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Assessment of exposure to solvent mixture by biological monitoring

Research Project

Project/Area Number 05304030
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

IKEDA Masayuki  Kyoto University, Fac.of.Med.Professor, 医学部, 教授 (00025579)

Co-Investigator(Kenkyū-buntansha) 河合 俊夫  中央労働災害防止協会大阪センター, 主任研究員
緒方 正名  川崎医療福祉大学, 医療福祉学部, 教授 (70032844)
佐藤 章夫  山梨医科大学, 医学部, 教授 (40020747)
竹内 康弘  名古屋大学, 医学部, 教授 (90022805)
井口 弘  京都大学, 医学部, 助手 (90025643)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1994: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥4,800,000 (Direct Cost: ¥4,800,000)
KeywordsAnalysis of biological specimen / Biological monitoring / Exposure evaluation / Solvent mixture / Occupational Health / トルエン / 生体影響 / メチルエチルケトン / イソプロピルアルコール / ヘキサン
Research Abstract

Ikeda reviewed existing reports on combined exposure to solvents and concluded that no metabolic interaction between the solvents is likely to occure when the exposured are below current occupational exposure limits.Such conclusion was confirmed when industrial workers were biologically monitored after combined exposure to stirene and acetone, toluene and xylene, toluene and MEK,or toulene and IPA(Ikeda, Iguchi, Kawai).Takeuchi observed toluenne-induced suppression of hexane metabolism in rats as well as in factory workers.Sato employed rats in which solvent metabolism was induced by repeated oral administration of ethanol, and confirmed both in vitro and in vivo that the metabolism of trichloroethylene and chloroform was modified by the induction only when the exposure was high whereas metabolism of methylchloroform was affected by the induction regardless of exposure intensity.Ogata made evaluation of biological monitoring in comparison with traditional environmental monitoring, and proposed a version of the additiveness formula applicable to biological monitoring of combined exposure to solvents.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (47 results)

All Other

All Publications (47 results)

