| Project/Area Number |
05304026
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
TODA Noboru Shiga Univ.Med.Sci., Pharmacol.Prof., 医学部, 教授 (50025590)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAYANAGI Issei Toho Univ. Pharm. Sch.Pharmacol., Prof., 薬学部, 教授 (70012599)
ABIKO Yasushi Asahikawa Med.College Pharmacol., Prof., 医学部, 教授 (90041821)
SAITO Hideya Hokkaido Univ.Med.Sch.Pharmacol., Prof., 医学部, 教授 (20000929)
SASA Masashi Hiroshima Univ.Med.Sch.Pharmacol., Prof., 医学部, 教授 (20025654)
KURIYAMA Kinya Kyoto Prefec.Univ. Med., Pharmacol., Prof., 医学部, 教授 (20079734)
加藤 隆一 慶応義塾大学, 医学部, 教授 (40112685)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥18,400,000 (Direct Cost: ¥18,400,000)
Fiscal Year 1995: ¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1994: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 1993: ¥6,800,000 (Direct Cost: ¥6,800,000)
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| Keywords | Drug Receptor / GABA receptor / Nitric Oxide / Endothelin / Tachykinin / Ethanol / Serotonin / Nicotine / Dopamine |
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| Research Abstract |
This research group was organized by the aim of (1) analyzing mechanisms of action of new neurotransmitters on receptors and regulations of receptor function in the brain and peripheral organs and tissues by the use of advanced experimental technique and (2) introducing new concepts of interaction between agonists, receptors, signal-transduction processes and cellular responses.
The members of this group carried out their study with the brain, heart, blood vessel, extravascular smooth muscle and cultured cells in vitro and in vivo in various animal species, including rhdents, dogs and monkeys. we discussed with great interests on (1) problems of contrasting of different signal transduction and cellular responses mediated by the same receptor subtypes in the brain and peripheral tissues, (2) physiological roles and pathophysiological implications of recently-determined new nerves in which NO acts as neurotransmitter, (3) some of the so-called selective antagonists of receptor subtypes that are effective only in certain animals species, (4) new mechanisms of agonist action through classic receptor activation that are proposed from findings obtained by advanced technique of analysis, and (5) newly-found receptor-G-protein-second messenger systems. I believe that through the discussion, exchange of ideas and presentation of new findings in this group activity, each of the members greatly contributed to the progress of receptor research and in addition obtained valuable fruits from presentations by others for the future study and broadened the knowledge of receptor characteristics.
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