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Studies on Safety and Effectiveness of Dentin Pretreatment Agents, Pulp Capping Agents and Base Materials

Research Project

Project/Area Number 05304043
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionHokkaido University

Principal Investigator

SHIMOKOBE Hirokata  Hokkaido Univ., Sch.of Dent., Professor, 歯学部, 教授 (20014011)

Co-Investigator(Kenkyū-buntansha) SHINTANI Hideaki  Hiroshima Univ., Sch.of Dent., Professor, 歯学部, 教授 (80034239)
FUJII Benji  Osaka Dental Univ., Sch.of Dent., Professor, 歯学部, 教授 (00066979)
AONO Masao  Asahi Univ., Sch.of Dent., Professor, 歯学部, 教授 (70037498)
KOHNO Atsushi  Tsurumi Univ., Sch.of Dent., Professor, 歯学部, 教授 (00064345)
IWAKU Masaaki  Niigata Univ., Sch.of Dent., Professor, 歯学部, 教授 (70013927)
永澤 恒  九州大学, 歯学部, 教授 (10013848)
原 学郎  愛知学院大学, 歯学部, 教授 (80064773)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥23,300,000 (Direct Cost: ¥23,300,000)
Fiscal Year 1994: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1993: ¥17,700,000 (Direct Cost: ¥17,700,000)
KeywordsDentin Pretreatment Material / Antibacterial Capping Agent / Base Cement / Dentin Primer / Phytic Acid / EDTA LaNa / Tannic Acid / Cytotoxity / 抗菌性覆髄剤 / ベース材
Research Abstract

1.A new cytotoxic test of dental materials on human neutrophils was established by determining the production of O_2^- and the release of LDH.The addition of collagen-combined BMP induces differentiation of bone marrow stromal cells into osteoblasts.(shimokobe, Matsui and Inoue)
2.The antibacterial capping agent(alpha-TCP with mixed antibacterial drugs)effectively disinfected bacterially contaminated pulp tissue without destroying surrounding pulp tissue(Iwaku).
3.The dentin priming by the aqueous solution of the ethylene glycol or 1,6-hexanediol was considered to be desirable because the contraction gap formation of the light activated resin compostite was prevented. And the possible side effect on the skin tissue by the methacrylate derivatives was avoided by using the diol solutions.(Hisamitsu)
4.When the dentin surface was treated with chelating agent(phytic acid)and metallic ion(Sn^<2+>), shear bond strength of resin to dentin did not change after 1,000 thermo-cycled(Kohno and Sakamo … More to).
5.Glass ionomer lining materials showed the strongest cellular growth of ten pulp capping materials tested which did not show any mutagenic potential using UMU-test kit(Aono).
6.The dentin surface treated with La-containing conditioner showed higher hardness, better acid resistance and higher bond strength with resin bonding agent(Hara and Senda).
7.Among three experimental penetrometers of Al, Cu or Ti for objective measuring of radiopacity of base cements, Ti-penetrometer revealed the best results(Fujii and Narikawa).
8.Increased concentration of tannic acid and increased incubation times in the acid effectively decreased the dissolved amount of dentin collagen(Shintani).
9.Not only calcium hydroxide but also alkyl salicylates influenced the antimicrobial activity of the set calcium hydroxide cements(Nagasawa).
10.The grinding of tetracalcium phosphate(TTCP)increased the mcchanical strength of the cement based on polymethyl vinyl ether-maleic acid and TTCP,decreased its solubility, and accelerated the hydroxyapatite formation(Matsuya). Less

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (53 results)

All Other

All Publications (53 results)