  • [Publications] Mizunuma K et al.: "Exposure-excretion relationship of styrene and acetone in factory workers:A comparison of a lipophilic solvent and a hydrophilic solvent" Arch Environ Contam Toxicol. 25. 129-133 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kawai T et al.: "Comparative evaluation of blood and urine analysis as a tool for biological monitoring of n-hexane and toluene" Int Arch Occup Environ Health. 65. S123-S126 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Huang M-Y et al.: "Exposure of workers to a mixture of toluene and xylenes.I.Metabolism." Occup Environ Med. 51. 42-46 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Chen Z et al.: "Exposure of workers to a mixture of toluene and xylenes.I.Effects." Occup Environ Med. 51. 47-49 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ikeda M: "Complex exposures:Potentials for assessing integrated exposures." Clin Chem. 40. 1444-1447 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ukai H et al.: "Occupational exposure to solvent mixtures;effects on health and metabolism." Occup Environ Med. 51. 523-529 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ichihara G et al.: "Combined effects of hexane and methyl ethyl ketone on the peripheral nerve of the rats." Proc Int Conf Periph Nerve Tox. 123-125 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takeuchi Y et al.: "Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene." Int Arch Occup Environ Health. 65. S227-S230 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kamijima M et al.: "Metabolic acidosis and renal tubular injury due to pure toluene inhalation." Arch Environ Health. 49. 410-413 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fukaya Y et al.: "Determination of 3,4-dimethylhippuric acid as a biological monitoring index for trimethylbenzene exposure in transfer printing workers." Int Arch Occup Environ Health. 65. 295-297 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shibata E et al.: "Digital nerve conduction velocities of workers exposed to hexane and toluene." Proc 6th Int Conf Comb Eff Environ Fact. 241-244 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kaneko T et al.: "Enzymes induced by ethanol differently affect the pharmacokinetics of trichloroethylene and 1,1,1-trichloroethane." Occup Environ Med. 51. 113-119 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Wang P-Y et al.: "Dose-and route-dependency of metabolism and toxicity of chloroform in ethanol-treated rats." Arch Toxicol. 69. 18-23 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 緒方正名、田口豊郁、: "生物学的モニタリング-時に単一、複合化学物質曝露の評価法" 川崎医療福祉学会誌. 3. 11-21 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ogata M et al.: "Biological monitoring VII:Occupational exosures to mixtures of industrial chemicals." Appl Occup Environ Hyg. 8. 609-617 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 緒方正名: "混合有機溶剤曝露の溶剤代謝産物、尿中溶剤より暴露の評価法" 医学と生物学. 129. 303-308 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mizunuma, K et al.: "Exposure-excretion relationship of stirene and acetone in factory workers : A comparison of a lipophilic solvent and a hydrophilic solvent" Arch Environ Contam Toxicol. 25. 129-133 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kawai, T et al.: "Comparative evaluation of blood and urine analysis as a tool for biological monitoring of n-hexane and toluene" Int Arch Occup Environ Health. 65. S123-S126 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Huang M-Y et al.: "Exposure of workers to a mixture of toluene and xylenes.I.Metabolism." Occup Environ Med. 51. 42-46 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Chen Z et al.: "Exposure of workers to a mixture of toluene and xylenes.I.Effects." Occup Environ Med. 51. 47-49 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ikeda, M.: "Complex exposures : Potentials for assessing integrated exposures." Clin Chem. 40. 1444-1447 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ukai, H.et al.: "Occupational exposure to solvent mixtures ; effects on health and metabolism." Occup Environ Med. 51. 523-529 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ichihara, G.et al.: "Combined effects of hexane and methyl ethyl ketone on the peripheral nerve of the rats." Proc Int Conf Periph Nerve Tox. 123-125 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takeuchi, Y.et al.: "Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene." Int Arch Occup Environ Health. 65. S227-S230 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kamijima, M.et al.: "Metabolic acidosis and renal tubular injury due to pure toluene inhalation." Arch Environ Health. 49. 410-413 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fukaya, Y.et al.: "Determination of 3,4-dimethylhippuric acid as a biological monitoring index for trimethylbenzene exposure in transfer printing workers." Int Arch Occup Environ Health. 65. 295-297 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shibata, E.et al.: "Digital nerve conduction velocities of workers exposed to hexane and toluene." Proc 6th Int Conf Comb Eff Environ Fact. 241-244 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kaneko, T.et al.: "Enzymes induced by ethanol differently affect the pharmacokinetics of trichloroethylene and 1,1,1-trichloroethane." Occup Environ Med. 51. 113-119 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Wang P-Y et al.: "Dose-and route-dependency of metabolism and toxicity of chloroform in ethanol-treated rats." Arch Toxicol. 69. 18-23 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ogata, M.et al.: "Biological monitoring VII : Occupational Exposures to mixture of industrial chemicals." Appl Occup Environ Health. 8. 609-617 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mizunuma K et al.: "Exposure-excretion relationship of styrene and acetone in factoty workers: A comparison of a lipophilic solvent and a hydrophilic solvent" Arch Environ Contam Toxicol. 25. 129-133 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kawai T et al.: "Comparative evaluation of blood and urine analysis as a tool for biological monitoring of n__--hexane and toluene" Int Arch Occup Environ Health. 65. S123-S126 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Huang M-Y et al.: "Exposure of workers to a mixture of toluene and xylenes.I.Metabolism." Occup Environ Med. 51. 42-46 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Chen Z et al.: "Exposure of workers to a mixture of toluene and xylenes.I.Effects." Occup Environ Med. 51. 47-49 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ikeda M: "Complex exposures:Potentials for assessing integrated exposures." Clin Chem. 40. 1444-1447 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ukai H et al.: "Occupational exposure to solvent mixtures;effects on health and metabolism." Occup Environ Med. 51. 523-529 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ichihara G et al.: "Combined effects of hexane and methyl ethyl ketone on the peripheral nerve of the rats." Proc Int Conf Periph Nerve Tox. 123-125 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takeuchi Y et al.: "Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene." Int Arch Occup Environ Health. 65. S227-S230 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kamijima M et al.: "Metabolic acidosis and renal tubular injury due to pure toluene inhalation." Arch Environ Health. 49. 410-413 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Fukaya Y et al.: "Determination of 3,4-dimethylhippuric acid as a biological monitoring index for trimethylbenzene exposure in transfer printing workers." Int Arch Occup Environ Health. 65. 295-297 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shibata E et al.: "Digital nerve conduction velocities of workers exposed to hexane and toluene." Proc 6th Int Conf Comb Eff Environ Fact. 241-244 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kaneko T et al.: "Enzymes induced by ethanol differently affect the pharmacokinetics of trichloroethylene and 1,1,1-trichloroethane." Occup Environ Med. 51. 113-119 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Wang P-Y et al.: "Dose- and route-dependency of metabolism and toxicity of chloroform in ethanol-treated rats." Arch Toxicol. 69. 18-23 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 緒方正名、田口豊郁、: "生物学的モニタリング-時に単一、複合化学物質曝露の評価法" 川崎医療福祉学会誌. 3. 11-21 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ogata M et al.: "Biological monitoring VII:Occupational exosures to mixtures of industrial chemicals." Appl Occup Environ Hyg. 8. 609-617 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 緒方正方: "混合有機溶剤曝露の溶剤代謝産物、尿中溶剤より曝露の評価法" 医学と生物学. 129. 303-308 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] I.Ikeda et al.: "Effects on health and metabolism after occupational exposure to solvent mixtures" Occup.Environ.Med.(発表予定).

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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