 5-6 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 矢野 重信: "Inversion of Configuration around the Seven-Coordinated Cobalt Center Induced by an Interaction between Sugars and Tetrahedral Oxoanions" Inorg.Chem.33. 5-6 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 大倉 一郎: "Oxidation of halogenated propanes with Methylosinus trichosporium(OB3b)" J.Mol.Catal.83. L5-L10 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 大塚 雅巳: "Cleavage of Yeast tRNA^<Phe> with Ni(III)and Co(III)Complex of Bleomycin" Biochem.Biophys.Res.Commun.191. 1338-1346 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小谷 明: "Ternary Metal(II)Complexes with Tyrosine-Containing Dipeptides.Structures of Copper(II)and Palladium(II)Complexes Involving L-Tyrosylglycine and Stabilization of Copper(II)Complexes Due…" Inorg.Chem.32. 4951-4959 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 北島 信正: "A Reaction Mimic of Tyrosine Hydroxylase:Hydroxylation of a Phenoxo Ferric Complex to a Catecholato Complex with mCP13A" J.Am.Chem.Soc.115. 9335-9336 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 黒田 玲子: "Chiral Nsubstituted Porphyrins helated to Heme Inactivation Products.First Crystallographic Determination of Absolute Stereochemistry and Correlation with Circular Dichroism" J.Am.Chem.Soc.115. 1169-1170 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 桜井 弘: "New orally active insulin-mimetic vanadyl complex:Bis(pyrrolidine-N-carbodithioato)oxovanadium(IV)" J.Med.Chem.(in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] 千喜良 誠: "Stereospecific Binding of Chemically Modified Salen-type Schiff Base Complexes of Copper(II)with DNA" J.Chem.Soc.,Chem.Commun.(in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] 中井 武: "Enantio and Diastereoselective Catalysis of Addition Reaction of Allylic Silanes and Stannanes to Glyoxylates by Binaphthol-derived Titanium Complex" Tetrahedron. 49. 1783-1792 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 長野 哲雄: "RealTime Measurement of Nitric Oxide Produced Ex Vivo by Luminol-H_2O_2 Chemiluminescence Method" J.Biol.Chem.268. 23106-23110 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 西田 雄三: "High catalytic activity of trans-FeCl_2(cyclam)^+ for peroxidation of linolenic acid" Chem.Lett.411-414 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 廣瀬 順造: "Cytotoxicity of Platinum(IV)and Platinum(II)Complexes Containing 1R,2R-Cyclohexanediamine as a Ligand" Biol.Pharm.Bull.16. 1014-1018 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山村 剛士: "A Square Planar NiS_4 Unit with an Aliphatic Thiolato-Thiolato Thioether Donor Set: A Carbon Monoxide Dehydrogenase Model that Binds CO" J.Chem.Soc.,Chem.Commun.1656-1658 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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