  • [Publications] 藤江克俊: "ボンディング材がヒト白血球の細胞機能に与える影響" 日本歯科保存学会雑誌. 37. 1279-1293 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yayoi Hashimoto: "Effect of BMP on the Differentiation of Bone Marrow Stromal Cells into Osteoblasts in a Collagen-Gel Culture." 歯科基礎医学会雑誌(印刷中). 37. (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 鮎川幸雄: "生体親和性直接覆髄剤に対するヒト歯髄の反応" 日本歯科保存学会雑誌. 36. 1146-1159 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 鮎川幸雄: "生体親和性抗菌性直接覆髄剤に対するヒト歯髄の反応-混合抗菌剤の改良について-" 日本歯科保存学会雑誌. 37. 643-651 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kunihiro Yoshiba: "Histological observations of hard tissue barrier formation in amputated dental pulp capped with α-tricalcium phosphate containing calcium hydroxide." Endodontics & Dental Traumatology22GD05:10. 113-120 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kunihiro Yoshiba: "Effects of Antibacterial Capping Agents on Dental Pulps of Monkeys Mechanically Exposed to Oral Microflora." Journal of Endodontics. 21(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hisashi Chigira: "Self-etching Dentin Primers Containing Phenyl-P." Journal of Dental Research. 73. 1088-1095 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Chihiro Tani: "Effect of Filler Content on Bonding Efficacy of 4-META MMA/TBB Bonding Agent." Dental Materials Journal. 13. 131-137 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kuniyuki Yokoi: "Water Content in Experimental Dentine Primers to Minimize the Contraction Gap Width of a Light-cured Resin Composite." Journal of Dentistry. 23(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Chihito Tani: "Efficacy of Dentin Bonding Agents Combined with Self-etching Dentin Primers Containing Phenyl-P." Dental Materials Journal. 12. 219-224 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Manabe Atsufumi: "Effect of Delayed Light Curing of a Resin Composite on Marginal Integrity in Cylindrical Dentine Cavities." Journal of Dentistry. 21. 344-349 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kazuyuki Katsuno: "A Delayed Hypersensitivity Reaction to Dentin Primer in the Guinea Pig." Journal of Dentistry. 23(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 薄井秀樹: "キレート化剤と金属イオンを組み合わせたプライマーの各種ボンディング剤への応用" 日本歯科保存学雑誌. 36. 1031-1053 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kanamori K.: "Effect of Dentin Pretreatment with EDTA-La-Na on Resin-Dentin Bonding" Aichi-Gakuin Dental Science. 6. 17-23 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 金森吉五郎: "EDTA LaNaによるレジン接着のための象牙質前処理に関する研究21GC15:愛知学院大学歯学会誌" 32. 123-137 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松井 治: "象牙質前処理が根管象牙質の硬さに及ぼす影響" 愛知学院大学歯学会誌. 32. 139-157 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 水野和子: "デンタルX線写真の濃度補正のための歯科用ペネトロメータの試作" 日本歯科保存学雑誌. 36. 1668-1672 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takahashi H.: "A Pilot Study of Exposure of the Smear Layer to Tannic Acid Solutions" Journal of Prosthetic Dentistry. 70. 261-263 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoko Matsuya: "Effect of abietic acid and poly(methyl methacrylate) on the dissolution process of zinc oxide-eugenol cement" Biomaterials. 15. 307-314 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Fujie: "The Effect of Bonding Agest on Cellular Function of Iluman Leckocyte." Japan J Conserv Dent. 37. 1279-1293 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Hashimoto, et al: "Effect of BMP on the Differentiation of Bone Marrow Stromal Cells into Osteblasts in a Collagen-Gel Culture." Jpn J Oral Biol. 37(in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Ayukawa: "Pulpal Response of Human Teeth to Biocompatible Pulp-capping Agent" Japan J Consery Dent. 36. 1146-1159 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Ayukawa: "Pulpal Response of Human teeth to Antibacterial Pulp-capping Agent.-Improvement of Mixed Drugs-" Japan J Conserv Dent. 37. 643-651 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Yoshiba, et al: "Histological observations of hard tissue barrier formationin amputated dental pulp capped with alpha-tricalcium phosphate contaning calcium hydroxide" Endodontics & Dental Traumatology. 10. 113-120 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Yoshiba, et al: "Effects of Antibacterial Capping Agents on Dental Pulps of Monkeys Mechanically Exposed to Oral Microflora" Journal of Endodontics. 21(in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Chigira, et al: "Self-etcing Dentin Primers Contaning Phenyl-P" J Dent Res. 73. 1088-1095 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] C.Tani, et al: "Effect of Filler Content on Bonding Efficacy of 4-META MMA/TBB Bonding Agent" Dent Mater J. 13. 131-137 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Yokoi: "Water Content in Experimental Dentine Primers to Minimize the Contraction Gap Width of a Light-cured Resin Composite" Journal of Dentistry. 23(in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] C.Tani, et al: "Efficacy of Dentin Bonding Agents Combined with Self-etching Dentin Primers Containing Phenyl-P" Dent Mater J. 12. 219-224 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.Manabe: "Effect of Delayd Light Curing of a Resin Composite on Marginal Integrity in Cylindrical Dentine Cavities" Journal of Dentistry. 21. 344-349 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Katsuno: "A Delayd Hypersensitivity Reaction to Dentin Primer in the Guinea Pig" Journal of Dentistry. 23(in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Usui: "Application of Primers Combined Chelating Agent with Metallic Ion to Various Bonding Agent" Japan J Conserv Dent. 36. 1031-1053 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kanamori, et al: "Effect of Dentin Pretreatment with EDTA-La-Na on Resin-Dentin Bonding" Aichi-Gakuin Dent Sci. 6. 17-23 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kanamori: "Effect of Dentin Pretreament for Resin-Bonding with EDTA LaNa" Aichi-Gakuin J Dent Sci. 32. 123-137 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] O.Matsui: "Effects Dentin Conditionings on the Hardness of Root Canal Dentin" Aichi-Gakuin J Dent Sci. 32. 139-157 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Mizuno, et al: "Development of Dental Penetrometers for Objective Measuring of Density of Dental X-ray Films" Japan J Conserv Dent. 36. 1668-1672 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Takahashi, et al: "A Pilot Study of Exposure of the Smear Layr to Tannic Acid Solutions" J Prosthet Dent. 70. 261-263 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Matsuya, et al: "Effect of abietic acid and poly(methyl methacrylate) on the dissolution process of zinc oxide-eugenol cement" Biomaterials. 15. 307-314 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 藤江克俊: "ボンディング材がヒト白血球の細胞機能に与える影響" 日本歯科保存学会雑誌. 37. 1279-1293 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yayoi Hashimoto: "Effect of BMP on the Differentiation of Bone Marrow Stromal Cells into Osteoblasts in a Collagen-Gel Culture." 歯科基礎医学会雑誌. 37(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 鮎川幸雄: "生体親和性抗菌性直接覆髄剤に対するヒト歯髄の反応-混合抗菌剤の改良について-" 日本歯科保存学会雑誌. 37. 643-651 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kunihiro Yochiba: "Histological observations of hard tissue barrier formation in amputated dental pulp capped with α-tricalcium phosphate containing calcium hydroxide." Endodontics & Dental Traumatology. 10. 113-120 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kunihiro Yoshiba: "Effects of Antibacterial Capping Agents on Dental Pulps of Monkeys Mechanically Exposed to Oral Microflora." Journal of Endodontics. 21(in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hisashi Chigira: "Self-etching Dentin Primers Containing Phenyl-P." Journal of Dental Research. 73. 1088-1095 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Chihiro Tani: "Effect of Filler Content on Bonding Efficacy of 4-META MMA/TBB Bonding Agent." Dental Materials Journal. 13. 131-137 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kuniyuki Yokoi: "Water Content in Experimental Dentine Primers to Minimize the Contraction Gap Width of a Light-cured Resin Composite." Journal of Dentistry. 23(in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kazuyuki Katsuno: "A Delayed Hypersensitivity Reaction to Dentine Dentin Primer in the Guinea Pig." Journal of Dentistry. 23(in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoko Matsuya: "Effect of abietic acid and poly(methyl methacrylate)on the dissolution process of zinc oxide-eughenol cement" Biomaterials. 15. 307-314 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 鮎川幸雄: "生体親和性抗菌性直接覆髄剤に対するヒト歯髄の反応" 日本歯科保存学会雑誌. 37(予定). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hitoshi Takahashi: "A pilot study of exposure of the smear layer to tannic acid solution" Journal of Prosthetic Dentistry. 70. 261-263 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 金森吉五郎: "EDTALaNaによるレジン接着のための象牙質前処理に関する研究" 愛知学院大学歯学会誌. 32. 125-139 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 水野和子: "デンタルX線写真の濃度補正のための歯科用ペネトロメーターの試作" 日本歯科保存学会雑誌. 36. 1668-1672 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoko Matsuya: "Effect of abietic acid and poly(methyl methacrylate)on the dissolution process of zinc oxide-eugenol cement" Biomaterials. (予定). (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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